Does MR spectroscopy of normal-appearing cervical spinal cord in patients with multiple sclerosis have diagnostic value in assessing disease progression? A prospective comparative analysis

Basha, Mohammad Abd Alkhalik; Bessar, Manar A.; Ahmed, Ayman; Elfiki, Inas; Elkhatib, Takwa H M; Mohamed, Arwa

doi:10.1016/j.crad.2018.04.018

Cited by 5 publications

(12 citation statements)

References 40 publications

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“…Our findings are largely consistent in terms of NAA and Cho changes with human MS in the brain 11,13 and spinal cord studies 16,17 . Other MS spinal cord studies found no significant change in Cho 9,15,18,19 . Cho was also found to correlate with EAE score, and it was stronger in animals with an EAE score of 3 (Table 1).…”

Section: Discussionsupporting

confidence: 88%

“…Comparison between control and EAE groups showed no significant difference in the Cr, indicating a similar level of energy metabolism 18 . This finding is consistent with that found in human MS in the brain 11,12 and in the spinal cord 18,19 …”

Section: Discussionsupporting

confidence: 86%

“…MS disease in human brain resulted in metabolic changes of N ‐acetyl aspartate (NAA), 11–13 choline (Cho) 11,14 and myo‐inositol (m‐Ins), 13,14 with similar results reported for the human spinal cord 9,10,15–19 . The basal metabolite levels in the brain and spinal cord, however, are different.…”

Section: Introductionsupporting

confidence: 53%

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Multiparametric magnetic resonance imaging for detection of pathological changes in the central nervous system of a mouse model of multiple sclerosis in vivo

et al. 2023

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Multiple sclerosis (MS) is an autoimmune disease involving demyelination and axonal damage in the central nervous system (CNS). In this study, we investigated pathological changes in the lumbar spinal cord of C57BL/6 mice induced with progressive experimental autoimmune encephalomyelitis (EAE) disease using 9.4‐T magnetic resonance imaging (MRI). Multiparametric MRI measurements including MR spectroscopy, diffusion tensor imaging (DTI) and volumetric analyses were applied to detect metabolic changes in the CNS of EAE mice. Compared with healthy mice, EAE mice showed a significant reduction in N‐acetyl aspartate and increases in choline, glycine, taurine and lactate. DTI revealed a significant reduction in fractional anisotropy and axial diffusivity and an increase in radial diffusivity in the lumbar spinal cord white matter (WM), while in the grey matter (GM), fractional anisotropy increased. High‐resolution structural imaging also revealed lumbar spinal cord WM hypertrophy and GM atrophy. Importantly, these MRI changes were strongly correlated with EAE disease scoring and pathological changes in the lumbar (L2–L6), particularly WM demyelination lesions and aggregation of immune cells (microglia/macrophages and astrocytes) in this region. This study identified changes in MRI biomarker signatures that can be useful for evaluating the efficacy of novel drugs using EAE models in vivo.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 86%

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Multiparametric magnetic resonance imaging for detection of pathological changes in the central nervous system of a mouse model of multiple sclerosis in vivo

et al. 2023

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“… Swanberg et al (2019) review the influence of various methodological factors at play in MRS studies of MS, from study design to metabolite estimation. More specifically, studies using MRS in the CSC in MS are briefly discussed by Basha et al (2018) and further reviewed by Chen et al (2020) ; overall, reduced levels of N -acetyl aspartate and increased myo-inositol can be found in pwMS, are generally correlated with EDSS but not with cross-sectional area (CSA). The particular obstacles to SC MRS include the necessity for adequate B 0 shimming, and the inherent low spatial resolution of the method preventing tissue type-specific measurement, which will need to be addressed before its clinical potential can be exploited.…”

Section: Advanced Imaging Methodsmentioning

confidence: 99%

Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions

Combes

Clarke

O’Grady

et al. 2022

NeuroImage: Clinical

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“…A significant correlation was found between tNAA/cr and EDSS score, but no correlation between tNAA/cr and CSA was observed. MRS is a valuable tool and can provide important information about MS progression, even before the actual appearance of the MS lesions and may guide treatment decisions [ 89 ]. Given this capacity, MRS is a very promising imaging modality and its use may increase in the near future.…”

Section: Spinal Cord Mri In Multiple Sclerosismentioning

confidence: 99%

Imaging of the Spinal Cord in Multiple Sclerosis: Past, Present, Future

2020

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Spinal cord imaging in multiple sclerosis (MS) plays a significant role in diagnosing and tracking disease progression. The spinal cord is one of four key areas of the central nervous system where documenting the dissemination in space in the McDonald criteria for diagnosing MS. Spinal cord lesion load and the severity of cord atrophy are believed to be more relevant to disability than white matter lesions in the brain in different phenotypes of MS. Axonal loss contributes to spinal cord atrophy in MS and its degree correlates with disease severity and prognosis. Therefore, measures of axonal loss are often reliable biomarkers for monitoring disease progression. With recent technical advances, more and more qualitative and quantitative MRI techniques have been investigated in an attempt to provide objective and reliable diagnostic and monitoring biomarkers in MS. In this article, we discuss the role of spinal cord imaging in the diagnosis and prognosis of MS and, additionally, we review various techniques that may improve our understanding of the disease.

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Does MR spectroscopy of normal-appearing cervical spinal cord in patients with multiple sclerosis have diagnostic value in assessing disease progression? A prospective comparative analysis

Cited by 5 publications

References 40 publications

Multiparametric magnetic resonance imaging for detection of pathological changes in the central nervous system of a mouse model of multiple sclerosis in vivo

Multiparametric magnetic resonance imaging for detection of pathological changes in the central nervous system of a mouse model of multiple sclerosis in vivo

Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions

Imaging of the Spinal Cord in Multiple Sclerosis: Past, Present, Future

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