Does liraglutide alleviate inflammation in brain-dead donors? A randomized clinical trial
Geisiane Custódio,
Andrew Maykon Massutti,
Mauro Rafael da Igreja
et al.
Abstract:Brain death triggers an inflammatory cascade that damages organs before procurement, adversely affecting the quality of grafts. This randomized clinical trial aimed to compare the efficacy of liraglutide compared to placebo in attenuating brain death-induced inflammation, endoplasmic reticulum stress, and oxidative stress. We conducted a double-blinded, placebo-controlled, randomized clinical trial with brain-dead donors. Fifty brain-dead donors were randomized to receive subcutaneous liraglutide or placebo. T… Show more
“…Building on this, Custódio et al 5 work to gather some clinical insights, at the same time prompting a wider discussion on the importance and the implications of deceased donor intervention research (DDIR)—an area whose potential and challenges are yet to be fully realized. Central to their investigation is glucagon-like peptide 1 (GLP-1), a gut-derived hormone synthesized by L-cells primarily localized within terminal ileal and colonic mucosa and secreted as a neuroendocrine response to eating 6 .…”
“…Building on this, Custódio et al 5 work to gather some clinical insights, at the same time prompting a wider discussion on the importance and the implications of deceased donor intervention research (DDIR)—an area whose potential and challenges are yet to be fully realized. Central to their investigation is glucagon-like peptide 1 (GLP-1), a gut-derived hormone synthesized by L-cells primarily localized within terminal ileal and colonic mucosa and secreted as a neuroendocrine response to eating 6 .…”
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