Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

Orvieto, Raoul; Noach‐Hirsh, Meirav; Segev-Zahav, Aliza; Haas, Jigal; Nahum, Ravit; Aizer, Adva

doi:10.1186/s12958-021-00757-6

Cited by 125 publications

(156 citation statements)

References 20 publications

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“…12,13 To date, only two Israeli studies have focused on the potential correlation between messenger ribonucleic acid (mRNA) COVID-19 vaccine and in vitro fertilization (IVF) outcomes. 14,15 Similar results were found in ovarian response and embryological characteristics between vaccinated and control groups, and one study further reported an acceptable pregnancy rate of 30% in vaccinated women. 15 The authors thus concluded that mRNA COVID-19 vaccine did not influence patients' performance during IVF treatment.…”

Section: Introductionsupporting

confidence: 59%

“…14,15 Similar results were found in ovarian response and embryological characteristics between vaccinated and control groups, and one study further reported an acceptable pregnancy rate of 30% in vaccinated women. 15 The authors thus concluded that mRNA COVID-19 vaccine did not influence patients' performance during IVF treatment. Nonetheless, both studies are of small sample size (<50), and there is still a lack of real-world data on the follow-up of inactivated vaccine administration among infertile patients.…”

Section: Introductionsupporting

confidence: 59%

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No Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study

Huang¹,

Xia²,

Lin³

et al. 2022

JIR

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To investigate the impact of inactivated SARS-CoV-2 vaccination on in vitro fertilization (IVF) outcomes. Patients and Methods: This retrospective cohort study included 2185 patients undergoing fresh IVF cycles from June 1st to September 13th 2021 in a single university-affiliated hospital. Vaccine administration information was collected and ascertained via immunization records. Patients with two dosages of inactivated SARS-CoV-2 vaccines (Sinopharm or Sinovac) were categorized into the vaccinated group (n = 150), while those unvaccinated were classified as control (n = 2035). Propensity score matching was performed to balance the baseline characteristics (14 covariates) between the two groups at a ratio of 1:4. The main outcome measures were the number of oocytes retrieved, good-quality embryo rate and clinical pregnancy rate. Results: There were 146 women in the vaccinated group and 584 in the control group after matching. The number of oocytes retrieved (9.9 ± 7.1 vs 9.9 ± 6.7; P = 0.893), good-quality embryo rate (33.5 ± 29.8% vs 29.9 ± 28.6%; P = 0.184) and clinical pregnancy rate (59.1% vs 63.6%; P = 0.507) were all similar between the two groups. In addition, no significant differences were observed regarding other cycle characteristics, laboratory parameters and pregnancy outcomes. The results were also comparable when vaccinated patients were subdivided into three categories based on the time interval from complete vaccination to cycle initiation: ≤1 month, >1-2 months, and >2 months. Conclusion:Our study provided the first-time evidence that inactivated SARS-CoV-2 vaccination in females did not result in any measurable detrimental effects on IVF treatment. Owing to the present limitations, further prospective studies with larger cohort size and longer follow-up are warranted to validate our conclusion.

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Section: Introductionsupporting

confidence: 59%

Section: Introductionsupporting

confidence: 59%

No Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study

Huang¹,

Xia²,

Lin³

et al. 2022

JIR

View full text Add to dashboard Cite

show abstract

“…For people in the reproductive age group or planning pregnancy, the effect of the COVID-19 vaccine is an important consideration. Fortunately, based on multiple reports, no evidence of an adverse effect on the fertility of women or men has been found [115][116][117][118][119][120].…”

Section: Impact Of Covid-19 Vaccine On Fertilitymentioning

confidence: 99%

COVID-19 Vaccine in Pregnant and Lactating Women: A Review of Existing Evidence and Practice Guidelines

Garg

Shekhar

Sheikh

et al. 2021

Infectious Disease Reports

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Coronavirus 2019 (COVID-19) has created a global pandemic that is devastating human lives, public healthcare systems, and global economies. Multiple effective and safe COVID-19 vaccines have been developed at an unprecedented speed due to the efforts of the scientific community, and collaboration between the federal government and pharmaceutical companies. However, the continued exclusion of pregnant and lactating women from the COVID anti-viral and vaccine trials has created the paradox of a lack of empirical evidence in a high-risk population. Based on the experience of similar prior vaccines, animal developmental and reproductive toxicology studies, and preliminary findings from human studies, various healthcare professional advisory committees (Advisory Committee on Immunization Practices, American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine, and Academy of Breastfeeding Medicine) have issued guidance supporting COVID-19 vaccination in pregnant and lactating women. In this article, we summarize the available data on the efficacy and safety profile of COVID-19 vaccination in pregnant and lactating women, review the challenges of vaccine hesitancy, and include recommendations for healthcare providers.

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“…Similarly, an assessment of follicular steroidogenesis and oocyte quality did not show any measurable difference when compared with unvaccinated women ( Bentov et al , 2021 ). Moreover, Orvieto et al (2021) reported that many IVF treatment parameters, such as the number of oocytes and mature oocytes retrieved, fertilization rate and the ratio of top-quality embryos (TQEs) per fertilized oocyte, did not significantly differ between the pre- and post-BNT162b2 vaccination groups ( Orvieto et al , 2021 ): these researchers had also found that COVID-19 infection could lead to a significantly lower proportion of TQEs ( Orvieto et al , 2021 ). Overall, these primary findings unanimously indicate that vaccination will not result in any measurable detrimental effect on the female or male reproductive system.…”

Section: Impact Of Mrna Vaccination On Human Fertilitymentioning

confidence: 99%

Effects of COVID-19 and mRNA vaccines on human fertility

et al. 2021

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The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions. Because of its severe impact, multiple COVID-19 vaccines are being rapidly developed, approved and manufactured. Among them, mRNA vaccines are considered as ideal candidates with special advantages to meet this challenge. However, some serious adverse events have been reported after their application, significantly increasing concerns about the safety and efficacy of the vaccines and doubts about the necessity of vaccination. Although several fertility societies have announced that COVID-19 mRNA vaccines are unlikely to affect fertility, there is no denying that the current evidence is very limited, which is one of the reasons for vaccine hesitancy in the population, especially in pregnant women. Herein, we provide an in-depth discussion on the involvement of the male and female reproductive systems during SARS-CoV-2 infection or after vaccination. On one hand, despite the low risk of infection in the male reproductive system or fetus, COVID-19 could pose an enormous threat to human reproductive health. On the other hand, our review indicates that both men and women, especially pregnant women, have no fertility problems or increased adverse pregnancy outcomes after vaccination, and, in particular, the benefits of maternal antibodies transferred through the placenta outweigh any known or potential risks. Thus, in the case of the rapid spread of COVID-19, although further research is still required, especially a larger population-based longitudinal study, it is obviously a wise option to be vaccinated instead of suffering from serious adverse symptoms of virus infection.

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Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

Cited by 125 publications

References 20 publications

No Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study

No Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study

COVID-19 Vaccine in Pregnant and Lactating Women: A Review of Existing Evidence and Practice Guidelines

Effects of COVID-19 and mRNA vaccines on human fertility

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