Does osteoporosis predispose falls? a study on obstacle avoidance and balance confidence

Smulders, Ellen; Lankveld, Wim van; Laan, Roland; Duysens, Jacques; Weerdesteyn, Vivian

doi:10.1186/1471-2474-12-1

Cited by 71 publications

(76 citation statements)

References 42 publications

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“…Recently, osteoporosis has been recognized as a diabetic complication [7][8][9]. Several studies have shown that osteoporosis is associated with a risk of falls because osteoporotic fractures, such as hip and vertebral fractures, cause imbalance and decreased physical performance [19][20][21]. However, no studies have examined the association between the risk of falls and fractures in patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Association between the risk of falls and osteoporotic fractures in patients with type 2 diabetes mellitus

et al. 2017

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FALLING is a major health concern among elderly people because it increases the incidence of fractures and causes a deterioration in mobility. It is reported that one in three people over 65 years of age fall at least once per year and that half of elderly people over 80 years of age experience at least one fall per year [1][2][3]. Moreover, the severity of fall-related complications increases with aging. Fractures are one of the most serious fall-related injuries and can lead to a loss of independence through disability and fear of falling. The reduction in mobility and independence is a serious issue in aging societies because it often results in admission to a hospital or nursing home and can potentially result in premature death. Additionally, diabetes mellitus (DM) is known to be associated with an Department of Medicine, Diabetes, Metabolism and Endocrinology, Matsuyama Red Cross Hospital, Japan Abstract. Diabetes mellitus is associated with an increased risk of falls, which increases the incidence of osteoporotic fractures and accordingly decreases quality of life. However, the association between fall risk and diabetic complications is not completely understood. Therefore, the aim of this study was to examine the association between fall risk and osteoporotic fractures in patients with type 2 diabetes mellitus (T2DM). We enrolled 194 Japanese patients with T2DM and assessed their fall risk using a brief interview form that included five items covering physical and social aspects of functioning and environmental factors. We examined the associations between fall risk and the presence of diabetic complications, such as neuropathy, retinopathy, nephropathy, cardiovascular disease, cerebrovascular disease, peripheral artery disease (PAD), and osteoporotic fractures (including any fracture and vertebral fractures only). In the multivariate logistic regression analysis, a longer history of T2DM, the presence of neuropathy and PAD, and a history of any fractures were significantly and positively associated with the risk of falls. On the other hand, a lower body mass index, the presence of neuropathy, and the risk of falls were independently and positively associated with the risk of any fracture. When fractures were limited to vertebral fractures only, the association with the risk of falls remained significant. We found that the risk of falls and osteoporotic fractures were associated in patients with T2DM and that a brief screening test of the risk of falls was useful for assessing the risk of osteoporotic fractures.Key words: Fall, Osteoporosis, Fracture, Neuropathy, Type 2 diabetes mellitus increased risk of falling [4][5][6]. Therefore, it is no less important to assess the risk of falls in diabetic patients than it is in their non-diabetic counterparts. Osteoporosis has been recognized as one of the complications of DM. Accumulating evidence shows that patients with DM have an increased risk of osteoporotic fractures independently of their bone mineral density (BMD) [7][8][9]. Several meta-analyses ha...

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Section: Discussionmentioning

confidence: 99%

Association between the risk of falls and osteoporotic fractures in patients with type 2 diabetes mellitus

et al. 2017

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“…Glavni cilj vežbanja kod žena u postmenopauzi je da se poveća mišićna masa, poboljšaju parametri mišićne funkcije − snaga i balans, koji su važni faktori rizika za pad i nezavisno od koštane gustine, faktori rizika za prelom [18]. Vežbe jačanja mišića obavljaju se elastičnim trakama, mašinama, tegovima i drugim izometrijskim vežbama.…”

Section: Adaptirana Fizička Aktivnostunclassified

Adapted physical activity in the prevention and therapy of osteoporosis

Boskovic

Protić-Gava²,

Grajic

et al. 2013

Med pregl

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“…However, a study by Hunter et al [2010] did not find an association between IMD and the premutation. There is evidence both for [Behm et al, 2012] and against fibromyalgia being an IMD [Schmidt-Wilcke et al, 2011; Üçeyler at al., 2011] but the cytokine profiles are disturbed in patients with fibromyalgia and such disturbances are common in those with the premutation because of miRNA dysfunction as described below [Sellier et al, 2013]. …”

Section: Introductionmentioning

confidence: 99%

Immune mediated disorders in women with a fragile X expansion and FXTAS

Jalnapurkar

Rafika

Tassone

et al. 2014

American J of Med Genetics Pt A

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Premutation alleles in FMR1 can cause the late-onset neurodegenerative disorder, fragile X-associated tremor ataxia syndrome (FXTAS) and/or the fragile X-associated primary ovarian insufficiency in approximately 20% of heterozygotes. Heterozygotes of the FMR1 premutation have a higher incidence of immune mediated disorders such as autoimmune thyroid disorder, especially when accompanied by FXTAS motor signs. We describe the time course of symptoms of immune mediated disorders and the subsequent development of FXTAS in four women with an FMR1 CGG expansion, including three with the premutation and one with a gray zone expansion. These patients developed an immune mediated disorder followed by neurological symptoms that become consistent with FXTAS. In all patients we observed a pattern involving an initial appearance of disease symptoms – often after a period of heightened stress (depression, anxiety, divorce, general surgery) followed by the onset of tremor and/or ataxia. Immune mediated diseases are associated with the manifestations of FXTAS temporally, although further studies are needed to clarify this association. If a cause and effect relationship can be established, treatment of pre-existing immune mediated disorders may benefit patients with pathogenic FMR1 mutations.

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Does osteoporosis predispose falls? a study on obstacle avoidance and balance confidence

Cited by 71 publications

References 42 publications

Association between the risk of falls and osteoporotic fractures in patients with type 2 diabetes mellitus

Association between the risk of falls and osteoporotic fractures in patients with type 2 diabetes mellitus

Adapted physical activity in the prevention and therapy of osteoporosis

Immune mediated disorders in women with a fragile X expansion and FXTAS

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