Does iron-deficient erythropoiesis in pregnancy influence fetal iron supply?

Harthoorn-Lasthuizen, Else J.; Lindemans, Jan; Langenhuijsen, M. M. A. C.

doi:10.1034/j.1600-0412.2001.080005392.x

Cited by 39 publications

(19 citation statements)

References 29 publications

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“…The median age (interquartile range [IQR]) of pregnant women at their first ANC visit was 25 (21-30) years. At baseline, the median gestational age (IQR) was 23 (19)(20)(21)(22)(23)(24)(25)(26) weeks. The prevalence of ID among pregnant women at first and second ANC visits, and at delivery was 30.5%, 34.0%, and 28.4%, respectively ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Other studies among pregnant women have revealed similar findings of fetal impassivity (in reference to ferritin supply) to the ID status of the mother. 26,27 In our study population, after the first ANC, all pregnant women were given daily oral iron and folic acid supplementations in addition to the IPTp they were randomized to, in the MiPPAD clinical trial. Pregnant women who remained iron deficient at the second ANC visit and at delivery may have had very low iron stores before pregnancy and as a result remained deficient after fetal demands even 5 after supplementation or may not have taken the supplements, as the intake was not directly observed.…”

Section: Figurementioning

confidence: 99%

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Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function

et al. 2016

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To investigate the impact of prenatal maternal iron deficiency (ID) on cord blood serum ferritin (CBSF) concentration and infant cognitive and motor development. METHODS:Our prospective cohort study included 636 mother-singleton child pairs from 828 eligible pregnant women who were enrolled during their first antenatal care (ANC) visit in Allada, Benin, into a clinical trial comparing the efficacy of mefloquine and sulfadoxinepyrimethamine. Venous blood samples of women were assessed for ferritin and hemoglobin concentrations at the first and second ANC visits (occurring at least 1-month apart) and at delivery. Women were prescribed daily iron and folic acid supplements throughout pregnancy. Hematologic examinations were repeated for cord blood at birth. At age 1 year, cognitive and motor functions of children were assessed by using the Mullen Scales of Early Learning. RESULTS:The prevalence of prenatal ID at first and second ANC visits, and at delivery was 30.5%, 34.0%, and 28.4%, respectively. CBSF concentrations were similar between ID and non-ID pregnant women. Neither prenatal ID nor CBSF concentration was associated with poor cognitive or gross motor function of children at age 1 year. CBSF concentrations were lower among mothers who had ID anemia (IDA) at delivery compared with non-IDA pregnant women (adjusted mean difference: -0.2 [95% confidence interval: -0.4 to -0.0]). CONCLUSIONS:In a malaria-endemic region, ID in pregnancy in the context of iron supplementation is neither associated with CBSF concentration nor with infant cognitive and motor development. Prenatal IDA around the time of delivery is associated with lower CBSF concentrations.

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Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function

et al. 2016

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“…Despite this compensation in placental Fe transport to the fetus in the presence of maternal Fe deficiency, the infant's Fe accretion still appears to suffer. It was long believed that only severe IDA during pregnancy affects fetal Fe stores; in fact, some studies (Siimes & Siimes, 1986;Harthoorn-Lasthuizen et al 2001) have shown no differences in neonatal Fe status indices between infants born to Fe-deficient and Fe-replete mothers. However, recent studies with longer-term follow-up (Colomer et al 1990;Kilbride et al 1999;de Pee et al 2002) have shown that infants born to Fe-deficient anaemic mothers have a higher incidence of Fe deficiency and anaemia later in infancy than infants born to Fe-replete mothers.…”

Section: Fetal Iron Accretion and Erythropoiesismentioning

confidence: 99%

Session 4: Mineral metabolism and body composition Iron status of breast-fed infants

2007

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Fe deficiency is a common nutritional disorder during infancy, particularly in low-income countries. The Fe status of a breast-fed infant is strongly influenced by the body Fe content at birth, which is determined by factors that operate before birth (maternal Fe status before and during pregnancy; infant gestational age and birth weight) and at the time of delivery (the timing of umbilical cord clamping). Delaying the clamping of the umbilical cord for 2 min can increase body Fe content by approximately 33% (75 mg), and results in greater Fe stores at 6 months of age. After birth, male gender and a rapid rate of weight gain are associated with lower Fe status. During the first half of infancy dietary Fe requirements depend on Fe stores at birth. For an exclusively-breast-fed full-term normal-birth-weight infant with delayed umbilical cord clamping, whose mother had adequate Fe status during pregnancy, the Fe provided from stores and breast milk is sufficient for ≥6 months, but before this time higher-risk infants may become Fe deficient. Fe supplementation can be beneficial for high-risk infants, but can have adverse effects on growth and morbidity of Fe-replete infants. After 6 months most breast-fed infants will require complementary foods that are rich in Fe.

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“…t Women who do not take iron supplements frequently deplete their iron stores during the second and third trimesters of pregnancy and hemoglobin concentration is low than supplemented women. [14][15][16] The relationship between maternal and fetal iron transfer the fetus may depend 17-21 on or be independent [22][23][24][25][26] of maternal iron status.…”

Section: Introductionmentioning

confidence: 99%