Does Osteoarthritis Of The Knee Also Have A Psychogenic Component? Psycho-emotional Treatment With a Radio-electric Device vs. Intra-articular Injection Of Sodium Hyaluronate: An Open-label, Naturalistic Study

Castagna, Alessandro; Rinaldi, Salvatore; Fontani, Vania; Aravagli, Lucia; Mannu, Piero; Margotti, Matteo Lotti

doi:10.3727/036012910803860968

Cited by 20 publications

(25 citation statements)

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“…REAC treatment has proved its efficacy in ameliorating several stress-related disorders,1,6–9 depression,5,9,10 anxiety,5,9 bipolar disorders,4 and also in some forms of dementias3 and impaired motor control 18,20. The REAC procedure is painless, and no adverse effects from its use have been reported.…”

Section: Methodsmentioning

confidence: 99%

“…Images are usually separated by 1–4 seconds, and the stimuli or the cognitive and motor tasks are carried out during the fMRI session. It has previously been observed that the changes in psychological1,3–10 and motor behavior activity18–20 resulting from radioelectric asymmetric conveyor (REAC) brain stimulation pulse (BSP) stimulation are relatively long lasting, the persistence of effects has been observed for a few years. Although the duration of the REAC stimulus is brief (500 milliseconds), it was hypothesized that changes in brain activity following stimulation would be observable using fMRI, despite the low temporal resolution of this imaging modality.…”

Section: Introductionmentioning

confidence: 99%

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Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study

Rinaldi¹,

Fontani²,

Castagna³

2011

NDT

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PurposeRadioelectric asymmetric brain stimulation technology with its treatment protocols has shown efficacy in various psychiatric disorders. The aim of this work was to highlight the mechanisms by which these positive effects are achieved. The current study was conducted to determine whether a single 500-millisecond radioelectric asymmetric conveyor (REAC) brain stimulation pulse (BSP), applied to the ear, can effect a modification of brain activity that is detectable using functional magnetic resonance imaging (fMRI).MethodsTen healthy volunteers, six females and four males, underwent fMRI during a simple finger-tapping motor task before and after receiving a single 500-millisecond REAC-BSP.ResultsThe fMRI results indicate that the average variation in task-induced encephalic activation patterns is lower in subjects following the single REAC pulse.ConclusionThe current report demonstrates that a single REAC-BSP is sufficient to modulate brain activity in awake subjects, able to be measured using fMRI. These initial results open new perspectives into the understanding of the effects of weak and brief radio pulses upon brain activity, and provide the basis for further indepth studies using REAC-BSP and fMRI.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study

Rinaldi¹,

Fontani²,

Castagna³

2011

NDT

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“…The neuropsychophysical optimization protocol induces a new positive regulation of bioelectric activity in the central nervous system, leading to normalization of brain function that can be tailored to the individual,22–34,38 according to symptoms of pain and physical problems. The current study was designed based upon the results of a previous study that demonstrated the beneficial effects of REAC in stress-related disorders,24 and was targeted to assess specific stress-related clusters on the PSM test 25.…”

Section: Discussionmentioning

confidence: 99%

“…REAC-specific treatments have proven efficacious in ameliorating stress-related disorders,22–25 depression,26 anxiety,25,27 bipolar disorder,28 and other psychiatric disorders 29. REAC administration has also been shown to be effective in treating neuromotor dysfunction,30 posttraumatic pain and injury,31,32 and improving functional recovery in arthritic lower limb joints 33,34. REAC utilized a typical range of frequencies of 2.4, 5.8, or 10.5 gHz, as selected by the operator for each specific protocol.…”

Section: Methodsmentioning

confidence: 99%

Noninvasive radioelectric asymmetric brain stimulation in the treatment of stress-related pain and physical problems: psychometric evaluation in a randomized, single-blind placebo-controlled, naturalistic study

Fontani¹,

Rinaldi²,

Aravagli³

et al. 2011

IJGM

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BackgroundThe aim of this study was to investigate the effects of noninvasive radioelectric asymmetric conveyer brain stimulation (REAC-BS) on pain and physical problems, a measurement cluster of the Psychological Stress Measure (PSM) test. When the symptoms of pain and physical problems do not respond to various therapeutic approaches such as medication, physiotherapy, and psychotherapy, they are often called medically unexplained symptoms. As such, these symptoms are reported to be a response to stressful situations or emotional states, often unknown to patients themselves. To explore the effectiveness of noninvasive radioelectric brain stimulation in the amelioration of symptoms of pain and physical problems, we administered a neuropsychophysical optimization protocol using a REAC device.MethodsThe PSM, a self-administered questionnaire, was used to measure psychological stress and pain and physical problems in a group of 888 subjects. Data were collected immediately prior to and following a 4-week REAC treatment cycle.ResultsThere was a significant reduction in scores measuring subjective perceptions of stress for subjects treated with one cycle of neuropsychophysical optimization REAC-BS. At the end of the study, the number of treated subjects reporting symptoms of stress-related pain and physical problems on the PSM test was significantly reduced, whereas there was no difference in placebo-treated subjects.ConclusionOne cycle of neuropsychophysical optimization REAC-BS appears to reduce subjective perceptions of stress as measured by the PSM, particularly on the pain and physical problems cluster.

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“…Excluding some psychotherapies,44–47 at the moment, no data are available about other therapeutical approaches such as noninvasive brain stimulation techniques like radio electric asymmetric conveyor (REAC) treatments. Neuro psycho physical optimization (NPPO)-REAC has demonstrated efficacy in improving certain psychiatric disorders such as stress-related disorders,48–53 anxiety,53,54 depression,53–55 bipolar disorder,56 and behavioral and psychiatric symptoms in Alzheimer disease. 57 The main goal of the present study was to investigate the efficacy of NPPO-REAC in the treatment of gSAD in patients who refuse drug treatment.…”

Section: Introductionmentioning

confidence: 99%

Social anxiety disorder: radio electric asymmetric conveyor brain stimulation versus sertraline

Fontani¹,

Mannu²,

Castagna³

et al. 2011

PPA

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PurposeSocial anxiety disorder (SAD) is a disabling condition that affects almost 5% of the general population. Many types of drugs have shown their efficacy in the treatment of SAD. There are also some data regarding psychotherapies, but no data are available today about the efficacy of brain stimulation techniques. The aim of the study is to compare the efficacy of noninvasive brain stimulation neuro psycho physical optimization (NPPO) protocol performed by radio electric asymmetric conveyor (REAC) with that of sertraline in adults with SAD.Patients and methodsTwenty SAD patients on sertraline were compared with 23 SAD patients who refused any drug treatment and who chose to be treated with NPPO-REAC brain stimulation. This was a 6-month, open-label, naturalistic study. Patients on sertraline received flexible doses, whereas NPPO-REAC patients received two 18-session cycles of treatment. Clinical Global Improvement scale items “much improved” or “very much improved” and Liebowitz Social Anxiety Scale total score variation on fear and avoidance components were used to detect the results. The statistical analysis was performed with t-test. All measures <0.05 have been considered statistically significant.ResultsTen of 23 subjects on NPPO-REAC and six of the 20 taking sertraline were much improved or very much improved 1 month after the first NPPO-REAC cycle (t1). Sixteen of the subjects on NPPO-REAC and ten of the subjects taking sertraline were much improved or very much improved 1 month after the second NPPO-REAC cycle (t2). In respect of the Liebowitz Social Anxiety Scale, at t1 NPPO-REAC resulted in statistically more efficacy for sertraline on both fear and avoidance total scores. At t2, NPPO-REAC resulted in statistically more efficacy for sertraline on fear but not on avoidance.ConclusionNPPO-REAC is an effective treatment for SAD, allowing substantial and clinically meaningful reductions in symptoms and disability in comparison with sertraline.

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Does Osteoarthritis Of The Knee Also Have A Psychogenic Component? Psycho-emotional Treatment With a Radio-electric Device vs. Intra-articular Injection Of Sodium Hyaluronate: An Open-label, Naturalistic Study

Cited by 20 publications

References 0 publications

Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study

Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study

Noninvasive radioelectric asymmetric brain stimulation in the treatment of stress-related pain and physical problems: psychometric evaluation in a randomized, single-blind placebo-controlled, naturalistic study

Social anxiety disorder: radio electric asymmetric conveyor brain stimulation versus sertraline

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