Does obesity modify the relationship between physical activity and breast cancer risk?

Neil-Sztramko, Sarah; Boyle, Terry; Milosevic, Elizabeth; Nugent, Sean F.; Gotay, Carolyn; Campbell, Kristin L.

doi:10.1007/s10549-017-4449-4

Cited by 20 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[27][28][29] A recent meta-analysis of 18 cohort and 11 case-control studies found that self-reported physical activity was associated with the greatest magnitude reduction in breast cancer risk among women with lower BMI, and that there was no significant association between self-reported physical activity and breast cancer risk among women who were obese. 5 One factor that may partly explain the lack of risk reduction associated with physical activity in some studies is the over-reporting of physical activity among individuals with higher BMI. 30 In our analyses, the decreased risk associated with physical activity did not appear to vary by BMI and this lack of variation in association with BMI is consistent with that from a recent study that pooled data from 10 prospective cohorts with self-reported physical activity as the exposure and incident breast cancer as the outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have also reported greater reductions in risk associated with physical activity among postmenopausal women 1 and those with a relatively low body mass index (BMI), 5 but it is unclear as to what extent these observed differences may be attributed to differential reporting bias in self-reported estimates of physical activity by subgroups of menopausal status and BMI, as opposed to genuine effect modification.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Physical activity and breast cancer risk: results from the UK Biobank prospective cohort

et al. 2020

View full text Add to dashboard Cite

BACKGROUND: Previous studies suggest a protective role of physical activity in breast cancer risk, largely based on self-reported activity. We aimed to clarify this association by examining breast cancer risk in relation to self-reported physical activity, informed by accelerometer-based measures in a large subset of participants. METHODS: We analysed data from 47,456 premenopausal and 126,704 postmenopausal women in UK Biobank followed from 2006 to 2014. Physical activity was self-reported at baseline, and at resurvey in a subsample of 6443 participants. Accelerometer data, measured from 2013 to 2015, were available in 20,785 women. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated by using multivariable-adjusted Cox regression. RESULTS: A total of 3189 cases were diagnosed during follow-up (mean = 5.7 years). Women in the top compared with the bottom quartile of self-reported physical activity had a reduced risk of both premenopausal (RR 0.75; 95% CI 0.60-0.93) and postmenopausal breast cancer (RR 0.87; 95% CI 0.78-0.98), after adjusting for adiposity. In analyses utilising physical activity values assigned from accelerometer measurements, an increase of 5 milli-gravity was associated with a 21% (RR 0.79; 95% CI 0.66-0.95) reduction in premenopausal and a 16% (RR 0.84; 95% CI 0.73-0.96) reduction in postmenopausal breast cancer risk. CONCLUSIONS: Greater physical activity is associated with a reduction in breast cancer risk, which appears to be independent of any association it may have on risk through its effects on adiposity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physical activity and breast cancer risk: results from the UK Biobank prospective cohort

et al. 2020

View full text Add to dashboard Cite

show abstract

“…(6) The updated search identified two meta-analyses on the associations between physical activity and breast cancer risk, both of which reported reduced breast cancer risk comparing high versus low levels of physical activity for the total population, (12,13) although one meta-analysis found no association of physical activity with breast cancer occurring before menopause. (12) The updated search identified five publications of cohort studies (14-18) that investigated the associations of physical activity with breast cancer risk. One cohort study observed that strenuous activity was inversely and significantly associated with reduced breast cancer risk, particularly in certain molecular subtypes.…”

Section: Cancer Primary Preventionmentioning

confidence: 99%

Physical Activity in Cancer Prevention and Survival: A Systematic Review

McTiernan

Friedenreich

Katzmarzyk

et al. 2019

Medicine &Amp; Science in Sports &Amp; Exercise

611

398

View full text Add to dashboard Cite

This paper is being published as an official pronouncement of the American College of Sports Medicine. This pronouncement was reviewed for the American College of Sports Medicine by members-at-large and the Pronouncements Committee. Disclaimer: Care has been taken to confirm the accuracy of the information present and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this publication and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of this information in a particular situation remains the professional responsibility of the practitioner; the clinical treatments described and recommended may not be considered absolute and universal recommendations.

show abstract

“…In addition, physical activity reduces circulating leptin and insulin levels, and insulin resistance while increasing adiponectin, IGFBP-1 and IGFBP-3 levels (19)(20)(21). These influence the associations between the insulin pathway and breast cancer development and progression (11,16,17,(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Leisure-Time Physical Activity is Associated with reduced Risk of Breast Cancer and Triple Negative Breast Cancer in Nigerian Women: a matched case-control study

Bigman

Adebamowo

Yawe

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Physical activity is associated with reduced risk of breast cancer and its various subtypes but this association is less known in African women, particularly with triple-negative breast cancer that occurs more frequently in Sub-Saharan Africa compared to developed countries. In this study, we examined the association between leisure-time physical activity (LTPA) and breast cancer in total and by its subtypes in Nigerian women. Methods Overall, 630 newly diagnosed patients with primary invasive breast cancer were age-matched (±5years) with 630 controls from the Nigerian Integrative Epidemiology of Breast Cancer (NIBBLE) Study from 01/2014-07/2016. We derived the average amount of time spent on LTPA per week over the past year using a modified Nurses’ Health Study-II physical activity questionnaire. We calculated the total metabolic equivalents (METs) for each reported LTPA per hour/week (i.e. walking, cycling, and dancing) and compared odds of breast cancer among participants who attained the World Health Organization (WHO) physical activity(PA) recommendations of at least 150 minutes of moderate-intensity or/and 75 minutes of vigorous-intensity aerobic activity/week with those who did not. In addition, we evaluated this by categories of LTPA in quartiles of METs. We used conditional and unconditional logistic regression models to estimate the adjusted Odds Ratio(OR) of LTPA with overall breast cancer and by hormone receptor-positive and triple-negative breast cancer. Results The mean ages of cases and controls were similar after matching, 42.5±10.1 and 41.5±9.2 years (mean±SD), respectively. Women who attained the WHO PA recommendations had a 42% reduction in the odds of having breast cancer(OR=0.58 95% CI:0.43-0.78) compared with those who did not. LTPA was associated with reduced odds of having hormone receptor-positive by 41% and significantly associated with reduced odds of having triple-negative breast cancer by 45%. In addition, a significant dose-response relationship was observed, women with higher levels of LTPA had lower odds of having overall breast cancer as well as having triple-negative and hormone receptor-positive breast cancer. Conclusions Increasing LTPA in African women can play a significant role in reducing the incidence of breast cancer, particularly of the more aggressive subtype as triple-negative, which is more prevalent in Sub-Saharan Africa.

show abstract

Does obesity modify the relationship between physical activity and breast cancer risk?

Cited by 20 publications

References 27 publications

Physical activity and breast cancer risk: results from the UK Biobank prospective cohort

Physical activity and breast cancer risk: results from the UK Biobank prospective cohort

Physical Activity in Cancer Prevention and Survival: A Systematic Review

Leisure-Time Physical Activity is Associated with reduced Risk of Breast Cancer and Triple Negative Breast Cancer in Nigerian Women: a matched case-control study

Contact Info

Product

Resources

About