Does multiple sclerosis increase risk of adverse pregnancy outcomes? A population-based study

Chen, Y-H.; Lin, Herng-Ching; Lin, Horng Chyuan

doi:10.1177/1352458508101937

Cited by 74 publications

(78 citation statements)

References 21 publications

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“…In contrast, in population-based studies from Norway, women with MS were at increased risk of cesarean delivery (though planned and not due to emergencies) and giving birth to SGA babies or with lower mean birth weight [74]. An increased risk of SGA babies and cesarean delivery was also detected in a population-based study from Taiwan [75]. In addition, Taiwanese MS patients were more likely to have preterm delivery.…”

Section: Prevalence Isotype Distribution and Clinical Associations mentioning

confidence: 73%

The implications of autoimmunity and pregnancy

Borchers

Naguwa

Keen

et al. 2010

Journal of Autoimmunity

167

122

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Section: Prevalence Isotype Distribution and Clinical Associations mentioning

confidence: 73%

The implications of autoimmunity and pregnancy

Borchers

Naguwa

Keen

et al. 2010

Journal of Autoimmunity

167

122

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“…34 The effect of MS on pregnancy outcome includes increased risk of fetal growth restriction (odds ratio 35 These findings were confirmed in a smaller Taiwanese study (nϭ174), which, unlike the U.S. study, also found an increase in preterm birth (OR 2.25, 95% CI 1.37-3.70). 36 The mechanisms for increased rates of adverse pregnancy outcomes in women with MS are not clear.…”

Section: Multiple Sclerosismentioning

confidence: 99%

Pregnancy in Women With Physical Disabilities

Signore

Spong

Krotoski

et al. 2011

Obstetrics &Amp; Gynecology

123

107

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The Eunice Kennedy Shriver National Institute of Child Health and Human Development sponsored a 2-day workshop to assess the body of evidence on pregnancy in women with physical disabilities, identify gaps in knowledge, and formulate recommendations for further research. A multidisciplinary group of experts discussed available data on pregnancy outcomes among women with varying physically disabling conditions, medical and psychosocial risks for mothers and children, and barriers to prenatal care and parenting for women with physical disabilities. Existing evidence is limited by a preponderance of retrospective single-site studies of small sample sizes. For most women, pregnancy outcomes are favorable. However, increased rates of certain adverse outcomes, such as low birth weight (related to preterm birth or growth restriction) and cesarean delivery, have been reported in women with spinal cord injuries, rheumatoid arthritis, multiple sclerosis, or other conditions. Common morbidities across conditions may include urinary tract infections, decreased mobility and independence, skin ulceration, respiratory compromise, interpersonal abuse, stress, and mood disorders. Socioeconomic, physical, and attitudinal barriers to antenatal care and independent parenting can be problematic. Current evidence, although limited, indicates that most women with physical disabilities will have good pregnancy outcomes; however, some data suggest that rates of a range of complications may be more common among women with physical disabilities, depending on the nature and severity of the underlying condition. Many questions remain unanswered. Establishment of a systematic and comprehensive registry of pregnancy course and outcomes among women with physical disabilities is of high priority for addressing persistent gaps in knowledge.

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“…These factors included the characteristics of the mother: age (Cleary-Goldman et al, 2005), highest educational level (Chen et al, 2009), marital status (Kirchengast et al, 2007), year of delivery), infant gender (Ingemarsson, 2003;Di Renzo et al, 2007), parity and monthly family income . Maternal age was grouped into the following : ,20, 20 -24, 25 -29, 30 -34, 35-39 and 40.…”

Section: Variables Of Interestmentioning

confidence: 99%

Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study

Chen¹,

Lin²,

Chen³

et al. 2009

Human Reproduction

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background: Using a 3-year nationwide population-based database, this study examines the risk of adverse pregnancy outcomes [lower birthweight, preterm gestation and babies small for gestational age (SGA)] in pregnant women with uterine leiomyoma.methods: This study linked two data sets: Taiwan's birth certificate registry and its National Health Insurance Research Data set. A total of 5627 mothers with uterine leiomyoma and 28 135 unaffected mothers were included for analysis. After adjusting for mother and infant characteristics and monthly family income, log-binominal regression and multivariate regression analyses were conducted to examine the risks of preterm birth, SGA and lower birthweight among mothers with uterine leiomyoma and unaffected mothers.results: Women with uterine leiomyoma had a significantly higher percentage of preterm births (10.98 versus 7.78%, P , 0.001) and SGA infants (19.00 versus 17.28%, P ¼ 0.002) than unaffected mothers. The mean birthweights for mothers with and without uterine leiomyoma were 3083 and 3172 g, respectively (P , 0.001). Log-binominal regression models show that the adjusted risk ratios of preterm births and SGA infants for mothers with uterine leiomyoma were 1.32 (95% CI 1.19 -1.46) and 1.16 (95% CI 1.08 -1.26), respectively, compared with unaffected mothers. After finally adjusting for gestational age and other covariates, a multivariate regression analysis revealed that women with uterine leiomyoma had, on average, a 14.7 g lower birthweight than unaffected mothers (P ¼ 0.022).conclusions: We concluded that after adjusting for potential confounders, women with uterine leiomyoma experience a small yet significant increased risk of preterm and SGA infants. We suggest that clinicians intensively monitor women with uterine leiomyoma during pregnancy.

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Does multiple sclerosis increase risk of adverse pregnancy outcomes? A population-based study

Cited by 74 publications

References 21 publications

The implications of autoimmunity and pregnancy

The implications of autoimmunity and pregnancy

Pregnancy in Women With Physical Disabilities

Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study

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