Does maternal exposure during pregnancy to higher ambient temperature increase the risk of hypospadias?

Kılınç, Muhammet Fatih; Çakmak, Sedat; Demir, Demirhan Orsan; Doluoğlu, Ömer Gökhan; Yıldız, Yıldıray; Horasanlı, Kaya; Dalkılıç, Ayhan

doi:10.1016/j.jpurol.2016.06.015

Cited by 15 publications

(16 citation statements)

References 21 publications

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“…One paper covered multiple outcomes covering six organ systems [33]. Eleven studies reported measuring heat exposure in the first trimester, one of which extended to 14 weeks gestation [29].…”

Section: Resultsmentioning

confidence: 99%

“…The search in the mapping review identified 14,880 articles after removal of duplicate records ( Figure 1 ). Overall, 2273 articles were classified as “heat-exposure studies or heat adaptation studies”, and 175 of these were selected for full text screening, with 13 eligible for this review [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. A meta-analysis was not conducted due to considerable methodological diversity, statistical heterogeneity and the limited number of studies on each congenital defect.…”

Section: Resultsmentioning

confidence: 99%

“…The studies were published between 1991 and 2018 and covered births that took place in the period 1982 to 2015. In total, six studies reported on cardiac defects [ 22 , 25 , 28 , 30 , 32 , 33 ], three on neural tube defects [ 24 , 31 , 33 ], two on orofacial cleft or cranial defects [ 33 , 34 ], two on hypothyroidism [ 23 , 27 ], and one each on ocular anomalies [ 33 ], renal anomaly [ 33 ], hypospadias [ 29 ], musculoskeletal defects [ 33 ] and any lethal anomaly [ 26 ]. One paper covered multiple outcomes covering six organ systems [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

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Impacts of High Environmental Temperatures on Congenital Anomalies: A Systematic Review

Haghighi

Wright

Ayer

et al. 2021

IJERPH

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Links between heat exposure and congenital anomalies have not been explored in detail despite animal data and other strands of evidence that indicate such links are likely. We reviewed articles on heat and congenital anomalies from PubMed and Web of Science, screening 14,880 titles and abstracts in duplicate for articles on environmental heat exposure during pregnancy and congenital anomalies. Thirteen studies were included. Most studies were in North America (8) or the Middle East (3). Methodological diversity was considerable, including in temperature measurement, gestational windows of exposure, and range of defects studied. Associations were detected between heat exposure and congenital cardiac anomalies in three of six studies, with point estimates highest for atrial septal defects. Two studies with null findings used self-reported temperature exposures. Hypospadias, congenital cataracts, renal agenesis/hypoplasia, spina bifida, and craniofacial defects were also linked with heat exposure. Effects generally increased with duration and intensity of heat exposure. However, some neural tube defects, gastroschisis, anopthalmia/microphthalmia and congenital hypothyroidism were less frequent at higher temperatures. While findings are heterogenous, the evidence raises important concerns about heat exposure and birth defects. Some heterogeneity may be explained by biases in reproductive epidemiology. Pooled analyses of heat impacts using registers of congenital anomalies are a high priority.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Impacts of High Environmental Temperatures on Congenital Anomalies: A Systematic Review

Haghighi

Wright

Ayer

et al. 2021

IJERPH

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“…Nonetheless, exposure to heat in early pregnancy may also result in increased risk of developing other deformities for instance hypospadias [10]. Consequently, postnatal examination of children exposed to heat during early development stages should be thorough and detailed.…”

Section: Discussionmentioning

confidence: 99%

Women’s knowledge on activities associated with maternal hyperthermia during pregnancy. A cross-sectional study of the sample of Polish women

Szatko

Boryszewska

Mabiala

et al. 2017

Polish Journal of Public Health

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Introduction. Hyperthermia during the first trimester increases the risk of miscarriage and birth defects. A variety of activities predisposing to hyperthermia during pregnancy such as attending sauna, hot tubs or solarium may lead to irreversible abnormalities of the developing fetus.Aim. The aim of the study was to assess women's knowledge on the risks of maternal hyperthermia during each trimester of pregnancy.Material and methods. It was a cross-sectional study conducted by means of an anonymous questionnaire. The study group included 302 women aged 17-65 who were admitted to a tertiary referral hospital. The questionnaire was designed on the basis of the Committee Opinion formulated by the American College of Obstetricians and Gynecologists and was consisted of two sections: demographic data and respondents' opinions on activities associated with hyperthermia in pregnancy. Statistical analysis was conducted to estimate the association of age, level of education and obstetrical status.Results. The lowest percentage of given proper answers was observed in case of questions about early pregnancy. There was no association between respondents' level of education and choice of correct answers. Current pregnancy was associated with higher awareness of contraindicated using of hot tubs and steam rooms.Conclusions. Patients' education concerning hyperthermia in pregnancy should focus on information about high risk of birth defects caused by overheating in the early pregnancy and a variety of activities linked with temperature elevation.

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“…However, evidence on the impact of such an exposure on congenital anomalies has remained very scarce. A limited number of studies have reported an increased risk of congenital heart disease, 6 7 congenital cataract 8 and hypospadias 7 associated with maternal exposure to enhanced ambient temperature. In this context, the study by Auger et al 9 is a notable step forward in our understanding of the potential implications of current changes in climate on congenital anomalies.…”

mentioning

confidence: 99%

Congenital anomalies: an under-evaluated risk of climate change

Dadvand

2017

Occup Environ Med

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Does maternal exposure during pregnancy to higher ambient temperature increase the risk of hypospadias?

Cited by 15 publications

References 21 publications

Impacts of High Environmental Temperatures on Congenital Anomalies: A Systematic Review

Impacts of High Environmental Temperatures on Congenital Anomalies: A Systematic Review

Women’s knowledge on activities associated with maternal hyperthermia during pregnancy. A cross-sectional study of the sample of Polish women

Congenital anomalies: an under-evaluated risk of climate change

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