Does Modic Change Progresss With Age?

Tarukado, Kiyoshi; Ono, Teruaki; Tono, Osamu; Tanaka, Hiroki; Ikuta, Kentaro; Harimaya, Katsumi; Doi, Takehiko

doi:10.1097/brs.0000000000002254

Cited by 15 publications

(16 citation statements)

References 20 publications

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“…We detected Modic changes in 4.2% of patients and there was no gender predilection. Tarukado et al conducted a cross-sectional study regarding the prevalence of Modic changes in patients between the first and eighth decades of life [30]. They reported no patients with Modic changes at 10 years.…”

Section: Discussionmentioning

confidence: 99%

Lumbar intervertebral disc degeneration, end-plates and paraspinal muscle changes in children and adolescents with low-back pain

Ekşi

Özcan-Ekşi

Özmen

et al. 2020

Journal of Pediatric Orthopaedics B

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The prevalence of low-back pain (LBP) in adolescents ranges from 7 to 72%. We aimed to define the radiologic characteristics of the lumbar spine in children and adolescents with LBP with/without leg pain. Two hundred and fourteen children and adolescents, who were born between 2001 and 2009 and had lumbar spine MRI for LBP with/without leg pain, were evaluated in terms of intervertebral disc degeneration (IVDD), end-plates and paraspinal muscle changes on lumbar spine MRIs. Severe IVDD was detected at all lumbar levels except for L2-L3. Modic changes were present in 4.2% of the patients. Modic changes were more common in patients with severe IVDD than in those with mild-to-moderate IVDD.Severe IVDD was significantly associated with Modic changes at the corresponding L1-L2 and L3-L4 disc levels. Girls had significantly more fatty infiltration in the paraspinal muscles when compared to boys. The risk of having severe IVDD concomitant with Modic changes was high [odds ratio (OR), 8.6]. The OR was 20.7 for predicting the presence of severe IVDD at any level if Modic changes presented particularly at the L3-L4 level. The ORs of Modic changes presented at any lumbar level at the background of fat-infiltrated multifidus at L3-L4 and L4-L5 levels were 8.3 and 9.1, respectively. Fatty infiltration in the paraspinal muscles and IVDD were closely associated with Modic changes in children and adolescents with LBP. Lumbar IVDD in children and adolescents could be the result of a mechanical pathology.

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Section: Discussionmentioning

confidence: 99%

Lumbar intervertebral disc degeneration, end-plates and paraspinal muscle changes in children and adolescents with low-back pain

Ekşi

Özcan-Ekşi

Özmen

et al. 2020

Journal of Pediatric Orthopaedics B

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“…This study confirmed the role of vertebral BMF in lumbar disc degeneration and provides further evidence in the currently limited field. MRI quantitative and semi-quantitative studies have been conducted for patients with various ages with a primary focus on the variation of IVDD [29] or BMF [30], modic changes [31], and T2 and FF parameters studied separately with increasing age. To our knowledge, most studies have not reported the correlation of IVD T2 value and the Pfirrmann grading parameters with BMF in different ages.…”

Section: Discussionmentioning

confidence: 99%

Intervertebral disc degeneration associated with vertebral marrow fat, assessed using quantitative magnetic resonance imaging

Hong

Liu

et al. 2020

Skeletal Radiol

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Objective To investigate the potential clinical application of quantitative MRI in assessing the correlation between lumbar vertebrae bone marrow fat deposition and intervertebral disc degeneration. Materials and methods A total of 104 chronic lower-back pain volunteers underwent 3.0-T MRI with T2-weighted imaging, T2 mapping, and iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL-IQ) between August 2018 and June 2019. Each disc was assessed with T2 value by T2 mapping, and the L1-S1 vertebral bone marrow fat fraction was assessed by IDEAL-IQ. The differences and relationship between T2 value and the adjacent vertebral bone marrow fat fraction values within the five Pfirrmann groups, five age groups, and five lumbar levels were statistically analyzed. Results The vertebral bone marrow fat fraction had a significant negative correlation with T2 values of nucleus pulposus’ T2 values (p < 0.001). However, the significant negative correlation was only found between T2 values of nucleus pulposus and adjacent vertebral bone marrow fat in Pfirrmann II–III, L1/2-L5/S1 level, and 40–49 years’ age groups. Pfirrmann grades of the intervertebral disc were positively correlated with adjacent vertebrae bone marrow fat fraction (p < 0.05). Conclusion Lumbar bone marrow fat deposition significantly increases during the early stages of intervertebral disc degeneration. Quantitative measurements of bone marrow fat deposition and water content of intervertebral discs have a predictive value and are an important supplement to the qualitative traditional classification strategies for the early stages of intervertebral disc degeneration.

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“…Modic changes are found in asymptomatic individuals and are to some degree dependent on age. The evidence for the presence of Modic changes as an association to low back pain is conflicting (11,(209)(210)(211)(212)(213)(214). Two reviews have found Modic type 1 changes to be relatively correlated to low back pain (211,212).…”

Section: Discussionmentioning

confidence: 99%

Lumbar disc herniation surgery in adolescents and young adults

Lagerbäck

Möller

Gerdhem

2019

The Bone & Joint Journal

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AimsThe purpose of this study was to investigate the risk of additional surgery in the lumbar spine and to describe long-term changes in patient-reported outcomes after surgery for lumbar disc herniation in adolescents and young adults.Patients and MethodsWe conducted a retrospective study design on prospectively collected data from a national quality register. The 4537 patients were divided into two groups: adolescents (≤ 18 years old, n = 151) and young adults (19 to 39 years old, n = 4386). The risk of additional lumbar spine surgery was surveyed for a mean of 11.4 years (6.0 to 19.3) in all 4537 patients. Long-term patient-reported outcomes were available at a mean of 7.2 years (5.0 to 10.0) in up to 2716 patients and included satisfaction, global assessment for leg and back pain, Oswestry Disability Index, visual analogue scale for leg and back pain, EuroQol five-dimension questionnaire (EQ-5D), and 36-Item Short-Form Health Survey (SF-36) Mental Component Summary and Physical Component Summary scores. Statistical analyses were performed with Cox proportional hazard regression, chi-squared test, McNemar’s test, Welch–Satterthwaite t-test, and Wilcoxon’s signed-rank test.ResultsAny type of additional lumbar spine surgery was seen in 796 patients (18%). Surgery for lumbar disc herniation accounted for more than half of the additional surgeries. The risk of any additional surgery was 0.9 (95% confidence interval (CI) 0.6 to 1.4) and the risk of additional lumbar disc herniation surgery was 1.0 (0.6 to 1.7) in adolescents compared with the young adult group. Both age groups improved their patient-reported outcome data after surgery (all p < 0.001). Changes between short- (mean 1.9 years (1.0 to 2.0)) and long-term follow-up (mean 7.2 years (5.0 to 10.0)) were small.ConclusionThe risk of any additional lumbar spine surgery and additional lumbar disc herniation surgery was similar in adolescents and young adults. All patient-reported outcomes improved from preoperative to the short-term follow-up, while no likely clinically important differences between the short- and long-term follow-up were seen within both groups. Cite this article: Bone Joint J 2019;101-B:1534–1541

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Does Modic Change Progresss With Age?

Abstract: 4.

Cited by 15 publications

References 20 publications

Lumbar intervertebral disc degeneration, end-plates and paraspinal muscle changes in children and adolescents with low-back pain

Lumbar intervertebral disc degeneration, end-plates and paraspinal muscle changes in children and adolescents with low-back pain

Intervertebral disc degeneration associated with vertebral marrow fat, assessed using quantitative magnetic resonance imaging

Lumbar disc herniation surgery in adolescents and young adults

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