Does infrared or ultraviolet light damage the lens?

Söderberg, Per G.; Talebizadeh, Nooshin; Yu, Zhu Liang; Galichanin, Konstantin

doi:10.1038/eye.2015.266

Cited by 30 publications

(21 citation statements)

References 18 publications

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“…Different risk factors are known for this disease, for example diabetes (Xu et al 2016), but one of the main and most diffused risk factor is long-term ultraviolet (UV) radiation exposure. Both UV-A and UV-B are absorbed by the lens and act with different mechanisms in inducing cataractogenesis, with a progressive chronic photochemical damage (West 1999;L€ ofgren 2016;S€ oderberg et al 2016). The lens nucleus is particularly susceptible to UV-A-induced stress, able to determine changes in the lens fluorescence, increased yellowing and loss of pyridine nucleotides (Linetsky et al 2014), by modulating gene expression and apoptotic stimuli in the lens epithelial cells (Andley et al 2000(Andley et al , 2004.…”

Section: Introductionmentioning

confidence: 99%

Cataract frequency and subtypes involved in workers assessed for their solar radiation exposure: a systematic review

Modenese

Gobba

2018

Acta Ophthalmologica

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Cataract is currently the primary cause of blindness worldwide, and one of its main risk factors is solar ultraviolet radiation exposure. According to the localization of lens opacities, three main subtypes of cataract are recognized: nuclear, cortical and posterior subcapsular cataract. One of the main determinants of individual long-term solar radiation exposure is outdoor work. We systematically reviewed scientific literature from the last 20 years to update the recent development of research on the risk of cataract in outdoor workers and on the specific subtypes involved, also investigating the methods applied to evaluate the occupational risk. A total of 15 studies were included in the review, of which 12 showed a positive association. The studies confirm the relationship of long-term occupational solar radiation exposure with cortical cataract and give new support for nuclear cataract, although no substantial new data were available to support a relation with the posterior subcapsular subtype. In most of the studies, the exposure assessment was not adequate to support a representative evaluation of the ocular risk; however, outdoor work is clearly a relevant risk factor for cataract. Further research providing a better evaluation of the relation between solar radiation exposure levels and lens damage in workers is needed and aimed to establish adequate occupational exposure limits and better preventive measures, studying also their effectiveness.

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Section: Introductionmentioning

confidence: 99%

Cataract frequency and subtypes involved in workers assessed for their solar radiation exposure: a systematic review

Modenese

Gobba

2018

Acta Ophthalmologica

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“… 12 Exposure to UVR from sunlight has been mainly associated with the risk of age-related cortical cataract. 13 – 16 Climatic UVR has been positively correlated with cataract prevalence in the Indigenous Australian population. 6 …”

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confidence: 99%

Association of Age-Related Cataract With Skin Cancer in an Australian Population

Sharma

Lang

Khadka

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Ultraviolet radiation from sunlight contributes to age-related cataract and skin cancer. The EPHA2 gene is implicated in both these diseases. The purpose of this study was to determine whether age-related cataract and skin cancer are associated in a cohort of older Australians. METHODS. A cross-sectional study was performed using the Historical Cohort of the Registry of Senior Australians. Individuals aged ≥65 years or aged ≥50 years and of Aboriginal or Torres Strait Islander descent, who had an aged care eligibility assessment between July 2005 and June 2015, and had a history of cataract surgery and/or skin cancer according to the Australian Government Medicare Benefits Schedule dataset, during the 3-year period prior, were evaluated (N = 599,316). A multivariable logistic regression model was used to determine association and multiple hypothesis correction was employed. RESULTS. Of the evaluated individuals, 87,097 (14.5%) had a history of cataract and 170,251 (28.4%) a history of skin cancer. Among those with a history of cataract, 20,497 (23.5%), 1127 (1.3%), and 14,730 (16.9%) individuals had a concurrent history of keratinocyte, melanoma, and premalignant/solar keratosis, respectively. Those with a history of cataract were 19% more likely to have a history of skin cancer (odds ratio [OR], 1.19; 95% confidence interval [CI], (1.17-1.21). Co-occurrence of keratinocyte skin cancer was 16% (OR, 1.16; 95% CI, 1.14-1.18), melanoma 21% (OR, 1.21; 95% CI, 1.13-1.29), and premalignant/solar keratosis 19% (OR, 1.19; 95% CI, 1.17-1.22) more in the presence than absence of history of cataract. CONCLUSIONS. Age-related cataract is positively associated with skin cancer and its subtypes, including premalignant lesions in an older Australian population.

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“… 18 Although the procedure involved long-term (30 minutes of) exposure to UVA light, this study showed that the changes observed using SD-OCT and mfERG are not similar in nature or magnitude to other phototoxicity conditions described previously. This difference could be explained by the protective features of the anterior segment 25 , 26 and the low UVA light intensity of the procedure relative to the intensity associated with typical phototoxicity conditions. The SD-OCT findings also reflected an increase in central macular thickness, which is the opposite of the typical thinning seen in outer retinal abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Macular phototoxicity after corneal cross-linking

Barbisan¹,

Viturino²,

Souto³

et al. 2018

OPTH

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PurposeTo assess potential vascular, structural, and functional changes to the macula in patients with keratoconus that underwent ultraviolet A (UVA)–riboflavin-mediated corneal collagen cross-linking (CXL) therapy.Patients and methodsSeventeen eyes from 17 patients of age 16 years or older with keratoconus undergoing CXL treatment were studied. The same eye served as its own control (before CXL vs after CXL). Eyes were evaluated in terms of best-corrected visual acuity (BCVA), refractive error, intraocular pressure, Amsler grid, retinography, fluorescein angiography, autofluorescence, and spectral domain optical coherence tomography (SD-OCT) prior to CXL and 7 and 30 days after treatment. Multifocal electroretinography (mfERG) was recorded prior to and 7 days after CXL.ResultsMean (SD) BCVA by logMAR chart was 0.47 (±0.12) pre-CXL, 0.55 (±0.15) 7 days post-CXL (P=0.57), and 0.46 (±0.10) 30 days post-CXL (P=0.87). Mean (SD) SD-OCT central macular thickness (µm) was 253.62 (±20.9) pre-CXL, 260.5 (±18.7) 7 days post-CXL (P=0.48), and 256.44 (±21.6) 30 days post-CXL (P=0.69). In 12 eyes, mfERG revealed a statistically significant increase (P=0.0353) in P1 latency (ms) of ring four from the pre-CXL period (39.45±2.05) to 7 days post-CXL (41.04±1.28) period. Regression analysis showed that the increase in P1 latency was correlated with the increase in central macular thickness (P=0.027). Furthermore, nine patients experienced a significant decrease in P1 amplitudes of rings 1 (P=0.0014), 2 (P=0.0029), 3 (P=0.0037), 4 (P=0.0014), and 5 (P=0.0012) from pre-CXL to 7 days post-CXL. Conclusion: In this pilot study, most of the patients exhibited slight changes in their mfERG parameters and OCT thickness, despite a lack of vascular abnormalities observed on fluorescein angiography/autofluorescence imaging, no alteration in BCVA, and no reports of symptoms. These changes could, therefore, be categorized as a mild subclinical effect of the corneal cross-linking procedure.

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Does infrared or ultraviolet light damage the lens?

Cited by 30 publications

References 18 publications

Cataract frequency and subtypes involved in workers assessed for their solar radiation exposure: a systematic review

Cataract frequency and subtypes involved in workers assessed for their solar radiation exposure: a systematic review

Association of Age-Related Cataract With Skin Cancer in an Australian Population

Macular phototoxicity after corneal cross-linking

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