Does Inflammation Contribute to Cancer Incidence and Mortality during Aging? A Conceptual Review

Guerville, Florent; Bourdel-Marchasson, I.; Déchanet‐Merville, Julie; Pellegrin, Isabelle; Soubeyran, Pierre; Appay, Victor; Lemoine, Maël

doi:10.3390/cancers14071622

Cited by 9 publications

(8 citation statements)

References 92 publications

(110 reference statements)

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“…Inflammation is a known risk factor for cardiovascular disease and has been implicated in the pathogenesis of MI. Therefore, a weaker inflammatory response to pneumonia could result in a lower risk of MI in these patients [ 26 , 27 ]. Secondly, patients with these underlying conditions may have a higher prevalence of comorbidities that are protective against MI.…”

Section: Discussionmentioning

confidence: 99%

Acute Myocardial Infarction–Related Hospitalizations in Non-elderly Patients with Pneumonia: a Population-Based Study

Younis

Loh

Singh

et al. 2023

SN Compr. Clin. Med.

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The objective is to study factors that increase the likelihood of acute myocardial infarction (AMI) in hospitalized adult non-elderly patients with pneumonia compared to other medical inpatients and to understand the utilization rate of percutaneous coronary intervention (PCI) for AMI in inpatients with pneumonia and its related impact on hospitalization stay and cost. A population-based study was conducted using the Nationwide Inpatient Sample (NIS, 2019) with adult non-elderly inpatients (age 18–65 years) with a medical condition as their primary diagnosis and a co-diagnosis of pneumonia during hospitalization stay. This study sample was divided by the primary diagnosis of AMI versus other medical conditions (non-AMI). A logistic regression model was used to evaluate the odds ratio (OR) of predictors associated with AMI in patients with pneumonia. The results showed a direct relationship between increasing age and the likelihood of AMI in pneumonia inpatients with three times higher odds seen in 51–65 years of age (OR 2.95, 95% CI 2.82–3.09). The comorbidities included complicated hypertension (OR 2.84, 95% CI 2.78–2.89), diabetes with complications (OR 1.27, 95% CI 1.24–1.29), and drug abuse (OR 1.27, 95% CI 1.22–1.31) that increased the likelihood of AMI-related hospitalization. The utilization rate of surgical treatment (PCI) was 14.37% for the management of AMI in inpatients with pneumonia. Inpatients co-diagnosed with pneumonia and comorbidities such as hypertension and diabetes were more likely to be hospitalized for AMI. These at-risk patients should be considered for early risk stratification. Utilization of PCI was associated with a lower in-hospital mortality rate.

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Section: Discussionmentioning

confidence: 99%

Acute Myocardial Infarction–Related Hospitalizations in Non-elderly Patients with Pneumonia: a Population-Based Study

Younis

Loh

Singh

et al. 2023

SN Compr. Clin. Med.

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“…Impaired endothelial function is thought to contribute to the increased cardiovascular risk ( Craighead et al, 2020 ), vascular aging associated with atherosclerotic ischemic stroke ( Koutsaliaris et al, 2022 ), and oxidative stress–inflammation in chronic kidney disease ( Ebert et al, 2021 ). Aging is associated with chronic low-grade inflammation, cancer incidence, and mortality ( Guerville et al, 2022 ), a physiological process mediated by numerous biological and genetic pathways, which are a driving force for all age-related diseases ( Li et al, 2021 ). Cancer often arises in the context of an altered tissue microenvironment landscape ( Laconi et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

Phua

2023

Front. Aging

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Aging-related hypoxia, oxidative stress, and inflammation pathophysiology are closely associated with human age-related carcinogenesis and chronic diseases. However, the connection between hypoxia and hormonal cell signaling pathways is unclear, but such human age-related comorbid diseases do coincide with the middle-aging period of declining sex hormonal signaling. This scoping review evaluates the relevant interdisciplinary evidence to assess the systems biology of function, regulation, and homeostasis in order to discern and decipher the etiology of the connection between hypoxia and hormonal signaling in human age-related comorbid diseases. The hypothesis charts the accumulating evidence to support the development of a hypoxic milieu and oxidative stress-inflammation pathophysiology in middle-aged individuals, as well as the induction of amyloidosis, autophagy, and epithelial-to-mesenchymal transition in aging-related degeneration. Taken together, this new approach and strategy can provide the clarity of concepts and patterns to determine the causes of declining vascularity hemodynamics (blood flow) and physiological oxygenation perfusion (oxygen bioavailability) in relation to oxygen homeostasis and vascularity that cause hypoxia (hypovascularity hypoxia). The middle-aging hypovascularity hypoxia hypothesis could provide the mechanistic interface connecting the endocrine, nitric oxide, and oxygen homeostasis signaling that is closely linked to the progressive conditions of degenerative hypertrophy, atrophy, fibrosis, and neoplasm. An in-depth understanding of these intrinsic biological processes of the developing middle-aged hypoxia could provide potential new strategies for time-dependent therapies in maintaining healthspan for healthy lifestyle aging, medical cost savings, and health system sustainability.

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“… 25 Inflammation contributes to carcinogenesis through several stages, particularly reactive oxygen species produced by activated inflammatory cells, which could promote genomic instability/DNA mutations. 26 Considering its rapid, widely available, and relatively inexpensive assessment through routine blood count analysis, NLR in peripheral blood is being increasingly studied as a systemic inflammatory marker. 27 Our study showed NLR was elevated in LC compared with HC, while no significant difference was found between LC and cirrhotic HCC.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio Can Distinguish Patients with Liver Cirrhosis from Healthy People but Cannot Distinguish Patients with Cirrhotic Hepatocellular Carcinoma from Patients with Liver Cirrhosis

Zhu¹,

Zhang²

2022

JHC

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Purpose Identifying cirrhotic hepatocellular carcinoma (HCC) during liver cirrhosis (LC) stage is pivotal for improving the clinical outcomes of cirrhotic HCC patients. Inflammation-driven markers play a crucial role in tumorigenesis and tumor progression. Neutrophil-to-lymphocyte ratio (NLR) is an inflammatory response marker. This study aimed to evaluate the ability of NLR to distinguish cirrhotic HCC from LC. Methods Data of healthy control (HC) people, LC patients, cirrhotic HCC patients, and non-cirrhotic HCC patients were retrospectively analyzed. Mann–Whitney U test and Chi-squared test were used to compare demographic and clinical parameters in different groups. Spearman correlation analysis was used to assess correlations. Receiver operating characteristic (ROC) curves were performed to determine diagnostic accuracy. Results A total of 419 participants were enrolled in this study, including 152 HC people, 131 LC patients, 96 cirrhotic HCC patients, and 40 non-cirrhotic HCC patients. Level of NLR was elevated significantly in LC compared with HC ( P < 0.001). No significant differences were found for NLR between LC and cirrhotic HCC ( P = 0.083), as well as between cirrhotic HCC and non-cirrhotic HCC ( P = 0.729). NLR was positively correlated with platelet-to-lymphocyte ratio ( r = 0.33, P < 0.001). The area under the ROC curve (AUC) value for NLR to distinguish LC from HC was 0.759 ( P < 0.001), and AUC value to distinguish cirrhotic HCC from LC was 0.567 ( P = 0.083), and AUC value to distinguish non-cirrhotic HCC from cirrhotic HCC was 0.519 (0.415–0.623) ( P = 0.729). Conclusion NLR can distinguish LC from HC but cannot not distinguish cirrhotic HCC from LC.

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Does Inflammation Contribute to Cancer Incidence and Mortality during Aging? A Conceptual Review

Cited by 9 publications

References 92 publications

Acute Myocardial Infarction–Related Hospitalizations in Non-elderly Patients with Pneumonia: a Population-Based Study

Acute Myocardial Infarction–Related Hospitalizations in Non-elderly Patients with Pneumonia: a Population-Based Study

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

Neutrophil-to-Lymphocyte Ratio Can Distinguish Patients with Liver Cirrhosis from Healthy People but Cannot Distinguish Patients with Cirrhotic Hepatocellular Carcinoma from Patients with Liver Cirrhosis

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