Does neoplasia in-situ develop due to the interaction of Epstein-Barr virus of herpes simplex virus-2 with Langerhans cells in the epithelium?

Becker, Yechiel

doi:10.1007/bf00257101

Virus Genes

1988

DOI: 10.1007/bf00257101

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Does neoplasia in-situ develop due to the interaction of Epstein-Barr virus of herpes simplex virus-2 with Langerhans cells in the epithelium?

Yechiel Becker

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1990

1993

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Cited by 2 publications

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“…The Epstein Barr virus (EBV) is known to be oncogenic at various sites (Burkitt 1958; Epstein & Achong 1979), especially in the presence of immunosuppression (Daniels et al 1987), and has also been isolated from cervical smears and washings taken from women with CIN (sixbey et al 1986; Bevan et al 1989). A causative role has been proposed for herpes simplex virus (HSV) (Rawls et al 1978) although doubt has been cast upon this hypothesis (Becker et al 1988).…”

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Is HIV infection associated with an increase in the prevalence of cervical neoplasia?

Smith

Kitchen²,

Botcherby³

et al. 1993

BJOG

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Objective To test the hypotheses: that HIV infection predisposes to cervical intraepithelial neoplasia (CIN); that this CIN is a result of HIV related immunosuppression; and that this CIN is a result of immunosuppression causing increased expression of the potentially oncogenic viruses, human papilloma virus (HPV), Epstein Barr virus (EBV) and herpes simplex virus (HSV). Design A matched cross sectional study. Setting The Department of Gynaecological Oncology, The Samaritan Hospital, London; the Department of Genitourinary Medicine, St Mary's Hospital, London; and the Family Planning Clinic, Claremont Terrace, Glasgow. Subjects Fifty HIV seropositive women enrolled from the Genitourinary Medicine Department and the Drug Dependency Unit at St Mary's Hospital, London, and the Unit of Infectious Diseases at Ruchill Hospital, Glasgow. Forty‐three HIV seronegative controls enrolled from the Department of Genitourinary Medicine at St Mary's Hospital, matched against 43 of the seropositive women for age, age at first intercourse, lifetime number of sexual partners, and smoking habit. Main outcome measures Associations between CIN, as detected by cytology and histology, and HIV infection. Association was also sought between CIN and immunosuppression, as measured clinically by T4 cell number, β‐2‐microglobulin and p24 antigen. Associations of these with: (1) HPV, as detected by Southern blot testing and the polymerase chain reaction; (2) EBV, as detected by Southern blot testing; and (3) HSV, as detected by tissue culture of endocervical swabs, was also studied. Results There was no significant difference in the prevalence of CIN or oncogenic viruses between HIV seropositive and seronegative women in the absence of immunosuppression. If the HIV infected women showed signs of immunosuppression, the prevalence of CIN was increased. No association was shown between detection of HPV, EBV and HSV and immunosuppression or CIN. Conclusion HIV infection may only be associated with an increased risk of CIN when immunosuppression is present.

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confidence: 99%

Is HIV infection associated with an increase in the prevalence of cervical neoplasia?

Smith

Kitchen²,

Botcherby³

et al. 1993

BJOG

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Rationale for Anti-AIDS Chemotherapy Directed at HIV-1 Infected Dendritic Cells in Seropositive Individuals Prior to the Appearance of ARC and AIDS

Becker

1990

Journal of Chemotherapy

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An approach to anti-AIDS chemotherapy is presented from the point of view of treating seropositive individuals by eliminating the infected dendritic cells that are the in vivo target of HIV-1. Special attention is given to the treatment of Langerhans (dendritic) cells in the skin and epithelia that are infected in vivo by HIV and are involved in the development of the symptoms leading to AIDS and ARC. Since HIV is released through the cervical and vaginal epithelia in seropositive women, it is suggested that combined local treatment of vaginal epithelium with steroids that inactivate dendritic cells and azidothymidine (AZT) that inhibits HIV-1 replication might prevent virus dissemination. Abrogation of HIV-1 transmission will help to prevent its spread throughout the heterosexual population. Thus a new rationale for anti-AIDS treatment is presented, namely selective elimination of HIV-1 infected dendritic cells in the skin and epithelia of infected individuals before the appearance of ARC or AIDS. Subsequent restoration of dendritic cells in HIV-1-infected persons (and in AIDS patients) by means of orally administered retinoids in combination with an antiviral drug might be a useful approach to prevent or delay AIDS.

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Does neoplasia in-situ develop due to the interaction of Epstein-Barr virus of herpes simplex virus-2 with Langerhans cells in the epithelium?

Cited by 2 publications

References 78 publications

Is HIV infection associated with an increase in the prevalence of cervical neoplasia?

Is HIV infection associated with an increase in the prevalence of cervical neoplasia?

Rationale for Anti-AIDS Chemotherapy Directed at HIV-1 Infected Dendritic Cells in Seropositive Individuals Prior to the Appearance of ARC and AIDS

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