Does neuroanatomy account for superior temporal dysfunction in early psychosis? A multimodal MRI investigation

Pettersson-Yeo, William; Benetti, Stefania; Frisciata, Silvia; Catani, Marco; Williams, Steven; Allen, Paul; McGuire, Philip; Mechelli, Andrea

doi:10.1503/jpn.140082

Cited by 5 publications

(1 citation statement)

References 53 publications

(66 reference statements)

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“…The broad array of symptoms, cognitive impairment, and functional deficits suggest that numerous brain regions may mediate the psychopathology of this disorder. Indeed, previous functional (Lawrie et al, 2002;Manoach et al, 2000;Ragland et al, 2007;Vincent et al, 2008) and structural (Kubicki et al, 2007;Pettersson-Yeo et al, 2015;Wheeler et al, 2015) brain mapping studies have confirmed the involvement of multiple regions throughout cortical and subcortical networks.…”

Section: Introductionmentioning

confidence: 74%

Functional network connectivity in early-stage schizophrenia

Hummer

Yung

Goñi

et al. 2020

Schizophrenia Research

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Section: Introductionmentioning

confidence: 74%

Functional network connectivity in early-stage schizophrenia

Hummer

Yung

Goñi

et al. 2020

Schizophrenia Research

View full text Add to dashboard Cite

Neuroimaging and the At-Risk Mental State

Lin

Fusar‐Poli

Borgwardt

2019

Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders

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Intrinsic functional connectivity of fronto-temporal networks in adolescents with early psychosis

Solé‐Padullés

Castro‐Fornieles

Serna

et al. 2016

Eur Child Adolesc Psychiatry

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Adults with psychotic disorders have abnormal connectivity of fronto-temporal networks. However, whether these abnormalities are present in adolescents with early psychosis has not been fully assessed. One-hundred and thirty-nine adolescents aged 12-18 underwent resting-state functional magnetic resonance imaging and diffusion tensor imaging. Following motion correction, data were available for 44 participants with a psychosis risk syndrome, 34 patients with a first episode psychosis (FEP) and 35 healthy controls. Independent component analysis was performed to assess functional networks showing a fronto-temporal scope; this identified a language and a salience network. Mean fractional anisotropy was measured in clusters showing between-group differences in intrinsic functional connectivity (iFC). For the language network, there was a group effect within the right middle/inferior frontal gyrus, explained by reduced iFC in patients with an FEP relative to healthy controls, while in participants with a psychosis risk syndrome values of iFC were intermediate. In this region, values of iFC were positively correlated with mean fractional anisotropy in patients with an FEP. No group differences were observed in the salience network. Reduced iFC of the language network, in association with disrupted white matter microstructure, may characterize FEP during adolescence.

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Does neuroanatomy account for superior temporal dysfunction in early psychosis? A multimodal MRI investigation

Cited by 5 publications

References 53 publications

Functional network connectivity in early-stage schizophrenia

Functional network connectivity in early-stage schizophrenia

Neuroimaging and the At-Risk Mental State

Intrinsic functional connectivity of fronto-temporal networks in adolescents with early psychosis

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