Does metronidazole reduce lipid peroxidation in burn injuries to promote healing?

Rao, C. Mallikarjuna; Ghosh, Arijit; Raghothama, Chaerkadi; Bairy, KL

doi:10.1016/s0305-4179(01)00126-7

Cited by 21 publications

(16 citation statements)

References 8 publications

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“…To prove that the risk of DCS is related to bacterial fermentation, it has to be demonstrated that MTZ does not itself affect the risk of DCS. Several studies have shown that taking oral MTZ could have beneficial effects, not only local effects on inflammatory bowel disease 19 but also systemic effects in subjects like burn victims 20 . This beneficial effect is not merely a result of MTZ’s antibiotic activity but also because of its antioxidant effect.…”

Section: Discussionmentioning

confidence: 99%

Colonic Fermentation Promotes Decompression sickness in Rats

Maistre

Vallée

Gempp

et al. 2016

Sci Rep

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Massive bubble formation after diving can lead to decompression sickness (DCS). During dives with hydrogen as a diluent for oxygen, decreasing the body’s H2 burden by inoculating hydrogen-metabolizing microbes into the gut reduces the risk of DCS. So we set out to investigate if colonic fermentation leading to endogenous hydrogen production promotes DCS in fasting rats. Four hours before an experimental dive, 93 fasting rats were force-fed, half of them with mannitol and the other half with water. Exhaled hydrogen was measured before and after force-feeding. Following the hyperbaric exposure, we looked for signs of DCS. A higher incidence of DCS was found in rats force-fed with mannitol than in those force-fed with water (80%, [95%CI 56, 94] versus 40%, [95%CI 19, 64], p < 0.01). In rats force-fed with mannitol, metronidazole pretreatment reduced the incidence of DCS (33%, [95%CI 15, 57], p = 0.005) at the same time as it inhibited colonic fermentation (14 ± 35 ppm versus 118 ± 90 ppm, p = 0.0001). Pre-diveingestion of mannitol increased the incidence of DCS in fasting rats when colonic fermentation peaked during the decompression phase. More generally, colonic fermentation in rats on a normal diet could promote DCS through endogenous hydrogen production.

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Section: Discussionmentioning

confidence: 99%

Colonic Fermentation Promotes Decompression sickness in Rats

Maistre

Vallée

Gempp

et al. 2016

Sci Rep

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“…Presumably, free radicals are formed which, in turn, react with cellular components resulting in death of the microorganism as also supported by some findings on the protective role of antioxidants against MTZ [49]. However, scavenging activities of MTZ on free oxygen radicals were reported [50–52]. It has been also suggested that the reactive species are intermediates in the reductive metabolism of MTZ, which leads to the formation of acetamide [53].…”

Section: Introductionmentioning

confidence: 86%

Genotoxicity Revaluation of Three Commercial Nitroheterocyclic Drugs: Nifurtimox, Benznidazole, and Metronidazole

Buschini

Ferrarini

Franzoni

et al. 2009

Journal of Parasitology Research

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Nitroheterocyclic compounds are widely used as therapeutic agents against a variety of protozoan and bacterial infections. However, the literature on these compounds, suspected of being carcinogens, is widely controversial. In this study, cytotoxic and genotoxic potential of three drugs, Nifurtimox (NFX), Benznidazole (BNZ), and Metronidazole (MTZ) was re-evaluated by different assays. Only NFX reduces survival rate in actively proliferating cells. The compounds are more active for base-pair substitution than frameshift induction in Salmonella; NFX and BNZ are more mutagenic than MTZ; they are widely dependent from nitroreduction whereas microsomal fraction S9 weakly affects the mutagenic potential. Comet assay detects BNZ- and NFX-induced DNA damage at doses in the range of therapeutically treated patient plasma concentration; BNZ seems to mainly act through ROS generation whereas a dose-dependent mechanism of DNA damaging is suggested for NFX. The lack of effects on mammalian cells for MTZ is confirmed also in MN assay whereas MN induction is observed for NFX and BNZ. The effects of MTZ, that shows comparatively low reduction potential, seem to be strictly dependent on anaerobic/hypoxic conditions. Both NFX and BNZ may not only lead to cellular damage of the infective agent but also interact with the DNA of mammalian cells.

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“…The MTZ dose was chosen based on literature data [ 9 , 11 , 15 ]. At the end of the experiment, 64 salivary glands, including 32 submandibular and 32 parotid (16 in each group), were collected from rats under anesthesia with ketamine (80 mg/kg) and xylazine (5 mg/kg).…”

Section: Methodsmentioning

confidence: 99%

Effect of Metronidazole on the Oxidoreductive Processes in the Submandibular and Parotid Glands in Experimental Research

Onopiuk

Dąbrowska

et al. 2018

Oxidative Medicine and Cellular Longevity

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Oxidative stress takes part in the pathomechanisms of many diseases, including oral disorders. The imbalance between oxidative and antioxidative processes may lead to periodontitis, osteitis, or oral cancers. Furthermore, many chemotherapeutics, e.g., metronidazole (MTZ), may also cause toxic reactions and affect oxidative reactions. The research focused on MTZ influence on oxidative destruction in the parotid and submandibular gland tissue in animal experimental model. Therefore, the concentrations of enzymatic and nonenzymatic markers of oxidative stress were measured in these two rat glands in the control and experimental MTZ-treated groups. The material for analysis included parotid and submandibular glands of male Wistar rats, which were treated with metronidazole for 7 days by gastric tube in a dose of 100 mg/kg b.w. On day 8, the material was obtained and frozen in temp. −80°C. Then, the following seven enzymatic and nonenzymatic parameters were measured: GPx, TOS, TAS, SOD, LPO, CAT, and GSH. The data were analysed using Statistica 10.0. Metronidazole treatment in the experimental model showed an increase in LPO, TOS, and TOS/TAS and a decrease in CAT, SOD, GPx, and TAS. The conclusions of this research were made. Metronidazole treatment in a dose of 100 mg/kg b.w. caused imbalance between oxidative and antioxidative reactions in the rat parotid and submandibular glands. An increase was observed in LPO, TOS, and TOS/TAS in both glands exposed to metronidazole. Decreased activity of CAT, SOD, GPx, and TAS was noted, which indicates attenuation of the gland antioxidative protective barrier.

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Does metronidazole reduce lipid peroxidation in burn injuries to promote healing?

Cited by 21 publications

References 8 publications

Colonic Fermentation Promotes Decompression sickness in Rats

Colonic Fermentation Promotes Decompression sickness in Rats

Genotoxicity Revaluation of Three Commercial Nitroheterocyclic Drugs: Nifurtimox, Benznidazole, and Metronidazole

Effect of Metronidazole on the Oxidoreductive Processes in the Submandibular and Parotid Glands in Experimental Research

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