Does parity worsen diabetes-related chronic complications in women with type 1 diabetes?

Gomes, Marília Brito; Negrato, Carlos Antônio; Almeida, Ana Paula F.; León, Antônio Ponce de

doi:10.4239/wjd.v7.i12.252

Cited by 5 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Korea has also experienced a gradual increase in the incidence rate of diabetes from an estimated less than 1% in 1970 to an estimated 8%-10% in 2000 [19]. Chronic serious complications in the diabetic patients occur as diseases of retina, kidney, peripheral neuron, and peripheral blood vessels [20]. Although there exist various chemicals for improving insulin resistance clinically, such long-term treatments are associated with side effects such as hypoglycemia, obesity, and other diabetes complications [21].…”

Section: Resultsmentioning

confidence: 99%

Characterization of the Bombyx mori homolog of islet homeostasis protein (IHoP) cDNA: BmIHoP controls insulin secretion from the β-cells

Shin¹,

Kwon²,

Choi³

et al. 2018

biomedicalresearch

View full text Add to dashboard Cite

Islet homeostasis protein (IHoP) was firstly characterized as a novel protein that regulates glucagon synthesis in alpha-cells of pancreatic islet. Here, we report a cDNA designed BmIHoP encoding an IHop homolog cloned from the fat body of the silkworm, Bombyx mori, using conserved domain homology search method. The resultant BmIHoP translated into a protein that encodes 693 amino acids, with a theoretical isoelectric point of 5.15 and a molecular weight of 77.5 kDa. Homology analysis revealed that BmIHoP has higher similarity at the amino acid level with those of other species, 52% identity with H. sapiens, 52% with M. musculus, 51% with D. rerio, and 73% with D. melanogaster. The expression of BmIHoP was detected in all tissues tested with 4 fold higher expression in the midgut, Malpighian, ovary and testis, and stronger expression in the larval fat body at 5 th-3 rd instar. The overexpression of BmIHoP in the β-cells reduced insulin secretion, which is not associated with SOX17 regulation. To the best of our knowledge, this is the first report of B. mori IHoP cDNA, BmIHoP, and its associated role in controlling insulin secretion from the β-cells.

show abstract

Section: Resultsmentioning

confidence: 99%

Characterization of the Bombyx mori homolog of islet homeostasis protein (IHoP) cDNA: BmIHoP controls insulin secretion from the β-cells

Shin¹,

Kwon²,

Choi³

et al. 2018

biomedicalresearch

View full text Add to dashboard Cite

show abstract

“…1 , 9 In the longer term, pregnancy as an event does not appear to have a significant effect on the eventual severity of DR and other microvascular diabetic complications. 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

The utility of wide-field optical coherence tomography angiography in diagnosis and monitoring of proliferative diabetic retinopathy in pregnancy

Wright¹,

Khalid

Keane

2022

American Journal of Ophthalmology Case Reports

View full text Add to dashboard Cite

Purpose Diabetic retinopathy is an increasingly common complication of diabetes mellitus that benefits from early diagnosis and frequent monitoring, especially in pregnancy where there is a greater risk of progression. Fundus fluorescein angiography is currently the gold standard method of investigation for neovascularization. However, this has risks of unpleasant and potentially dangerous side effects, with an added theoretical risk to the fetus in pregnancy. Wide-field optical coherence tomography angiography (PLEX Elite 9000, Carl Zeiss Meditec, Inc. USA and DRI Swept Source OCT Triton, Topcon Medical Systems, Inc. USA) potentially offers a safer, faster and equally effective alternative method for diagnosis and monitoring of diabetic retinopathy in pregnant patients. Observations In the 3 cases reviewed from our clinic, we found that wide-field optical coherence tomography angiography was successfully used as an alternative to fundus fluorescein angiography in early diagnosis and ongoing monitoring of diabetic retinopathy in pregnant patients. Conclusions and importance Wide-field optical coherence tomography angiography can be considered as a useful alternative to fundus fluorescein angiography when reviewing pregnant diabetic retinopathy patients. This allows avoidance of any unpleasant and potentially dangerous side effects associated with fluorescein injection, and appears to be just as effective in diagnosis and detecting disease progression.

show abstract

Association of hypertension with parity and with the interaction between parity and body mass index in rural Chinese women

Liu

Zhang²,

Liu³

et al. 2018

Journal of the American Society of Hypertension

View full text Add to dashboard Cite

Does parity worsen diabetes-related chronic complications in women with type 1 diabetes?

Cited by 5 publications

References 23 publications

Characterization of the Bombyx mori homolog of islet homeostasis protein (IHoP) cDNA: BmIHoP controls insulin secretion from the β-cells

Characterization of the Bombyx mori homolog of islet homeostasis protein (IHoP) cDNA: BmIHoP controls insulin secretion from the β-cells

The utility of wide-field optical coherence tomography angiography in diagnosis and monitoring of proliferative diabetic retinopathy in pregnancy

Association of hypertension with parity and with the interaction between parity and body mass index in rural Chinese women

Contact Info

Product

Resources

About