Does Lymphovascular Invasion Predict Regional Nodal Failure in Breast Cancer Patients With Zero to Three Positive Lymph Nodes Treated With Conserving Surgery and Radiotherapy? Implications for Regional Radiation

Boutrus, Rimoun; Abi‐Raad, Rita; Niemierko, Andrzej; Brachtel, Elena F.; Rizk, L.; Kelada, A.; Taghian, Alphonse G.

doi:10.1016/j.ijrobp.2009.08.049

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…LVI has also been associated with BCSS and LRR [ 60 – 62 ]. Lee et al [ 61 ] analysed 2,760 node negative breast cancer patients in order to evaluate BCSS.…”

Section: Discussionmentioning

confidence: 99%

“…In the context of LRR, Truong et al [ 40 ] observed on 763 T1–2N0 patients, at a median follow up of 7 years, that LVI was an independent prognostic factor for LRR (RR 2.32; 95% CI 1.26–4.27, p < 0.007). In the same way, Boutrus et al [ 62 ] studied 1.275 N0 women (692 premenopausal and 583 postmenopausal) who underwent mastectomy followed by systemic therapy. They identified LVI ( p = 0.23) and tumour size> 2 cm ( p = 0.027) as RFs for LRR in premenopausal women, while LVI was the only significant factor associated with loco-regional failure in postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

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Clinical decision making in postmastectomy radiotherapy in node negative breast cancer

Barrientos

Samtani

Frelinghuysen

et al. 2018

ecancer

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For decades, postmastectomy radiotherapy (PMRT) has been recommended for node positive [N(+)] breast cancer patients; nevertheless, the beneficial effect of PMRT for treatment of node negative [N(−)] disease remains under discussion. Nowadays, the biology of breast cancer and the risk factors (RFs) for locoregional failure (LRF) must be included in the decision on whether or not to carry out PMRT. For these reasons, the present review aims to evaluate the rationale use of PMRT in N(−) patients and discuss which subgroups may further benefit from the treatment in present times where the decision must be personalised, according to the RFs of locoregional recurrence (LRR). To perform the analysis, we ponder that LRR of over 10% should be considered unacceptable due to the fact that LRRs generate great morbidity in patients. For this purpose, we consider that routine RT in these patients is not recommended, although there are subgroups of patients with high LRR, in which PMRT could be beneficial.

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“…LVI has also been associated with BCSS and LRR [ 60 – 62 ]. Lee et al [ 61 ] analysed 2,760 node negative breast cancer patients in order to evaluate BCSS.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical decision making in postmastectomy radiotherapy in node negative breast cancer

Barrientos

Samtani

Frelinghuysen

et al. 2018

ecancer

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show abstract

“…Activation of these genes leads to the production of cytokines that are able to alter the microenvironment surrounding tumor cells, which in turn increases the invasion and metastasis of surviving tumor cells (2,3). Previous studies have demonstrated that radiation promotes the invasion or metastasis of various types of cancer cells, including pancreatic, glioma, hepatocellular, breast and melanoma (4)(5)(6)(7). In addition, a clinical study revealed that invasive recurrence increased following treatment of ductal carcinoma in situ with radiation therapy (8).…”

Section: Introductionmentioning

confidence: 99%

Radiation enhances the invasion abilities of pulmonary adenocarcinoma cells via STAT3

Li¹,

Gao

Jiang³

et al. 2013

Molecular Medicine Reports

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In the present study, the effect of radiation on the invasion of the pulmonary adenocarcinoma cell line, A549, was investigated. Invasion of A549 cells irradiated with 2 and 4 Gy doses of γ‑ray was detected using the transwell Matrigel invasion assay. Levels of matrix metalloproteinase 2 (MMP‑2) and phosphorylated signal transducer and activator of transcription 3 (STAT3) were detected by reverse transcription PCR (RT-PCR) and/or immunoblotting. The enzyme activity of MMP‑2 was examined by gelatin zymography. Results demonstrated that the invasion of A549 cells was significantly enhanced by γ‑ray radiation at doses of 2 or 4 Gy. In addition, exposure to radiation was found to promote transcriptional expression of MMP‑2 and increase MMP‑2 enzyme activity. Irradiation activated the phosphorylation of STAT3 and promoted the nuclear localization of STAT3. The blockage of STAT3 phosphorylation using a specific inhibitor (AG490) suppressed the irradiation‑induced elevation of MMP‑2 expression, enzyme activity and invasion of A549 cells. Finally, the expression of vascular endothelial growth factor (VEGF) was found to be upregulated by radiation, which was associated with the activation of STAT3. Results of the current study indicate that irradiation leads to activation of STAT3 and translocation to the nucleus, leading to activation of VEGF and MMP‑2 transcription, resulting in the increased invasion of A549 cells.

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Outcome after conservative surgery and breast irradiation in 5,717 patients with breast cancer: implications for supraclavicular nodal irradiation

Recht¹

2010

Breast Diseases: A Year Book Quarterly

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Does Lymphovascular Invasion Predict Regional Nodal Failure in Breast Cancer Patients With Zero to Three Positive Lymph Nodes Treated With Conserving Surgery and Radiotherapy? Implications for Regional Radiation

Cited by 9 publications

References 23 publications

Clinical decision making in postmastectomy radiotherapy in node negative breast cancer

Clinical decision making in postmastectomy radiotherapy in node negative breast cancer

Radiation enhances the invasion abilities of pulmonary adenocarcinoma cells via STAT3

Outcome after conservative surgery and breast irradiation in 5,717 patients with breast cancer: implications for supraclavicular nodal irradiation

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