Does mean platelet volume really increase in sudden sensorial hearing loss?

Bláha, M.; Košťál, Milan; Dršata, J; Chrobok, Viktor; Lánska, M.; Žák, Pavel

doi:10.1007/s00405-014-3384-9

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…Finally, 18 case–control studies were included [ 7–24 ], 12 studies mentioned MPV [ 7–14 , 16–18 , 24 ], 5 studies detected PDW [ 7 , 8 , 12 , 16 , 17 ], and 16 studies reported PLT level [ 7–10 , 12 , 13 , 15–24 ]. And 11 studies were performed in Turkey [ 7 , 8 , 10–13 , 15 , 17–19 , 23 ], 3 in China [ 20 , 21 , 24 ], 2 in Korea [ 9 , 23 ], 1 in the Czech Republic [ 14 ], and 1 in Iran [ 16 ]. Details about NOS assessment and PRISMA are in Supplementary S1 and Supplementary S2.…”

Section: Resultsmentioning

confidence: 99%

Relationship between platelet parameters and sudden sensorineural hearing loss: a systematic review and meta-analysis

Chen

et al. 2018

Bioscience Reports

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Recent years, the discussion about whether platelets participant in the development of sudden sensorineural hearing loss (SSHL) continues and many studies on the relationship between them have come to our attention. Some studies believe that platelet parameters have significantly changed in patients with SSHL, while some not, controversially. Therefore, to investigate the association between platelet parameters, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PLT), and SSHL, expecting to resolve controversy and provide clinical evidence for diagnosis and monitoring of SSHL. Basic methods: Literature was retrieved searching electronic databases (PubMed, Embase, Cochrane, and Scopus) and searching references of related articles by hand. A total of 18 case–control studies involving 1837/1734 subjects (SSHL/control) were included. Meta-analysis showed there was no difference between the patients who suffered SSHL and healthy controls in MPV level [standard mean difference (SMD) (95% confidence interval (CI)) = 0.16 (−0.07, 0.40), I2 = 80%, P<0.00001] and PLT [SMD (95% CI) = −0.03(−0.18, 0.12), I2 = 73%, P<0.00001]. While PDW exhibited significant difference [SMD (95% CI) = 0.85 (0.20, 1.49), I2 = 93%, P<0.00001]. Subgroup analysis about geographical area suggested PLT have obvious evidence for SSHL in Eastern country [SMD (95% CI) = 0.23 (0.14, 0.33), I2 = 0%, P=0.81]. Our study did not support a correlation between MPV and SSHL, while PLT may have clinical significance for SSHL in Eastern country. With insufficient data to explore the resource of heterogeneity for PDW, there is no decisive conclusion reached.

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Section: Resultsmentioning

confidence: 99%

Relationship between platelet parameters and sudden sensorineural hearing loss: a systematic review and meta-analysis

Chen

et al. 2018

Bioscience Reports

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“…and Bláha et al . found no correlation between mean platelet volume and sudden sensorineural hearing loss 31 , 32 . These papers have been discussed at length; the debate is ongoing, and there are advocates of both viewpoints.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of mean platelet volume on tinnitus

et al. 2015

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“…Also, studies reporting the increased frequencies of SSNHL in pathological conditions including sickle cell anemia, macroglobulinemia, Burger, cardiovascular and connective tissue diseases exist in the literature [5,6]. Neutrophil, lymphocyte and platelet values derived from routine hemogram analyses and their proportions were determined as prognostic and predictive indicators in several studies without any widely accepted precise parameters [8][9][10][11][12][13][14][15]. In SSNHL, tinnitus, dizziness, nausea and vomiting, aural fullness and findings of the upper airway infection can also be seen along with the hearing loss [4,16].…”

Section: Introductionmentioning

confidence: 99%

“…The platelets with bigger sizes are more active and prone to aggregate [12,17]. A number of studies reported a correlation between MPV values and cardiovascular diseases, stroke, thrombosis and inflammation [10,13,17]. Platelet distribution width (PDW), platelet count (PC) and plateletcrit (PCT) also constitute other important parameters.…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, we aimed to evaluate the association between SSNHL in diabetic and nondiabetic patients, and MPV, PDW, PC and PCT values with the determination of predictive and prognostic values of these parameters. Platelet values were reported in different studies with contradictory results in the literature [9][10][11][12][13][14][15]. However, studies concerning their prognostic value are still limited with the absence of a study focused on platelet values and DM.…”

Section: Introductionmentioning

confidence: 99%

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The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss

et al. 2020

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BackgroundWe aimed to evaluate the association between mean platelet volume, platelet distribution width (PDW), platelet count (PC) and plateletcrit (PCT), and the presence of sudden sensorineural hearing loss (SSNHL) and treatment response. In the literature, there is no study that investigates the platelet functions in diabetic patients with SSNHL.MethodsThe patients were retrospectively assigned into Group 1 (68 diabetic patients with SSNHL), Group 2 (63 nondiabetic patients with SSNHL) and Group 3 (64 healthy controls).ResultsPC was not significantly different between the groups (p > 0.05). MPV, PDW and PCT values were significantly higher in Group 1 as compared to Groups 2 and 3 (p < 0.05). Platelet parameters were not significantly different between the patients who were responsive and nonresponsive to the treatment. Therefore, the platelet parameters did not affect prognosis significantly in this study samples (p > 0.05).ConclusionsThis study showed that platelet parameters did not have a significant effect as a prognostic and predictive value in diabetic and nondiabetic patients with SSNHL. Further studies with more homogenous and larger study groups investigating the platelet parameters are needed to demonstrate microvascular damage and vascular alterations induced by diabetes mellitus.

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Does mean platelet volume really increase in sudden sensorial hearing loss?

Cited by 10 publications

References 22 publications

Relationship between platelet parameters and sudden sensorineural hearing loss: a systematic review and meta-analysis

Relationship between platelet parameters and sudden sensorineural hearing loss: a systematic review and meta-analysis

Prognostic value of mean platelet volume on tinnitus

The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss

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