Does parental tuberculosis infection increase the risk of asthma in their offspring? A Norwegian registry-based study

López-Cervantes, J P; Shigdel, Rajesh; Mustafa, Tehmina; Svanes, Cecilie

doi:10.1183/13993003.congress-2021.pa824

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“…Preconception infections altering the health of offspring is supported by a study from López-Cervantes et al using Norwegian registry data that investigated the timing of parental tuberculosis infection in relation to the offspring’s birth year and the association with offspring asthma. The study revealed an increased risk of asthma in the offspring of parents who had a diagnosis of tuberculosis in childhood and later preconception, as compared to those whose parents had tuberculosis after they were born [ 85 ]. The authors theorize that tuberculosis-induced epigenetic reprograming might alter parental immunity, which could alter the offspring type 2 immunity characteristics.…”

Section: Preconception Exposures and Respiratory Health: Evidence From Multigeneration Studies On Humansmentioning

confidence: 99%

The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

López-Cervantes

Lønnebotn

Jõgi

et al. 2021

IJERPH

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Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases have a multifactorial origin in which environmental and lifestyle factors are likely to interact. Traditional exposure assessment methods fail to capture the interactions among environmental exposures and their impact on fundamental biological processes, as well as individual and temporal factors. A valid estimation of exposure preconception is difficult since the human reproductive cycle spans decades and the access to germ cells is limited. The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. An exposome approach implies a targeted or agnostic analysis of the concurrent and temporal multiple exposures, and may, together with recent technological advances, improve the assessment of the environmental contributors to health and disease. This review describes the current knowledge on preconception environmental exposures as related to respiratory health outcomes in offspring. We discuss the usefulness and feasibility of using an exposome approach in this research, advocating for the preconception exposure window to become included in the exposome concept.

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Section: Preconception Exposures and Respiratory Health: Evidence From Multigeneration Studies On Humansmentioning

confidence: 99%

The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

López-Cervantes

Lønnebotn

Jõgi

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

Does parental tuberculosis infection increase the risk of asthma in their offspring? A Norwegian registry-based study

Cited by 1 publication

References 0 publications

The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

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