Does Participation in Psychosocial Treatment Augment the Benefit of Clozapine?

Abstract

Background: This study examines the role of participation in psychosocial treatment as a mediator of the clinical effectiveness of clozapine.

Effectiveness and Cost of Olanzapine and Haloperidol in the Treatment of Schizophrenia<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

“…There were no significant differences in the proportion of patients who completed the entire trial while blinded and receiving study drug (39.3% of patients assigned to haloperidol vs 45.9% assigned to olanzapine; P=. 25) …”

The effects of second-generation antipsychotics on cognitive functioning and psychosocial outcome in schizophrenia

“…Such trials are needed to provide proof that enhancing cognitive function via antipsychotic drug treatment really improves psychosocial functioning. Indirect clues that this may be a valid assumption have been provided by Rosenheck et al (1998) and Marder (2000), who have reported that clozapine or risperidone, respectively, improved effects of psychosocial interventions.…”

Clozapine and Haloperidol in Moderately Refractory Schizophrenia

“…16 Rosenheck et al 17 report that clozapine facilitates psychosocial treatment participation, enhancing effects on quality of life and long-term symptom outcome.…”