Does Off-pump Coronary Revascularization Reduce the Release of the Cerebral Markers, S-100β and NSE?

Release of Serum S-100.BETA. Protein and Neuron-Specific Enolase after Off-Pump Coronary Artery Bypass Grafting with and without Intracranial and Cervical Artery Stenosis

“…Bonacchi M et al reported that the maximum value of the s-100β protein was 1.4 ± 0.4 μg/l and NSE was 17.7 ± 6.5 μg/l for patients with CPB. 7) Similarly, Anderson RE et al reported that the maximum value of the s-100β protein was 2.4 ± 1.5 μg/l for patients with CPB after operation. 5) Compared to these reports, the patients in the present study displayed relatively slight increases in s-100β protein and NSE, even those patients with arterial stenosis.…”

“…Bonacchi M et al demonstrated that coronary artery bypass surgery without cardiopulmonary bypass causes a significantly greater decrease in s-100β protein and NSE levels than conventional coronary artery bypass surgery. 7) Anderson RE et al demonstrated that CABG with CPB caused a 10-fold increase in s-100β protein than OPCAB. 5) It is highly unlikely that the effect of heparin, cross-clamping, side-biting clamps, and aortic cannulation can account for the difference in s-100β protein release.…”

“…17, No. 1 (2011) (OPCAB) is better than conventional CABG [5][6][7] at reducing the incidence of neurologic complications [1][2][3][4] and release of s-100β protein and NSE.…”

Off-pump Coronary Artery Bypass Does Not Influence Biomarkers of Brain Injury, But Does Exacerbate the Systemic Inflammatory Response

“…However, Diegelers randomized trial demonstrated cognitive impairment in 90% of CCAB patients and none in the OPCAB, albeit these findings may be attributed to its limited sample size (n=40). Mazzei et al [12] in a randomized trial comparing minimal extracorporeal circulation to off-pump reported a non-significant reduction in S100β in the OPCAB group, whereas Bonacchi et al [13] reported a statistically significant reduction in S100β among patients undergoing OPCAB compared to CCAB (0.5+/-0.11 versus 1.38+/-0.4 (microg/l), p<0.001). While patients undergoing CCAB may have higher exposure to microemboli, patients undergoing OPCAB may be exposed to an increased burden of hypotention or cerebral hypoperfusion during the construction of the posterior distal anastomoses [14,15].…”

Neurocognitive dysfunction after cardiac surgery and biochemical markers

“…[46] ameliyat sonrası S100b proteini düzeyinin atan kalpte KABG'de, KPB ile CABG'ye oranla (pulsatil ya da non-pulsatil akım uygulanan) daha düşük olduğu ve perfüzyon türünden etkilenmediğini bildirmişlerdir. Bonacchi ve ark., [47] KPB ile [48] göre pulsatil perfüzyonun KPB ve sonrasında S100b salınımına anlamlı bir etkisi bulunmamaktadır. Fakat bu araştırmaların aksine, Kusch ve ark.…”