Does Papillary Carcinoma of Thyroglossal Duct Cyst Develop De Novo?

Bağlam, Tekin; Binnetoğlu, Adem; Yumuşakhuylu, Ali Cemal; Demir, Berat; Askan, Gokce; Sarı, Murat

doi:10.1155/2015/382760

Cited by 7 publications

(8 citation statements)

References 16 publications

(22 reference statements)

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“…Ninety‐eight articles met the inclusion criteria and were included in the final analysis with a total population of 164 patients. Eighty‐one case reports and 17 case series were included 4–101 . The largest case series included 18 patients, and the studies that we evaluated spanned from 1986 to 2016.…”

Section: Resultsmentioning

confidence: 99%

Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes

Rayess

Monk

Svider

et al. 2017

Otolaryngol.--head neck surg.

115

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Objective Although thyroglossal duct cysts (TGDCs) are relatively common, malignancies within these lesions are infrequent. As a result, there are no large-scale series describing clinical characteristics. Our objectives were to perform a systematic review of the literature evaluating patient demographics, pathology, management, and prognosis of these patients. Data Sources PubMed, Embase, Cochrane reviews, and Google Scholar were searched for relevant articles. Articles meeting inclusion criteria were reviewed for data detailing epidemiology, treatment, and outcomes. Review Methods Inclusion criteria included English-language articles with original reports on human subjects. Two investigators independently reviewed all articles for the data collected, including epidemiology, treatment, and outcomes. Results Ninety-eight articles comprising 164 patients were included in the final analysis. The mean age at presentation was 39.5 years (9-83 years); 68.3% of patients were female. In total, 73.3% of cases were found on final pathologic analysis. The most common pathology was papillary cancer (92.1%). Of the patients, 98.9% underwent a Sistrunk procedure and 61.0% underwent total thyroidectomy. There was a 4.3% recurrence rate with a mean time to recurrence of 42.1 months from initial treatment. One patient died of TGDC carcinoma, while all other patients were disease free at the time of last follow-up (mean follow-up was 46.1 months). Conclusion TGDC carcinoma is typically diagnosed on final pathology. While management encompasses a Sistrunk procedure, further consideration should be given to thyroidectomy among patients ≥45 years of age and individuals with aggressive disease. TGDC carcinoma harbors an exceedingly low rate of mortality.

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Section: Resultsmentioning

confidence: 99%

Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes

Rayess

Monk

Svider

et al. 2017

Otolaryngol.--head neck surg.

115

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“…Theories on the development of carcinomas in the TGC may be de novo in the thyroid remnants present in the TGC. 4 These are termed primary TGCCa and secondary are metastasis from papillary carcinomas of the thyroid gland. Other possible causes may be the multifocal origin of carcinomas in genetically predisposed individuals.…”

Section: Discussionmentioning

confidence: 99%

Management of the Thyroid Gland in Papillary Carcinoma of the Thyroglossal Cyst: A Case Report

et al. 2020

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Carcinoma arising in a thyroglossal cyst is rare. We present a case of anterior neck swelling diagnosed to be thyroglossal cyst clinically which turns out to be a papillary carcinoma arising in thyroglossal cyst. She underwent sistrunk procedure with total thyroidectomy and diseasefree on follow up evaluation. Even though preoperative ultrasonography had shown thyroid nodule, the final histology did not show malignancy. There is a paucity of clear-cut guidelines in the management of the thyroid gland in a thyroglossal cyst carcinoma. In thyroglossal cyst carcinoma cases, we recommend thyroidectomy only when there is a thyroid nodule with high-risk features.

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“…Other authors refer to the possibility of TGDCCa representing a distant metastasis of a pre-existing thyroid carcinoma within the thyroid gland itself. [ 11 ] Consequently, many authors recommend more extensive therapy for TGDCCa with at least total thyroidectomy often followed by radioiodine ablation. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

Ectopic papillary thyroid carcinoma within a thyroglossal duct cyst

Roehlen

Takacs²,

Ebeling

et al. 2017

Medicine

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Rationale:Ectopic thyroid carcinoma within a thyroglossal duct cyst (TGDCCa) is an extremely rare entity. Thus, there is no unified appropriate therapeutic strategy, and individual approaches are controversial.Patients concerns:We report the case of a 21-year old woman who underwent Sistrunk procedure for a thyroglossal duct cyst (TGDC).Diagnoses:During histological evaluation of the resected TGDC a papillary thyroid carcinoma was found.Interventions:Due to a tumor size of 1cm and proximity to the surgical border, Sistrunk procedure was extended by total thyroidectomy, followed by radioiodine ablation.Outcomes:Except of minimal follicular hyperplasia, the histological examination of the resected thyroid gland was unsuspicious.Lessons:Therapeutic management of TGDCCa is of interdisciplinary debate due to relative infrequence of the disease and consequently lack of unified therapeutic guidelines. We suggest a personalized therapeutic approach adjusted to individual risk stratification. In young patients with small tumor size and with confirmation of TGDCCa representing the primary tumor, Sistrunk procedure alone may reflect adequate treatment. In all other cases, total thyroidectomy and radioiodine ablation should be evaluated. Overall TGDCCa have an excellent prognosis with a 5-year survival rate of more than 90%.

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Does Papillary Carcinoma of Thyroglossal Duct Cyst Develop De Novo?

Cited by 7 publications

References 16 publications

Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes

Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes

Management of the Thyroid Gland in Papillary Carcinoma of the Thyroglossal Cyst: A Case Report

Ectopic papillary thyroid carcinoma within a thyroglossal duct cyst

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