Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor?

Shukla, Nilima; Maher, J.M.; Masters, Joseph M.; Angelini, Gianni; Jeremy, Jamie Y.

doi:10.1016/j.atherosclerosis.2005.11.035

Cited by 124 publications

(129 citation statements)

References 125 publications

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“…awadallah et al [33] explained that increased levels of cu and ceruloplasmin in the sera of patients with cardiovascular disease was caused by intensification of the inflammatory process, a primary factor in atherogenesis. according to Shukla et al [31], an increased level of cu in cardiovascular disease, as well as in diabetes, is associated with the effect of ROS, which block the attachment of cu to ceruloplasmin. cu ions are necessary to enable proper activity of c cytochrome, antioxidant enzymes such as dismutase, metallothionein and other cellular oxidases.…”

Section: Cuznsodmentioning

confidence: 98%

“…Patients with either type of diabetes developed higher levels of cu in extracellular spaces. These higher levels, along with the presence of ceruloplasmin, play a role in the oxidative modification of LDL-c particles [21,31,32]. awadallah et al [33] explained that increased levels of cu and ceruloplasmin in the sera of patients with cardiovascular disease was caused by intensification of the inflammatory process, a primary factor in atherogenesis.…”

Section: Cuznsodmentioning

confidence: 99%

“…The activity of erythrocyte cuZnSOD depends on two elements: cu and Zn. Per Shukla et al [31] suggested that in many diseases associated with chronic oxidative stress, including diabetes, ROS impair the function of cuZn -SOD by replacing the intracellular cu ions found in protein compounds, eg, in metallothionein and also in SOD. another explanation for decreased cuZnSOD activity is a Zn deficiency in the erythrocytes of patients with diabetes [26].…”

Section: Intra-erythrocyte Antioxidant Enzymes and Tasmentioning

confidence: 99%

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Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Salmonowicz¹,

Krzystek−Korpacka²,

Noczyńska³

2014

Adv Clin Exp Med

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Background. Magnesium (Mg), selinium (Se), zinc (Zn), manganese (Mn), and copper (cu) are involved in the mechanisms of antioxidant defense. Mn and cu, which participate in the generation of reactive oxygen species (ROS), also have pro-oxidative properties. Objectives. To evaluate the levels of Mg, Se, Zn, Mn, and cu, as well as the effectiveness of antioxidant defense mechanisms in children with Type 1Diabetes Mellitus (T1DM) and in their siblings. The preliminary findings were originally reported in 2009 at the 35 th annual conference of the International Society for Pediatric and adolescent Diabetes (ISPaD) in Ljubljana, Slovenia. Material and Methods. The study involved 87 children with T1DM, 2-19 years old, treated for T1DM for an average of 3.5 years. The sibling and control groups comprised 27 and 41 children, aged 4.5-16.5 years and 10.5-18 years respectively. The parameters named above were assessed in relation to metabolic compensation levels (Hb a1c ) and disease duration. Results. compared with the control group, T1DM children had lower plasma levels of Mg and Zn and higher levels of cu; the siblings had lower levels of Zn; T1DM children had lower copper/zinc superoxide dismutase (cuZnSOD) activity; and both T1DM children and their siblings had higher catalase (caT) activity and lower total antioxidant status (TaS) levels. Conclusions. There may be a correlation between impaired antioxidant status and Mg and Zn deficiency and increased cu levels in T1DM children. Oxidative stress in T1DM is accompanied by alterations in enzymatic activity and non-enzymatic mechanisms of antioxidant defense. The decreased TaS levels noted in T1DM patients may impair the effectiveness of non-enzymatic antioxidant systems. The increased caT activity and unimpaired selenium-dependent glutathione peroxidase (Se-GSHPx) activity point indirectly to enhanced ROS generation in T1DM children. The impaired antioxidant defense found in the siblings of T1DM patients may indicate that genetic factors play a role (Adv Clin Exp Med 2014, 23, 2, 259-268).

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Section: Cuznsodmentioning

confidence: 98%

Section: Cuznsodmentioning

confidence: 99%

Section: Intra-erythrocyte Antioxidant Enzymes and Tasmentioning

confidence: 99%

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Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Salmonowicz¹,

Krzystek−Korpacka²,

Noczyńska³

2014

Adv Clin Exp Med

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“…These systems include antioxidant proteins such as superoxide dismutase (SOD), heme oxygenase-1, and ceruloplasmin [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Ionizing irradiation induces apoptotic damage of salivary gland acinar cells via NADPH oxidase 1-dependent superoxide generation

Tateishi

Sasabe

Ueta

et al. 2008

Biochemical and Biophysical Research Communications

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“…Elevated circulating CP levels are associated with cardiovascular disease (CVD) [8]. There is also evidence that the risk factors for CVD, in particular, diabetes mellitus and hyperhomocysteinaemia, may augment the vasculopathic impact of CP [9]. Another possibility is for reactive oxygen species to disrupt copper bound to CP, thereby impairing the protective function of the latter, while liberating copper, which in turn may promote oxidative reactions [9] .…”

Section: Introductionmentioning

confidence: 99%

Ceruloplasmin and oxidized LDL colocalize in atherosclerotic lesions of hamster

Stancu¹,

Constantinescu²,

Sima³

2010

Open Life Sciences

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Epidemiological studies show that the risk for cardiovascular diseases increases with increasing levels of free-copper in plasma. It is known that intact ceruloplasmin (CP), the major protein transporter of copper in human plasma, oxidizes low density lipoproteins (LDL) in vitro. Our aim was to study the interaction between LDL and CP in vitro and in vivo, in an animal model of diet-induced atherosclerosis. In order to visualize the pathway of LDL into the arterial wall, human native LDL was labeled with fluorescent DiI and injected into male, Golden Syrian hyperlipemic hamsters. In vitro results demonstrated that slightly degraded CP has a significant oxidation potential against LDL at neutral pH. In vivo, after 24 hours circulation, LDL-DiI was taken up by the enlarged intima and fatty streaks of the arterial wall. Immunohistochemical localization of oxidized LDL and CP revealed their presence in the same areas of the arteries that take up LDL-DiI. Co-localization of LDL and CP in the enlarged intima of pro-atherosclerotic areas might explain the possible copper-induced oxidation process that might occur after native LDL is taken-up from the blood, transcytosed through the endothelium and accumulated in focalized deposits.

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Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor?

Cited by 124 publications

References 125 publications

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Ionizing irradiation induces apoptotic damage of salivary gland acinar cells via NADPH oxidase 1-dependent superoxide generation

Ceruloplasmin and oxidized LDL colocalize in atherosclerotic lesions of hamster

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