Does oxidative stress correlate with disease activity and severity in vitiligo? An analytical study

Mathachan, Sinu Rose; Khurana, Ananta; Gautam, R. K.; Kulhari, Anita; Sharma, Lokesh Kumar; Sardana, Kabir

doi:10.1111/jocd.13499

Cited by 15 publications

(9 citation statements)

References 41 publications

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“…In the literature, data on the oxidant-antioxidant balance in vitiligo are confusing; some authors have identified differences between vitiligo patients and the control group, and others have not [ 102 , 103 ]. The meta-analysis by Xiao et al highlighted a positive correlation between low levels of GPX and vitiligo [ 104 ].…”

Section: Discussionmentioning

confidence: 99%

Thiol-Disulfide Homeostasis in Skin Diseases

Georgescu

Mitran

et al. 2022

JCM

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Oxidative stress represents the imbalance between oxidants and antioxidants and has been associated with a wide range of diseases. Thiols are the most important compounds in antioxidant defense. There is an equilibrium between thiols and their oxidized forms, disulfides, known as dynamic thiol-disulfide homeostasis (TDH). In 2014, Erel and Neselioglu developed a novel automated assay to measure thiol and disulfide levels. Subsequently, many researchers have used this simple, inexpensive and fast method for evaluating TDH in various disorders. We have reviewed the literature on the role of TDH in skin diseases. We identified 26 studies that evaluated TDH in inflammatory diseases (psoriasis, seborrheic dermatitis, atopic dermatitis, vitiligo, acne vulgaris and rosacea), allergic diseases (acute and chronic urticaria) and infectious diseases (warts, pityriasis rosea and tinea versicolor). The results are heterogeneous, but in most cases indicate changes in TDH that shifted toward disulfides or toward thiols, depending on the extent of oxidative damage.

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Section: Discussionmentioning

confidence: 99%

Thiol-Disulfide Homeostasis in Skin Diseases

Georgescu

Mitran

et al. 2022

JCM

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“…The aforementioned information on the immunopathogenesis of vitiligo indicates that vitiligo may be initiated by metabolic stress due to ROS accumulation, particularly in the affected areas, suggesting that the use of antioxidants may have a potential therapeutic implication for the damaged oxidative pathways (92).…”

Section: Immunopathogenesis Of Vitiligomentioning

confidence: 99%

Novel immunological and genetic factors associated with vitiligo: A review

et al. 2021

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Vitiligo is a skin disorder characterized by depigmentation of the skin due to a lack of melanin. This condition affects men and woman of all ages and its incidence is not restricted by ethnicity or region. Vitiligo is a multifactorial disease, in which melanocytes, which serve important functions in skin pigmentation and immune processes, are impaired. There is sufficient evidence that immunological and genetic factors are primarily responsible for the destruction and dysfunction of melanocytes. Therefore, genetic DNA sequence variants that participate in skin homeostasis, pigmentation and immune response regulation, as well as altered expression patterns, may contribute to the risk of developing vitiligo. The current review presented an overview of the mechanism of pigmentation and of currently known factors involved in depigmentation, as well as the classification, epidemiology, associated comorbidities, risk factors, immunopathogenesis and several genetic and molecular changes associated with vitiligo. Contents 1. Overview 2. Immunopathogenesis of vitiligo 3. Genetic factors associated with vitiligo 4. Conclusions

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“…Function as antioxidants, good results of antioxidants in combination with phototherapy. [113][114][115][116][117][118][119] Level 1b…”

Section: Evidence For the Role Of Diet In Vitiligo Level Of Evidencementioning

confidence: 99%

Role of nutritional supplements in selected dermatological disorders: A review

Sardana

Sachdeva

2021

J of Cosmetic Dermatology

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Background While a plethora of literature continues to be published on the role of nutritional agents both in lay press and indexed journals, the data is not on a firm footing and leaves the dermatologist in a quandry and the patient confused. The various agents include vitamins, minerals, amino acids, antioxidants, diets & gluten. A proper knowledge of the role of nutritional supplements in dermatological diseases can be a useful tool in advising the patients and in certain cases ameliorating the disorder. Patients/Methods Literature review of last 15 years was made using the terms “diet in dermatology,” “nutrition and skin,” “nutritional supplements in dermatology,” “nutritional agents and acne,” “nutritional agents and alopecia,” and “nutritional agents and psoriasis.” Results While there are multiple publications on the use of nutritional supplements for amelioration of skin diseases, most of them are based on either associations or in vitro studies, but very few transcend the rigors of a clinical trial or the holey grail of a double‐blinded randomized controlled trial. There seem to be some evidence in acne, psoriasis, telogen effluvium, urticaria & vitiligo. Coeliac disease and dermatitis herpetiformis have a strong link with diet. Rosacea has a strong link with certain foods, but the other disorders like melasma, aphthous stomatitis do not have any scientifically validated association with diet. Conclusions Our updated review examines the role of nutritional supplements and antioxidants in various dermatological disorders. We have found that there are varying levels of evidence with notable associations of low glycemic diet & acne, fish oil & weight loss with psoriasis, fish oils & probiotics with atopic dermatitis & vitamins & botanical extracts with vitiligo. The evidence for diet and nutrition in bullous disorders and photoageing is scarce. The role of low histamine diet in urticaria is useful in select cases of episodic urticaria. Rosacea is triggered by hot and spicy food . Apart from gluten and Dermatitis Herpetiformis, no diet can be considered disease modifying in our reveiw. The lack of comparison of nutritional or dietary modiffication with conventional validated agents, makes the data difficult to translate in real world patient management.

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Does oxidative stress correlate with disease activity and severity in vitiligo? An analytical study

Cited by 15 publications

References 41 publications

Thiol-Disulfide Homeostasis in Skin Diseases

Thiol-Disulfide Homeostasis in Skin Diseases

Novel immunological and genetic factors associated with vitiligo: A review

Role of nutritional supplements in selected dermatological disorders: A review

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