Does &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection Play a Role in Susceptibility to Brucellosis?

Afrasiabian, Shahla; Mohsenpour, Behzad; Ghaderi, Ebrahim; Nadri, Sara; Hajibagheri, Katayon

doi:10.7883/yoken.jjid.2017.043

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…In recent years, there has been growing interest in the relationship between H. pylori and extragastric diseases. Research has shown that H. pylori was closely associated with infectious diseases caused by pathogens such as HIV, HCV, and brucella ( Furusyo et al, 2011 ; Afrasiabian et al, 2017 ; Guo et al, 2021 ). Additionally, H. pylori may have a protective role against tuberculosis, allergic diseases, asthma, shigellosis, and other diarrheal diseases ( Blaser et al, 2008 ; Perry et al, 2010 ; Cohen et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

CagA-positive Helicobacter pylori may promote and aggravate scrub typhus

Du,

Zeng,

Pang

et al. 2024

Front. Microbiol.

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Helicobacter pylori (H. pylori) infection may alter the host’s resistance to tsutsugamushi disease pathogens through the Th1 immune response, leading to potential synergistic pathogenic effects. A total of 117 scrub typhus cases at Beihai People’s Hospital and affiliated hospitals of Youjiang University for Nationalities and Medical Sciences were studied from January to December 2022, alongside 130 healthy individuals forming the control group. All participants underwent serum H. pylori antibody testing. The prevalence of H. pylori infection was significantly higher among scrub typhus patients (89.7%) compared to healthy individuals (54.6%) (p < 0.05). Moreover, type I H. pylori infection was notably more prevalent in scrub typhus cases (67.5%) compared to healthy individuals (30%) (p < 0.05). Multifactorial analysis demonstrated type I H. pylori infection as an independent risk factor for scrub typhus (adjusted odds ratio: 2.407, 95% confidence interval: 1.249–4.64, p = 0.009). Among scrub typhus patients with multiple organ damage, the prevalence of type I H. pylori infection was significantly higher (50.6%) than type II H. pylori infection (15.4%) (χ2 = 4.735, p = 0.030). These results highlight a higher incidence of H. pylori infection in scrub typhus patients compared to the healthy population. Additionally, type I H. pylori strain emerged as an independent risk factor for scrub typhus development. Moreover, individuals infected with type I H. pylori are more susceptible to multiple organ damage. These findings suggest a potential role of H. pylori carrying the CagA gene in promoting and exacerbating scrub typhus.

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