Does mobilisation and transmigration of mesenchymal stem cells occur after trauma?

Giannoudis, Peter V.; Goff, Troy; Roshdy, Tarek; Jones, Elena; McGonagle, Dennis

doi:10.1016/j.injury.2010.09.010

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…Of high significance in this field is the pioneering work of two groups who have studied progenitors isolated from human SFs and synovial membranes. Particularly interesting is the finding that the concentration of progenitors in OA SFs, particularly after injury, is about 20-fold higher than in RA, consistent with them being derived from injured joint structures rather than the bone marrow 126,127 . Indeed, single cell marker analysis supports the view that SF cells with multi-lineage potential are derived from the SY itself.…”

Section: The Phenotypic Plasticity Of Mesenchymal Progenitors In Oamentioning

confidence: 97%

The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

Plaas

Velasco

Gorski

et al. 2011

Osteoarthritis and Cartilage

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We conclude that progressive articular CA damage in post-injury OA results primarily from biomechanical, cell biologic and mediator changes that promote a fibroblastic phenotype in joint cells. Since ADAMTS5 and TGFβ1 appear to control this process, agents which interfere with their activities may not only enhance endogenous CA repair in vivo, but also improve the properties of tissue-engineered CA for implantation.

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Section: The Phenotypic Plasticity Of Mesenchymal Progenitors In Oamentioning

confidence: 97%

The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

Plaas

Velasco

Gorski

et al. 2011

Osteoarthritis and Cartilage

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“…It was reported that mesenchymal progenitor cells were present at the destruction site of the osteoarthritic cartilage and populated in the superficial layer of the articular cartilage [ 124 , 125 ]. They could also be isolated from the synovium and synovial fluids in OA joints [ 126 , 127 ]. Osteocytes regulate bone-marrow-derived cells through sclerostin, as altered sclerostin expression was found to affect adipogenesis and osteogenesis [ 79 ].…”

Section: Osteocyte Dysfunctionmentioning

confidence: 99%

Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis

Zhang

Wen

2021

IJMS

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Structural disturbances of the subchondral bone are a hallmark of osteoarthritis (OA), including sclerotic changes, cystic lesions, and osteophyte formation. Osteocytes act as mechanosensory units for the micro-cracks in response to mechanical loading. Once stimulated, osteocytes initiate the reparative process by recruiting bone-resorbing cells and bone-forming cells to maintain bone homeostasis. Osteocyte-expressed sclerostin is known as a negative regulator of bone formation through Wnt signaling and the RANKL pathway. In this review, we will summarize current understandings of osteocytes at the crossroad of allometry and mechanobiology to exploit the relationship between osteocyte morphology and function in the context of joint aging and osteoarthritis. We also aimed to summarize the osteocyte dysfunction and its link with structural and functional disturbances of the osteoarthritic subchondral bone at the molecular level. Compared with normal bones, the osteoarthritic subchondral bone is characterized by a higher bone volume fraction, a larger trabecular bone number in the load-bearing region, and an increase in thickness of pre-existing trabeculae. This may relate to the aberrant expressions of sclerostin, periostin, dentin matrix protein 1, matrix extracellular phosphoglycoprotein, insulin-like growth factor 1, and transforming growth factor-beta, among others. The number of osteocyte lacunae embedded in OA bone is also significantly higher, yet the volume of individual lacuna is relatively smaller, which could suggest abnormal metabolism in association with allometry. The remarkably lower percentage of sclerostin-positive osteocytes, together with clustering of Runx-2 positive pre-osteoblasts, may suggest altered regulation of osteoblast differentiation and osteoblast-osteocyte transformation affected by both signaling molecules and the extracellular matrix. Aberrant osteocyte morphology and function, along with anomalies in molecular signaling mechanisms, might explain in part, if not all, the pre-osteoblast clustering and the uncoupled bone remodeling in OA subchondral bone.

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“…In addition to their ability to differentiate into osteoblasts, chondroblasts, and adipocytes in vitro [7], MMSCs give rise to bone or cartilage after ectopic transplantation in vivo in animal models [3], as well as mediate the regeneration of bone tissue following injuries [11] and when genetic defects occur in osteogenesis (osteogenesis imperfecta) [19]. Moreover, many investigations have shown that MMSCs have the ability to differentiate into a variety of cells having mesodermal, ectodermal, and endodermal origins, including endothelial cells [20], cardiac myocytes [21], hepatocytes [22], and neural cells [23].…”

Section: Multipotency Of Mmscsmentioning

confidence: 99%

“…On the basis of these observations, a theory emerged, postulating that bone marrow is a deposit of both hematopoietic and mesenchymal stem cells. However, the suggestion that the renewal of connective tissues over the whole body depends on the activity of bone marrow-derived MSCs as yet remains unconfirmed [11]. …”

Section: Introductionmentioning

confidence: 99%

Mesenchymal Stem Cells in Tissue Growth and Repair

et al. 2011

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It has been established in the recent several decades that stem cells play a crucial role in tissue renewal and regeneration. Mesenchymal stem cells (MSCs) are part of the most important population of adult stem cells. These cells have hereby been identified for the very first time and subsequently isolated from bone marrow stroma. Bone marrow-derived MSCs have been believed to play the role of a source of cells for the renewal and repair of connective tissues, including bone, cartilage and adipose tissues. Cells similar to bone marrow-derived MSCs have now been identified in all postnatal tissues. Data on the distribution and function of MSCsin vivocollected using novel approaches pertaining to the identification of MSCsin situ, to their isolation from tissues, and finally to the determination of their biological properties have enabled successful revision of the role of MSCs in various organs and tissues. This review summarizes our own, as well as others’, data concerning the role of MSCs in the regulation processes of tissue repair and regeneration. In our opinion, MSCs provide the connection between the blood-vascular, immune, endocrine, and nervous systems and tissue-specific stem cells in the body.

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Does mobilisation and transmigration of mesenchymal stem cells occur after trauma?

Cited by 6 publications

References 38 publications

The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis

Mesenchymal Stem Cells in Tissue Growth and Repair

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