Does neutrophil to lymphocyte ratio demonstrate deterioration in renal function?

Abstract

Introduction: Chronic kidney disease (CKD) is a major health issue worldwide, which leads to end-stage renal failure and cardiovascular events. Neutrophil to lymphocyte ratio (NLR) is a surrogate marker of inflammation and has been widely studied in malignancies, hypertension, heart diseases, and vascular diseases. In this study, we aimed to investigate if NLR represents renal reserve and function after partial or radical nephrectomy.Methods: We conducted a retrospective study consists of patients who had undergone radical/partial nephrectomy in our hospital and/or who admitted to urology and nephrology clinics as an outpatient. Patients were divided into four groups: Group 1 (n = 46): Healthy controls; Group 2 (n = 50): Patients who had undergone unilateral partial nephrectomy; Group 3 (n = 46): Patients who had gone unilateral nephrectomy; Group 4 (n = 82): Patients who had CKD.Results: The mean NLR of each group was as follows: Group 1: 2.14 ± 0.73; Group 2: 3.52 ± 3.74; Group 3: 3.64 ± 3.52, and Group 4: 3.53 ± 2.30. NLR was lower in Group 1 compared to other groups but statistically significant difference was observed only between Group 1 (control) and Group 4 (CKD), 2.14 ± 0.73 versus 3.53 ± 2.30 (p = .005). In non-parametric correlation analysis NLR was found negatively correlated with GFR and positively correlated CKD stage (p = .028 for both correlations).Conclusions: The NLR may constitute a practical predictor of CKD besides Cr in patients who had undergone partial or radical nephrectomy.

Correlation between neutrophil‐to‐lymphocyte ratio and kidney dysfunction in undiagnosed hypertensive population from general health checkup

“…Similar mean NLR numbers were found in 132 participants without HTN was 1.69 and in 30 healthy subjects was 1.75 . In another study by Tonyali et al, mean NLR from 46 healthy controls was 2.14 and the level was increased significantly in chronic kidney disease (to 3.52). Similar increment in NLR was observed in disease conditions .…”

Neutrophil-to-lymphocyte ratio and mortality in the United States general population

“…A recent meta-analysis showed a predictive ability of NLR for acute exacerbations in patients with chronic obstructive pulmonary disease 39 . Similarly, the prognostic value of NLR in kidney disease progression has been reported 40,41 . Although we did not observe an overall linear trend, high quartiles of NLR (quartiles 2, 3, and 4 vs. 1) had elevated HRs for mortality due to Alzheimer's disease.…”

Effects of neutrophil–lymphocyte ratio on renal function and histologic lesions in patients with diabetic nephropathy

“…In the past couple of years, many studies have proved that the chronic inflammation was significantly associated with the development and prognosis of DN, hence, it is important to search the related biomarkers to help identify patients at risk of ESKD in a relatively early stage. Neutrophil–lymphocyte ratio (NLR) is regarded as a novel indicator for inflammation and its association with heart failure, coronary artery disease and chronic kidney disease has been reported in many studies. However, the role of NLR in the development of DN has still been elusive.…”