Does land-based exercise-therapy improve physical activity in people with knee osteoarthritis? A systematic review with meta-analyses

Follow-up of individualised physical activity on prescription and individualised advice in patients with hip or knee osteoarthritis: A randomised controlled trial

“…3,4 According to systematic reviews with meta-analyses, the effects of physical activity interventions decline over time and sustained long-term effects are rare. 5,6 However, comprehensive interventions individualised to the patient may increase long-term physical activity. 7,8 In the Fit & Strong study, 7 participants with improved physical activity at 12 and 18 months had received education combined with aerobic walking and resistance training for 22 sessions and a total of 36 h. All participants also developed individualised plans for long-term maintenance of physical activity.…”

Association of baseline physical activity participation with participant characteristics and outcomes following education and exercise‐therapy in people with knee osteoarthritis: A GLA:D® Australia prospective cohort study

“…Exercise-therapy and patient education are recommended as first-line treatments for knee osteoarthritis according to guidelines (Gibbs et al, 2023) to reduce pain and improve knee function (Skou & Roos, 2017). Exercise-therapy focused on walking or mixed cardiovascular and resistance programs can increase physical activity in the short-term in people with knee osteoarthritis (Bell et al, 2022).…”

“…Exercise‐therapy and patient education are recommended as first‐line treatments for knee osteoarthritis according to guidelines (Gibbs et al., 2023) to reduce pain and improve knee function (Skou & Roos, 2017). Exercise‐therapy focused on walking or mixed cardiovascular and resistance programs can increase physical activity in the short‐term in people with knee osteoarthritis (Bell et al., 2022). Moderate increases in physical activity may also be facilitated when education and exercise‐therapy are combined in the medium‐term, when compared to non‐exercise interventions (Bell et al., 2022).…”

“…Exercise‐therapy focused on walking or mixed cardiovascular and resistance programs can increase physical activity in the short‐term in people with knee osteoarthritis (Bell et al., 2022). Moderate increases in physical activity may also be facilitated when education and exercise‐therapy are combined in the medium‐term, when compared to non‐exercise interventions (Bell et al., 2022). The Good Life with osteoArthritis from Denmark (GLA:D ® ) program (Roos et al., 2018) is one program developed to facilitate the implementation of education and exercise‐therapy for people with knee osteoarthritis, now adopted in at least nine countries (Crossley et al., 2021), and is associated with clinically meaningful improvements in knee‐related burden in people with knee osteoarthritis (Roos et al., 2021).…”

Modulation of the long non-coding RNA Mir155hg by high, but not moderate, hydrostatic pressure in cartilage precursor cells

“…Though the exact cause isn’t known, several risk factors have been identified such as age, intensive physical activity, obesity, joint trauma and genetic predisposition [ 3 ]. So far, no cure has been found, but physical loading of the joints through moderate physical exercise has been shown to slow the progression of the disease [ 4 , 5 ], suggesting that mechanical stimulation is essential to cartilage maintenance and health. In vivo, joint loading is believed to be sensed by chondrocytes partly in the form of hydrostatic pressure (HP) typically ranging from 3–10 MPa [ 6 ], and application of low or moderate HP in vitro has been used to promote cartilage differentiation in tissue engineered cartilage [ 7 , 8 ], counteract the effects of OA or interleukin-1β on human chondrocyte morphology [ 9 ], and stimulate chondrocyte differentiation [ 10 , 11 ].…”