Does intranasal oxytocin promote prosocial behavior to an excluded fellow player? A randomized-controlled trial with Cyberball

Riem, Madelon M E; Bakermans‐Kranenburg, Marian J.; Huffmeijer, Renske; IJzendoorn, M.H. van

doi:10.1016/j.psyneuen.2012.12.023

Cited by 94 publications

(93 citation statements)

References 53 publications

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“…For example, another study by (Bartz et al, 2011) showed that individuals with low scores on attachment anxiety reported more positive childhood memories after OT administration (compared to placebo), while in individuals with high scores on attachment anxiety the inverse effect was found, indicating more negative recollections on the caring behavior of their mothers after OT administration. Also positive effects of OT on one's willingness to donate money to charity (Riem et al, 2013) or prosocial behavior in a virtual ball-tossing game were shown to be lowered or absent in individuals with high reports of parental love-withdrawal. Together, these observations further highlight the importance of adequately characterizing inter-individual differences in attachment style and/or other personality traits for evaluating expectancies on OT treatment outcome.…”

Section: Discussionmentioning

confidence: 98%

“…Based on initial animal and human research, the physiological role of OT in lactation and childbirth is wellestablished (Galbally et al, 2011;Insel, 2010;Kendrick, 2000;Sue Carter, 1998). More recently, different lines of research have shown a strong involvement of OT in complex social behaviors including interpersonal bonding, maternal care, and the ability to establish trust and form social attachments (for reviews see Bakermans-Kranenburg and van IJzendoorn (2013), Bartz et al (2011), Guastella and MacLeod (2012), but also Nave et al (2015)). …”

Section: Introductionmentioning

confidence: 99%

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Long-term oxytocin administration enhances the experience of attachment

Bernaerts

Prinsen

Berra

et al. 2017

Psychoneuroendocrinology

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Oxytocin and attachment -Bernaerts et al. 2 Highlights We examined effects of multiple-dose intranasal oxytocin (OT) on attachment  State and Trait attachment were assessed before and after two-week OT administration  OT treatment decreased attachment avoidance and increased attachment toward peers  Participants with less secure peer attachment showed most pronounced OT effects  OT treatment was also associated with changes in mood ABSTRACTThe neuropeptide 'oxytocin' (OT) is known to play a pivotal role in a variety of complex social behaviors by promoting a prosocial attitude and interpersonal bonding. Previous studies showed that a single-dose of exogenously administered OT can affect trust and feelings of attachment insecurity. With the present study, we explored the effects of two weeks of daily OT administration on measures of state and trait attachment using a double-blind betweensubjects randomized placebo-controlled design. In 40 healthy young adult men state and trait attachment were assessed before and after two weeks of daily intranasal OT (24 IU) or placebo using the State Adult Attachment Scale and the Inventory of Parent and Peer Attachment.Mood, social responsiveness and quality of life were additionally assessed as secondary outcome measures. Reductions in attachment avoidance and increases in reports of attachment toward peers were reported after two weeks of OT treatment. Further, treatmentinduced changes were most pronounced for participants with less secure attachment towards their peers. indicating that normal variance at baseline modulated treatment response. OT treatment was additionally associated with changes in mood, indicating decreases in feelings of tension and (tentatively) anger in the OT group, not in the placebo group. Further, at the end of the two-week trial, both treatment groups (OT, placebo) reported to experience an increase in social responsiveness and quality of life, but the effects were only specific to the OTtreatment in terms of reports on 'social motivation'. In summary, the observed improvements on state and trait dimensions of attachment after a multiple-dose treatment with OT provide further evidence in support of a pivotal role of OT in promoting the experience of attachment. KEYWORDSOxytocin, State attachment, Trait attachment, Mood, Social responsiveness, Quality of life Oxytocin and attachment -Bernaerts et al.3

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Long-term oxytocin administration enhances the experience of attachment

Bernaerts

Prinsen

Berra

et al. 2017

Psychoneuroendocrinology

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“…Self-reported childhood caregiving experience, which could be associated with horizontal collectivistic orientation, has also been found to moderate prosocial oxytocin effects Riem, Bakermans-Kranenburg, Huffmeijer, & van IJzendoorn, 2013). Whereas we did not examine the role of past caregiving experiences in the present study, we think that collectivism is a more critical and proximal construct because it captures people's current construal and experience of social life.…”

Section: Discussionmentioning

confidence: 99%

The interplay of oxytocin and collectivistic orientation shields against negative effects of ostracism

Pfundmair

Aydin

Frey

et al. 2014

Journal of Experimental Social Psychology

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“…Both men (Meinlschmidt and Heim, 2007) and women (Riem et al, 2013) show altered responses to intranasal oxytocin after a childhood with significant disruptions in the parent-child relationship. Further, peripheral (urine) oxytocin levels were lower after a social encounter in children with early life histories in institutional settings compared with children who were reared in typical home settings (Wismer Fries et al, 2005).…”

Section: Gene By Environment Interactionsmentioning

confidence: 99%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

153

146

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The related neuropeptides oxytocin and vasopressin are involved in species-typical behavior, including social recognition behavior, maternal behavior, social bonding, communication, and aggression. A wealth of evidence from animal models demonstrates significant modulation of adult social behavior by both of these neuropeptides and their receptors. Over the last decade, there has been a flood of studies in humans also implicating a role for these neuropeptides in human social behavior. Despite popular assumptions that oxytocin is a molecule of social bonding in the infant brain, less mechanistic research emphasis has been placed on the potential role of these neuropeptides in the developmental emergence of the neural substrates of behavior. This review summarizes what is known and assumed about the developmental influence of these neuropeptides and outlines the important unanswered questions and testable hypotheses. There is tremendous translational need to understand the functions of these neuropeptides in mammalian experience-dependent development of the social brain. The activity of oxytocin and vasopressin during development should inform our understanding of individual, sex, and species differences in social behavior later in life.

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Does intranasal oxytocin promote prosocial behavior to an excluded fellow player? A randomized-controlled trial with Cyberball

Cited by 94 publications

References 53 publications

Long-term oxytocin administration enhances the experience of attachment

Long-term oxytocin administration enhances the experience of attachment

The interplay of oxytocin and collectivistic orientation shields against negative effects of ostracism

Developmental Perspectives on Oxytocin and Vasopressin

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