Does insomnia predict a high risk of cancer? A systematic review and meta‐analysis of cohort studies

Shi, Tingting; Min, Min; Sun, Chenyu; Zhang, Yun; Liang, Mingming; Sun, Yehuan

doi:10.1111/jsr.12876

Cited by 56 publications

(41 citation statements)

References 52 publications

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“…Although the pace of life aggregate did not significantly correlate with the health status of students, it was found that the item regarding less sleep is indeed related to worse health. This comes as no surprise as sleep was found to impact health in previous literature (e.g., Shi et al, 2020). Furthermore, eating slower was related to better health.…”

Section: Discussionsupporting

confidence: 61%

“…The same holds true for university students (e.g., Goldbach, Hoffmann, Hoppe, Pitz, & Thommes, 2020; Güzel & Glazer, 2019). Possible hypotheses about the consequences of an accelerated pace of life might be deduced from previous studies that have found a link to different health indicators such as cancer, coronary heart diseases (CHDs), and well‐being (e.g., Levine & Norenzayan, 1999; Melnikov, Krzhizhanovskaya, Lees, & Sloot, 2020; Royauté, Berdal, Garrison, & Dochtermann, 2018; Shi et al, 2020) as well as health‐related behavior (i.e., risky driving, Goldbach et al, 2020).…”

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confidence: 99%

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Pace of life and perceived stress in international students

et al. 2021

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An accelerated pace of life greatly impacts individuals' health and lifestyles. However, this imposition has not been systematically researched within a culturally diverse sample. Thus, this study aimed to explore the subjective experience of the pace of life and its correlates in a culturally diverse sample within a German university context. This was done to test whether students (N = 156) with a migration background from other countries (n = 105) differ from students without migration background (n = 51). The pace of life, life satisfaction, stress, work-life balance, and health were measured on an individual level along with sociodemographic variables through online questionnaires. The pace of life was found to be invariant across students from different cultural backgrounds and unrelated to the length of stay at the current university. Interrelations were found between pace of life and work-life balance, r = .21, p < .05. While this study revealed perceived stress to be generally prevalent among students, the relationship between a slower pace of life and increased stress levels, ß = −.17, p < .05, disappears when controlling for health, ß = −.26, p < .01, work-life balance, ß = −.28, p < .01, and life satisfaction, ß = −.25, p < .01, as well as sociodemographic variables (only gender and medium length of stay were significant.) Furthermore, a mediation effect, b = −1.89, 95% CI [−3.598, −0.463], revealed that students cope with a faster pace of life by effective time management, which also leads to better work-life balance and in turn reduces the experienced level of stress. Future research should examine psychological mechanisms more extensively in longitudinal research and apply interventional designs to help students prevent and manage stress in the era of a fast-paced life.

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Section: Discussionsupporting

confidence: 61%

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confidence: 99%

Pace of life and perceived stress in international students

et al. 2021

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“…In the general population, about a third of individuals have sleep complaints, and nearly 10% fulfill the diagnostic criteria for chronic insomnia disorder (CID). 1 CID has a strong impact on quality of life and is a risk factor for the development of other disorders, including psychological disease, 2 , 3 cardiovascular disease, 4 diabetes, 5 certain cancers, 6 obesity, 7 and functional decline. This has substantial public health implications.…”

Section: Introductionmentioning

confidence: 99%

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Xia¹,

Zhang²,

Niu³

et al. 2021

NSS

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Purpose To examine whether associations exist between chronic insomnia disorder (CID) and overlooked inflammatory factors (Serum amyloid protein A [SAA]), tumor necrosis factor [TNF]-α, granulocyte-macrophage colony-stimulating factor [GM-CSF], and regulated on activation and normal T cell expressed and presumably secreted [RANTES]). Patients and Methods A total of 65 CID patients and 39 sex- and age-matched good sleeper (GS) controls participated in this study. They completed a baseline survey to collect data on demographics, and were elevated sleep and mood by Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), 17-item Hamilton Depression Rating Scale (HAMD-17) and 14-item Hamilton Anxiety Rating Scale (HAMA-14), respectively. The blood samples were collected and tested the serum levels of SAA, TNF-α, GM-CSF and RANTES. Results The CID group had higher serum levels of SAA, TNF-α, and GM-CSF and a lower level of RANTES than the GS group. In the Spearman correlation analysis, SAA and GM-CSF positively correlated with the PSQI and AIS scores. After controlling for sex, HAMD-17 score, and HAMA-14 score, the partial correlation analysis showed that GM-CSF was positively correlated with PSQI score. Further stepwise linear regression analyses showed that GM-CSF was positively associated with the PSQI and AIS scores, while RANTES was negatively associated with them, and SAA was positively associated with just the AIS score. Conclusion The serum levels of inflammatory mediators (SAA, TNF-α, and GM-CSF) were significantly elevated and the level of RANTES was significantly decreased in CID patients and, to some extent, the changes are related to the severity of insomnia. These findings may help us to improve interventions to prevent the biological consequences of CID by inhibiting inflammation, thereby promoting health.

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“…Nonetheless, the results for total sleep duration were similarly null when we excluded women who reported napping. Furthermore, although short total sleep duration has been considered a surrogate for greater light-at-light exposure, many factors (such as the proportion of [39] and insomnia [40] with breast cancer risk, and from prospective studies of individual-level data on light-at-night exposures [10,41,42] does not suggest that these factors are related to breast cancer aetiology. Further, little or no evidence for the carcinogenicity of long or short sleep duration is provided by evidence from meta-analyses of data on other sex hormone-related cancers (including endometrial cancer, ovarian cancer, and prostate cancer), although there are relatively few published data for endometrial cancer and for ovarian cancer [16].…”

Section: Discussionmentioning

confidence: 99%

Sleep duration and breast cancer incidence: results from the million women study and a meta-analysis of published prospective studies

et al. 2019

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Study objectives: To investigate the association between sleep duration and breast cancer incidence, we examined the association in a large UK prospective study and conducted a meta-analysis of prospective studies. Methods: In the Million Women Study, usual sleep duration over a 24-hour period was collected in 2001 for 713,150 participants without prior cancer, heart problems, stroke or diabetes (mean age=60 years). Follow-up for breast cancer was by record linkage to national cancer registry data for 14.3 years on average from the 3-year resurvey. Cox regression models yielded multivariable-adjusted breast cancer relative risks (RR) and 95% confidence intervals (CIs) for sleep duration categories. Published prospective studies of sleep duration and breast cancer risk were included in a metaanalysis, which estimated the inverse-variance weighted average of study-specific log RRs for short and for long versus average duration sleep. Results: After excluding the first five years to minimise reverse causation bias in the Million Women Study, 24,476 women developed breast cancer. Compared with 7-8 hours of sleep, the RRs for <6, 6, 9, and >9 hours of sleep were 1.01 (95%CI, 0.95-1.07), 0.99 (0.96-1.03), 1.01 (0.96-1.06), and 1.03 (0.95-1.12), respectively. In a meta-analysis of 14 prospective studies plus the Million Women Study, including 65,410 breast cancer cases, neither short (RR<7 hours=0.99 [0.98-1.01]) nor long (RR>8 hours=1.01 [0.98-1.04]) versus average duration sleep was associated with breast cancer risk. Conclusions: The totality of the prospective evidence does not support an association between sleep duration and breast cancer risk.

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Does insomnia predict a high risk of cancer? A systematic review and meta‐analysis of cohort studies

Cited by 56 publications

References 52 publications

Pace of life and perceived stress in international students

Pace of life and perceived stress in international students

Relationships Between a Range of Inflammatory Biomarkers and Subjective Sleep Quality in Chronic Insomnia Patients: A Clinical Study

Sleep duration and breast cancer incidence: results from the million women study and a meta-analysis of published prospective studies

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