Does measuring early basal serum follicular lutinising hormone assist in predicting In vitro fertilization (IVF)/Intracytoplasmic sperm injection (ICSI) outcome?

Kassab, Ahmed; Sabatini, Luca; Lieberman, Gidon; Zosmer, Ariel; Davis, Colin J.; Al-Shawaf, Talha

doi:10.1186/1477-7827-5-32

Cited by 6 publications

(6 citation statements)

References 28 publications

(30 reference statements)

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“…The observed lack of association between low baseline LH levels and poor IVF outcome is in agreement with studies consisting of patients undergoing either the long GnRH agonist suppressive (6)(7)11) or the GnRH antagonist (8) COH protocol.…”

supporting

confidence: 83%

Does day 3 luteinizing-hormone level predict IVF success in patients undergoing controlled ovarian stimulation with GnRH analogues?

Orvieto

Meltzer

Rabinson

et al. 2008

Fertility and Sterility

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supporting

confidence: 83%

Does day 3 luteinizing-hormone level predict IVF success in patients undergoing controlled ovarian stimulation with GnRH analogues?

Orvieto

Meltzer

Rabinson

et al. 2008

Fertility and Sterility

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“…22 The basal serum LH does not predict IVF/ICSI clinical pregnancy in routine fertility and endocrinological conditions. 23 In this study it is observed that effect of ovarian aging on FORT is negligible as compared to PFC, basal E2 and FSH levels and antral follicles continue to respond to FSH irrespective of ovarian aging which is supported by other studies. 11,24 The present study reflected that high peak E2 (at the time of OI) is associated with greater number of oocytes maturity, retrieval, fertilization, cleavage and the number of top quality embryos which enhance chances of clinical pregnancy as observed in other studies 14,25 The suggested high peak E2 for improvement of oocyte and embryo quality was observed in high FORT group of our study, similar results were shown in another study.…”

Section: Discussionsupporting

confidence: 84%

Importance of estimation of Follicular output rate (FORT) in females assisted by intracytoplasmic sperm injection

Rehman

Mustafa

Hoor

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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Background: We aimed to estimate pregnancy outcome after ICSI in terms of oocyte parameters, embryo quality, endometrial thickness, hormone and cytokine levels in women stratified on the basis of follicular output rate (FORT). Methods: Quasi experimental design was carried out after approval from "Ethical review board of Islamabad clinic serving infertile couples" from July 2010 to August 2013. One thousand and fifty females were selected with the criteria of age between 21-40 years, infertility of more than 2 years, body mass index of 18-35 kg/m 2 , menstrual cycle of 25 ± 7 days, both ovaries present with normal uterine cavity, serum FSH levels less than 8 IU/ml and normal thyroid-stimulating hormone levels. Females on short agonist or antagonist protocol with diagnosis of polycystic ovarian syndrome, fibroids or in their male partner sperms retrieved by testicular biopsy were excluded from the study. Down regulation of ovaries was followed by controlled ovarian stimulation, Ovulation Induction (OI), oocyte pick up, in vitro fertilization, Embryo Transfer (ET) and confirmation of pregnancy was done by serum beta hCG of more than 25 mIU/ml and cardiac activity on trans vaginal scan. Enzyme linked immuno sorbent assay was used for peak and mid luteal estradiol (E2), progesterone (P) and interleukin I-β estimation on OI and ET days respectively. FORT (ratio of preovulatory follicle count to antral follicle count × 100 on OI day) stratified females into low under the 33 rd percentile, medium between the 33 rd and the 67 th percentile and high above the 67 th percentile. Characteristics of groups were compared by one way analysis of variance. Results: Females 276 (33%), 288 (34%) and 282 (33%) comprised of low, medium and high FORT groups respectively. The number of retrieved, mature and fertilized oocytes, cleaved embryos, endometrial thickness and number of gestational sacs in the high FORT group was significantly high (P <0.001). High peak and midluteal E2 (P = 0.0025, 0.0001), low P (P = 0.0001) and high peak interleukin-1β (P = 0.0001) was observed in high FORT in comparison with medium FORT with resultant greater number of clinical pregnancies 183 (65%). Conclusions: The FORT in non PCOS patients may reflect good reproductive outcome after ICSI with maximum clinical pregnancies in high FORT group.

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“…Potential low responders were identified from either or both of the following criteria: [1] previous low ovarian response (defined by <3 oocytes retrieved) with DR and/or [2] women who required more than 300 IU/d starting dose of gonadotropin, based on the multivariate prediction model comprising of woman's age, basal serum FSH level, and body mass index (BMI) (22)(23)(24).…”

mentioning

confidence: 99%

Controlled ovarian hyperstimulation for low responders in in vitro fertilization/intracytoplasmic sperm injection: a low-dose flare protocol

Datta

Vitthala

Zosmer

et al. 2011

Fertility and Sterility

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Does measuring early basal serum follicular lutinising hormone assist in predicting In vitro fertilization (IVF)/Intracytoplasmic sperm injection (ICSI) outcome?

Abstract: Early follicular serum LH measurements in the 6 months before IVF/ICSI treatment cycle did not correlate with the clinical pregnancy or the live birth rate.

Cited by 6 publications

References 28 publications

Does day 3 luteinizing-hormone level predict IVF success in patients undergoing controlled ovarian stimulation with GnRH analogues?

Does day 3 luteinizing-hormone level predict IVF success in patients undergoing controlled ovarian stimulation with GnRH analogues?

Importance of estimation of Follicular output rate (FORT) in females assisted by intracytoplasmic sperm injection

Controlled ovarian hyperstimulation for low responders in in vitro fertilization/intracytoplasmic sperm injection: a low-dose flare protocol

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