Abstract:Orexins A (OXA) and B (OXB) and the receptors 1 (OX1R) and 2 (OX2R) for orexins are hypothalamic peptides found in several mammalian organs and participated to the control of a wide assortment of physiological and pathological functions. The distribution of OXA and OX1R has been extensively studied in the male gonad of mammals. Here, we examined the expression and localization of OXB and OX2R as well as their possible involvement in the regulation of testicular and epididymal functions, in healthy and cryptorc… Show more
“…In contrast, OXA alone occurred in the early germ cells [ 94 ], while OXB was found in a sub-population of Leydig cells (intermingled among the negative ones), in pachytene and zygotene spermatocytes, in secondary spermatocytes, and from immature to mature spermatids in the seminiferous tubule of normal dogs. In contrast, OXB occurred in Sertoli and Leydig cells and rarely in early gonocytes of cryptorchid dogs [ 15 ].…”
Section: The Orexinergic System In the Male Genital Tract Of Dogmentioning
confidence: 99%
“…OXB- and OX2R-IR have been described in all stages of the germ-developing cycle by Soares et al [ 98 ]. In the cryptorchid testis, OX2R occurred mainly in Leydig and Sertoli cells [ 15 ].…”
Section: The Orexinergic System In the Male Genital Tract Of Dogmentioning
confidence: 99%
“…In addition, OXB and OX2R have been evidenced in seminiferous and interstitial compartments of dog testes [ 15 ].…”
Section: The Orexinergic System In the Male Genital Tract Of Dogmentioning
confidence: 99%
“…Epididymis : OXB has been found in all segments of the principal cells, both in normal and cryptorchid animals. In contrast, OX2R was only localized in the efferent ductules in the head of normal and cryptorchid epididymis [ 15 ].…”
Section: The Orexinergic System In the Male Genital Tract Of Dogmentioning
confidence: 99%
“…The OX/HCRT system has mainly been described in laboratory animals [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ] and in humans, both in healthy and cancerous stages, using different techniques [ 17 , 18 , 19 , 20 ].…”
Orexins A (OXA) and B (OXB) and their specific receptors, receptor 1 (OX1R) and 2 (OX2R) for orexins, are hypothalamic peptides involved in orchestrating several functions in the central nervous system and peripheral organs, including sleep, excitement, nutrition, reward, circadian rhythm, anxiety, cognition, and reproduction. The aim of this narrative review is, in particular, to speculate the role of orexins in the male genital tract of animal species and human beings. The experimental evidence collected in recent years assumed that in the testes of the animal species here described, orexins are directly involved in steroidogenesis and spermatogenesis regulation. In the epididymis, these peptides are locally synthesized, thus suggesting their role governing the fertilizing capability of the immature male gamete. In addition to playing a physiological role, orexins are involved in numerous inflammatory and/or neoplastic pathologies too. The expression of the orexinergic system in prostate cancer suggests that they might play a potential therapeutic function. Overall, the future directions of this literature review allow us to hypothesize a role of the orexinergic complex not only as a marker for the diagnosis of certain tumors affecting the male genital tract but also for the treatment of hypo/infertility condition.
“…In contrast, OXA alone occurred in the early germ cells [ 94 ], while OXB was found in a sub-population of Leydig cells (intermingled among the negative ones), in pachytene and zygotene spermatocytes, in secondary spermatocytes, and from immature to mature spermatids in the seminiferous tubule of normal dogs. In contrast, OXB occurred in Sertoli and Leydig cells and rarely in early gonocytes of cryptorchid dogs [ 15 ].…”
Section: The Orexinergic System In the Male Genital Tract Of Dogmentioning
confidence: 99%
“…OXB- and OX2R-IR have been described in all stages of the germ-developing cycle by Soares et al [ 98 ]. In the cryptorchid testis, OX2R occurred mainly in Leydig and Sertoli cells [ 15 ].…”
Section: The Orexinergic System In the Male Genital Tract Of Dogmentioning
confidence: 99%
“…In addition, OXB and OX2R have been evidenced in seminiferous and interstitial compartments of dog testes [ 15 ].…”
Section: The Orexinergic System In the Male Genital Tract Of Dogmentioning
confidence: 99%
“…Epididymis : OXB has been found in all segments of the principal cells, both in normal and cryptorchid animals. In contrast, OX2R was only localized in the efferent ductules in the head of normal and cryptorchid epididymis [ 15 ].…”
Section: The Orexinergic System In the Male Genital Tract Of Dogmentioning
confidence: 99%
“…The OX/HCRT system has mainly been described in laboratory animals [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ] and in humans, both in healthy and cancerous stages, using different techniques [ 17 , 18 , 19 , 20 ].…”
Orexins A (OXA) and B (OXB) and their specific receptors, receptor 1 (OX1R) and 2 (OX2R) for orexins, are hypothalamic peptides involved in orchestrating several functions in the central nervous system and peripheral organs, including sleep, excitement, nutrition, reward, circadian rhythm, anxiety, cognition, and reproduction. The aim of this narrative review is, in particular, to speculate the role of orexins in the male genital tract of animal species and human beings. The experimental evidence collected in recent years assumed that in the testes of the animal species here described, orexins are directly involved in steroidogenesis and spermatogenesis regulation. In the epididymis, these peptides are locally synthesized, thus suggesting their role governing the fertilizing capability of the immature male gamete. In addition to playing a physiological role, orexins are involved in numerous inflammatory and/or neoplastic pathologies too. The expression of the orexinergic system in prostate cancer suggests that they might play a potential therapeutic function. Overall, the future directions of this literature review allow us to hypothesize a role of the orexinergic complex not only as a marker for the diagnosis of certain tumors affecting the male genital tract but also for the treatment of hypo/infertility condition.
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