Does Patient-Specific Instrumentation Have a Higher Rate of Early Osteolysis Than Standard Referencing Techniques in Total Ankle Arthroplasty? A Radiographic Analysis
Abstract:Introduction: Patient-specific instrumentation (PSI) has been developed for total ankle arthroplasty (TAA), with proven benefits. One concern regarding PSI is the need for more soft tissue dissection in order to accurately position the PSI guides, which has the theoretical disadvantage of increased osteolysis. The purpose of our study is to compare the incidence and magnitude of osteolysis for the INFINITY Total Ankle System between PSI and standard referencing (SR) techniques. Methods: Sixty-seven patients wh… Show more
“…This is of concern because it may carry the risk of impaired bony ingrowth of the implants. Escudero et al found a slightly higher, though not significant, risk of osteolysis in the PSI group compared with SR. 10 This agrees with our findings, wherein a trend for a higher risk for radiolucent lines was observed in the PSI group (2 vs 1 case in the SR group). However, the numbers in the current study are too low to conclude whether the increased intraoperative damage to the periarticular bone affects the incorporation of the implants in TAA, and more research is needed before a conclusion can be drawn.…”
Background: Existing literature on the superiority of patient-specific instrumentation (PSI) in total ankle arthroplasty (TAA) over standard referencing (SR) is limited. Advantages presented include better implant alignment, shorter operating times, and increased accuracy of implant size prediction. The aim of this retrospective study was to analyze PSI in the hands of an experienced foot and ankle surgeon new to both PSI and SR for this specific implant, in regard to determining implant alignment, operative times, and radiologic short-term outcome and predicting implant size for tibial and talar components. Methods: Twenty-four patients undergoing TAA using PSI were compared to 25 patients using SR instrumentation. Outcome measures included alignment of the tibial component (α coronal plane, γ sagittal plane), the tibiotalar tilt (β), and the talar offset x on the sagittal view as well as the presence of radiolucent lines, operation time, and wound healing. Postoperative outcome was assessed at 6 weeks, 4 months, and 1 year postoperatively. Results: Implant positioning was similar in both groups, and no advantage in regard to the operative time could be seen when comparing TAA using PSI to SR. Implant size prediction was more reliable for the tibia than for the talus. Three patients (1 from the SR group and 2 from the PSI group) showed radiolucent lines around the tibial component. Two patients (both SR group) suffered delayed wound healing, albeit not requiring any additional measures. Conclusion: The PSI method did not show an advantage over SR in regard to positioning of the components or the duration of the surgery. The current study suggests that no initial advantage of PSI over SR are to be expected in standard total ankle replacement. Level of Evidence: Level III, retrospective study.
“…This is of concern because it may carry the risk of impaired bony ingrowth of the implants. Escudero et al found a slightly higher, though not significant, risk of osteolysis in the PSI group compared with SR. 10 This agrees with our findings, wherein a trend for a higher risk for radiolucent lines was observed in the PSI group (2 vs 1 case in the SR group). However, the numbers in the current study are too low to conclude whether the increased intraoperative damage to the periarticular bone affects the incorporation of the implants in TAA, and more research is needed before a conclusion can be drawn.…”
Background: Existing literature on the superiority of patient-specific instrumentation (PSI) in total ankle arthroplasty (TAA) over standard referencing (SR) is limited. Advantages presented include better implant alignment, shorter operating times, and increased accuracy of implant size prediction. The aim of this retrospective study was to analyze PSI in the hands of an experienced foot and ankle surgeon new to both PSI and SR for this specific implant, in regard to determining implant alignment, operative times, and radiologic short-term outcome and predicting implant size for tibial and talar components. Methods: Twenty-four patients undergoing TAA using PSI were compared to 25 patients using SR instrumentation. Outcome measures included alignment of the tibial component (α coronal plane, γ sagittal plane), the tibiotalar tilt (β), and the talar offset x on the sagittal view as well as the presence of radiolucent lines, operation time, and wound healing. Postoperative outcome was assessed at 6 weeks, 4 months, and 1 year postoperatively. Results: Implant positioning was similar in both groups, and no advantage in regard to the operative time could be seen when comparing TAA using PSI to SR. Implant size prediction was more reliable for the tibia than for the talus. Three patients (1 from the SR group and 2 from the PSI group) showed radiolucent lines around the tibial component. Two patients (both SR group) suffered delayed wound healing, albeit not requiring any additional measures. Conclusion: The PSI method did not show an advantage over SR in regard to positioning of the components or the duration of the surgery. The current study suggests that no initial advantage of PSI over SR are to be expected in standard total ankle replacement. Level of Evidence: Level III, retrospective study.
Background: The Integra Cadence total ankle replacement (TAR) is a fourth-generation anatomic, fixed-bearing implant requiring minimal tibial and talar resection, which has been in clinical use since June 2016. The primary purpose of this study is to assess its short-term clinical and radiographic outcomes after TAR using this prosthesis. Methods: This is a prospective case series of consecutive patients that underwent TAR using this novel fourth-generation prosthesis between June 2016 and November 2017. The primary outcome of interest was the Ankle Osteoarthritis Scale (AOS). Secondary outcomes included Short Form Health Survey–36 (SF-36) scores, radiographic alignment, complications, reoperations, and revisions. Results: In total, 69 patients were included in our study. Fifty-one patients (73.9%) required a total of 91 ancillary procedures. Postoperatively, AOS pain scores decreased significantly by an average of 17.8±30.1 points from 45.9±18.2 to 28.4±27.3 ( P < .001). AOS disability scores also decreased significantly following surgery by an average of 22.0±30.5 points from 53.9±18.5 to 32.5±27.9 ( P < .001). The SF-36 physical component summary score improved 10.4±9.8 points from 33.1±9.1 to 42.6±9.1 ( P < .001). Radiographic analysis demonstrated significant improvement to neutral coronal plane alignment, which was achieved in 97% of patients ( P < .01) with no cyst formation at 2 years. There was 1 reported complication, 9 reoperations, and no metal or polyethylene component revisions. Overall, the 2-year implant survivorship was 100% in our cohort. Eighteen patients (26.1%) demonstrated fibrous ingrowth of the tibial component. However, outcome scores for these patients did not demonstrate any negative effects. Conclusions: In our hands, this TAR system demonstrated excellent early clinical and radiographic outcomes. Patients reported improved physical health status, pain, and disability in the postoperative period. Total ankle instrumentation allowed for accurate and reproducible implantation with correction of coronal and sagittal plane deformities. Early results for the clinical use of this TAR system are promising, but further long-term prospective outcome studies are necessary. Level of Evidence: Level IV, case series.
“…All 14 were examined for inclusion and exclusion, which resulted in 6 total published studies with clinical outcomes (Figure 1). 11,[14][15][16][17][18] All were retrospective. Four were level IV and 2 were level III studies.…”
Ankle arthroplasty is a viable treatment option for end-stage ankle arthritis and has shown improvements in pain relief, motion, as well as function and gait. Newer generation total ankle prostheses have improved instrumentation and surgical techniques, as well as minimal bone resection on both the tibia and talus. The purpose of this systematic review was to determine the short-term clinical success of the INFINITY total ankle, including the common complications and rate of revision with this prosthesis. We performed a systematic review of electronic databases that included reported complications and revisions using this prosthesis. Complications were recorded according to the Glazebrook classification. Six total published studies with clinical outcomes and complications and 432 prostheses were included. The weighted mean follow-up was 24.5 months and weighted mean patient age was 62.3 years. There were 43 (10.0%) total complications—9 low grade, 16 medium grade, and 18 high grade. There were 26 total revision procedures (6.0%). Revisions were mostly performed for deep infection, aseptic loosening, and subsidence. When including deep infections, the overall implant survivorship was 94%. When excluding the 8 deep infections requiring revision, implant survivorship was 96%. The INFINITY has acceptable short-term complication and revision rates. This fourth-generation prosthesis compares to prior reported studies with earlier generation ankle implants in the short term. Level of Evidence: IV
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