Does omethoate have the potential to cause insulin resistance?

Zhang, Yunjian; Ren, Mingchun; Qian, Wenyuan; Ren, Zhixing; Lv, Jingmao; Niu, Fenglan; Ren, Shengxiang

doi:10.1016/j.etap.2013.11.030

Cited by 11 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, a recent study revealed that the increment of immune cells may be a consequence of the increased expression of cytokines, including IL-1, IL-6 and IFN-γ in the liver of rats exposed to malathion ( 82 ). Moreover, Zhang et al demonstrated enhanced levels of malondialdehyde, TNF-α and IL-6 in the muscles of rats exposed to omethoate, a commonly used insecticide in developing countries ( 83 ). The authors concluded with the postulation that omethoate has a potential to cause insulin resistance.…”

Section: Diabetesmentioning

confidence: 99%

Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases (Review)

Gangemi

Gofita

Costa

et al. 2016

International Journal of Molecular Medicine

149

View full text Add to dashboard Cite

Pesticides can exert numerous effects on human health as a consequence of both environmental and occupational exposures. The available knowledge base suggests that exposure to pesticides may result in detrimental reproductive changes, neurological dysfunction and several chronic disorders, which are defined by slow evolution and long-term duration. Moreover, an ever increasing amount of data have identified an association between exposure to pesticides and the harmful effects on the immune system. The real impact of alterations in humoral cytokine levels on human health, in particular in the case of chronic diseases, is still unclear. To date, studies have suggested that although exposure to pesticides can affect the immune system functionally, the development of immune disorders depends on the dose and duration of exposure to pesticides. However, many of the respective studies exhibit limitations, such as a lack of information on exposure levels, differences in the pesticide administration procedures, difficulty in characterizing a prognostic significance to the weak modifications often observed and the interpretation of obtained results. The main challenge is not just to understand the role of individual pesticides and their combinations, but also to determine the manner and the duration of exposure, as the toxic effects on the immune system cannot be separated from these considerations. There is a clear need for more well-designed and standardized epidemiological and experimental studies to recognize the exact association between exposure levels and toxic effects and to identify useful biomarkers of exposure. This review focuses on and critically discusses the immunotoxicity of pesticides and the impact of cytokine levels on health, focusing on the development of several chronic diseases.

show abstract

Section: Diabetesmentioning

confidence: 99%

Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases (Review)

Gangemi

Gofita

Costa

et al. 2016

International Journal of Molecular Medicine

149

View full text Add to dashboard Cite

show abstract

“…[ 29 ] Although we could not find epidemiological evidence for dimethoate even after PubMed search with the following terms “Dimethoate” [MESH] AND “Diabetes” [MESH], we were able to find animal studies implicating omethoate (a break-down product of dimethoate) with insulin resistance. [ 30 ] The epidemiological evidences are summarized in Table 6 . Major limitation of the study is the cross-sectional nature, which might not have captured the cause-effect relationship.…”

Section: Discussionmentioning

confidence: 99%

Persistent organic pollutants-environmental risk factors for diabetes mellitus? – A population-based study

Ramalingam

Narayanan

Muthusamy

et al. 2021

Indian J Occup Environ Med

View full text Add to dashboard Cite

Background: Globally, type-2 diabetes mellitus is increasing in epidemic proportions. A major cause of concern in India is the increasing incidence of cases, especially troubling is the observed increase in younger age groups with no risk factors. New evidence suggests that many environmental factors, such as air pollution, persistent organic pollutants (POPs), and environmental estrogens are implicated as risk factors for type-2 diabetes mellitus. Animal and human epidemiological studies have shown ubiquitous lipophilic substances, including POPs, are frequently associated with type-2 diabetes mellitus. Such studies have not been undertaken in Indian youth. Methods: This is a cross-sectional study that explored the association between POPs and type-2 diabetes mellitus in Indian urban and rural population. About 7 ml of venous blood was collected from all consenting patients and serum was separated immediately and was transported to the lab for further analysis. Serum levels of POPs, including organochlorine (OC) compounds and organophosphorus pesticides, were estimated using sample gas chromatography-mass spectrometry (GC-MS). The fasting blood sugar values and the serum levels of POPS were tested using Pearson correlation coefficient. The magnitude of increase in blood sugar corresponding to increase in POPs was analyzed using linear regression analysis. The odds ratios (ORs) were expressed at 95% confidence intervals (CIs). Results: Three OC pesticides and one organophosphate pesticide were strongly associated with increasing blood sugar levels after adjusting for age, sex, and body mass index – lindane (OR 4.95, 95% CI 1.03–23.73), DDT o, p' (OR 3.50, 95% CI 1.04–11.73), dimethoate (OR 19.31, 95% CI 4.22–88.37), and dichlorvas (OR 6.33, 95% CI 1.28–31.18).

show abstract

“…Additionally, Zhang et al pointed out that omethoate (1.5, 3, and 6 mg/kg body through the stomach for 2 months) increased MDA, IL-6, and TNF-α levels and decreased SOD and GPx activities in the right thigh muscles of rats by activating JNK, p38-MAPK, and master transcription factor NF-κB in the right thigh muscles, leading to insulin resistance. ERK1/2 is a major factor involved in insulin signaling, and an increase in these levels disrupts the insulin signaling pathway [66]. In a study by Mense et al, CPF and cyfluthrin significantly increased the levels of activated ERK1/2 in primary human fetal astrocytes, suggesting that CPF and cyfluthrin increased the inflammation markers IL-6 and GFAP similar to the signaling component ERK1/2 [67].…”

Section: Organophosphorus Compounds-induced Hyperglycemia Are Mediatementioning

confidence: 99%

Organophosphorus Compounds and MAPK Signaling Pathways

Farkhondeh

Buhrmann

Pourbagher‐Shahri

et al. 2020

IJMS

View full text Add to dashboard Cite

The molecular signaling pathways that lead to cell survival/death after exposure to organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated protein kinases (MAPKs) including the extracellular signal-regulated protein kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and the p38-MAPK play the leading roles in the transmission of extracellular signals into the cell nucleus, leading to cell differentiation, cell growth, and apoptosis. Moreover, exposure to OPCs induces ERK, JNK, and p38-MAPK activation, which leads to oxidative stress and apoptosis in various tissues. However, the activation of MAPK signaling pathways may differ depending on the type of OPCs and the type of cell exposed. Finally, different cell responses can be induced by different types of MAPK signaling pathways after exposure to OPCs.

show abstract

Does omethoate have the potential to cause insulin resistance?

Cited by 11 publications

References 36 publications

Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases (Review)

Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases (Review)

Persistent organic pollutants-environmental risk factors for diabetes mellitus? – A population-based study

Organophosphorus Compounds and MAPK Signaling Pathways

Contact Info

Product

Resources

About