Does laparoscopic surgery have a role in the treatment of gallbladder cancer?

Kim, Eung Kook; Lee, Sang Kuon; Kim, Won Woo

doi:10.1007/s005340200074

Cited by 31 publications

(19 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, in the included researches, Kim et al and Cavallaro et al respectively compared the 1-and 3-year survival rate after two kinds of surgery, which was all up to 100%. 14,16 Also, few patients suffered from post-operative tumor recurrence in these studies. Lee et al carried out a systematic review for T1 stage GBC, in included researches of which 67% and 30% patients with T1b GBC respectively accepted simple cholecystectomy and radical resection.…”

Section: Sensitivity Analysis and Bias Identifymentioning

confidence: 80%

“…Heterogeneity exists (χ2 = 11.54, P = 0.17, I2 = 31%), hence random model was used, and the result shows RR is obviously better than SC in increasing 1-year survival rate (OR=3.28, 95% CI: 1.83-5.89, P<0.0001). In addition, in the study of Kim et al, Cavallaro et al and Ke et al 14,16,19 1-year survival rate of stage II GBC were all 100%. Ten studies recorded 3-year survival rate.…”

Section: Survival Rate Analysismentioning

confidence: 90%

“…5,[11][12][13][14][15][16][17][18][19][20][21][22][23][24] All the studies were non-randomized control trials. Table 1 and 2 respectively show the character of included literatures and NOS quality assessment scale.…”

Section: Characteristics Of Included Literatures and Quality Assessmentmentioning

confidence: 99%

“…5,[11][12][13][14][16][17][18][19]21,23,24 Data of 1-year survival rate from nine studies can be pooled (Figure 2). Heterogeneity exists (χ2 = 11.54, P = 0.17, I2 = 31%), hence random model was used, and the result shows RR is obviously better than SC in increasing 1-year survival rate (OR=3.28, 95% CI: 1.83-5.89, P<0.0001).…”

Section: Survival Rate Analysismentioning

confidence: 99%

See 3 more Smart Citations

Simple cholecystectomy versus radical resection for stage Ⅱ gallbladder cancer: a meta-analysis

Cheng

Qiu

et al. 2017

Int Surg J

View full text Add to dashboard Cite

INTRODUCTIONGBC was first reported more than two hundred years ago, but the poor therapeutic effect for GBC patients is still frustrating now, the 5-year survival rate is no more than 5%, and the mean survival time is only about half a year. 1 It still relies on surgical method to treat and provide the possibilities of favorable prognosis, while auxiliary methods like radiotherapy and chemotherapy are likely to reduce the chance of tumor relapse and improve the longterm survival of GBC patients. 2 GBC patients' survival time -one of the major indicators for prognosis judgment isn't affected by sexuality, age or ABSTRACT Background: GBC was first reported more than two hundred years ago, but the poor therapeutic effect for GBC patients is still frustrating now, the 5-year survival rate is no more than 5%, and the mean survival time is only about half a year. The objective of this study was to evaluate the importance of radical resection in the treatment of Nevin II and T1b stage gallbladder cancer (stage II GBC) by analyzing the survival rate and tumor recurrence rate after accepting simple cholecystectomy (SC) and radical resection (RR). Methods: PubMed, Embase, Chinese National Knowledge Infrastructure and Wanfang databases was searched from inception to February 2016. Quality assessment was conducted in each of the available studies by using the validated Newcastle-Ottawa Quality Assessment Scale (NOS) for cohort and case-control studies. Publication bias was also assessed by using a funnel plot. The odds ratio (OR) and its 95% confidence interval (95% CI) were employed to estimated effect size. All statistical analyses were carried out using Rev Man 5.2 software. Results: A total of fifteen studies encompassing 424 patients meeting the search criteria were included. Pooled analyses revealed that comparing to simple cholecystectomy, radical resection can significantly increase the 1-, 3-and 5-year survival rate of patients with stage II GBC (OR = 3.28, 95% CI: 1.83-5.89, P<0.0001; OR = 2.52, 95% CI: 1. P = 0.0006; OR = 3.19, P<0.0001), and patients after radical resection have a significant lower tumor recurrence rate (OR = 0.30, 95% CI: 0.11-0.80, P = 0.02). Conclusions:The short-and long-term survival rate of patients with stage II GBC following radical resection is obviously higher than that of patients receiving simple cholecystectomy, and the tumor recurrence rate is obviously lower. Radical resection would be a better choice for stage II GBC.

show abstract

Section: Sensitivity Analysis and Bias Identifymentioning

confidence: 80%

Section: Survival Rate Analysismentioning

confidence: 90%

Section: Characteristics Of Included Literatures and Quality Assessmentmentioning

confidence: 99%

Section: Survival Rate Analysismentioning

confidence: 99%

See 2 more Smart Citations

Simple cholecystectomy versus radical resection for stage Ⅱ gallbladder cancer: a meta-analysis

Cheng

Qiu

et al. 2017

Int Surg J

View full text Add to dashboard Cite

show abstract

“…L-CHE is an effective treatment strategy in T1 GBC [28][29][30][31] if bile spillage and excessive manipulation of the gallbladder can be avoided [32]. Tumor cell dissemination may be due to an iatrogenic gall-bladder perforation during L-CHE, occurring in up to 15% by experienced surgeons [33].…”

Section: Operative Procedures In Gbcmentioning

confidence: 99%

Gallbladder cancer – only surgery is curative

Puhalla

Laengle

2006

Eur Surg

View full text Add to dashboard Cite

Zusammenfassung. Grundlagen: Das Gallenblasenkarzinom (GBC) ist ein seltenes Karzinom, welches eine höhere Inzidenz bei Frauen als bei Männern hat. Das GBC hat zumeist eine schlechte Prognose.Methodik: Es wird eine Übersicht über die Literatur und aktuelle therapeutische Konzepte gegeben. Ergebnisse: In der Karzinomentstehung scheint die chronische Entzündung und die Dysplasie eine größere Bedeutung zu haben als das Adenom. Der Ultraschall und das CT sind für die Evaluierung der lokalen Tumorextension sehr effektiv. Die Resektion ist die einzige kurative therapeutische Option beim GBC. Die Cholezystektomie ist die adä-quate Therapie für T1-GBC. Im Falle von T2-Tumoren ist eine Leberresektion im Bereich des Gallenblasenbettes mit zumindest 2 cm Abstand und eine Lymphadenektomie wie bei T3/T4 erforderlich. Bei T3-Tumoren sollte der Leberresektionsrand zumindest 3 cm sein, und bei T4-Tumoren ist eine zusätzliche Resektion der extrahepatischen Gallenwege erforderlich. Die konservativen onkologischen Optionen für das GBC werden kontroversiell diskutiert.Schlussfolgerungen: Eine frühe Tumordiagnose und eine radikale Resektion sind die einzigen Parameter, welche eine Heilung bei Patienten mit GBC ermöglichen, aber es ist nur bei einer geringen Patientenanzahl mög-lich.Schlüsselwörter: Gallenblasenkarzinom, Entstehung, therapeutische Möglichkeiten, Resektion, Überle-ben.Summary. Background: Gallbladder cancer (GBC) is a rare malignancy which has a higher incidence in female than in male patients. GBC has usually a poor prognosis.Methods: Review of literature and current therapeutic concepts.Results: In the carcinogenesis of GBC chronic inflammation and dysplasia seem to be more important than adenoma. For the evaluation of the local tumor extension ultrasound and CT scan are most effective. Resection offers the only curative therapeutic option in GBC. Cholecystectomy is the adequate therapy for T1 GBC. In case of T2 tumors liver resection of the gallbladder bed with a parenchymal edge of at least 2 cm and lymphadenectomy like in T3/T4 are required. For T3 tumors the edge of resected liver parenchyma should be at least 3 cm and for T4 tumors an additional extrahepatic bile duct resection is necessary. Conservative oncological therapeutic options for GBC are discussed controversially.Conclusions: Early tumor detection and radical resection are the only parameters to cure GBC but it is just possible in a small number of patients.

show abstract