This study aims to examine the effects of ownership structure on the profitability of banks in Indonesia. The structure of bank ownership is divided into three categories, namely government, private domestic, and foreign ownership. Bank profitability is measured by Return on Assets (ROA) and Return on Equity (ROE). This research uses bank size as a control variable. We use explanatory survey for this study. The sampling technique used is the purposive sampling method. We use secondary data obtained from the Indonesian Financial Services Authority and annual reports from each bank. We then analyze the data using panel regression testing with common effect modeling. The results show that private domestic and foreign ownership have statistically significant positive effects on bank profitability, while government ownership has a statistically significant negative effect on bank profitability.