Does Induction Chemotherapy Still Have a Role in Larynx Preservation Strategies? The Experience of Institut Catala d'Oncologia in Stage III Larynx Carcinoma

Majem, Margarita; Mesı́a, Ricard; Mañós, M.; Gómez, Juana; Galiana, R.; Cardenal, Felipe; Juan, Amparo; Montes, Ana; Pérez, F.J.; Nogués, Julio J.; Llluch, Josep Ramon Germa

doi:10.1097/01.mlg.0000231736.08477.47

Cited by 24 publications

(8 citation statements)

References 14 publications

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“…This triplet state can interact with ground-state oxygen with energy transfer leading to production of a reactive species, singlet oxygen, which at very low doses can cause cell proliferation and tissue stimulation (Plaetzer et al 2002). Moreover, experimental evidence has shown that nitric oxide might be involved in the cellular response to photons (Majem et al 2006), as NIR is associated with reduced NO production in either rat stroke model (Leung et al 2002) or arthritis model (Moriyama et al 2005). Thus NIR may also play a role in inhibiting NO neurotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Near infrared radiation rescues mitochondrial dysfunction in cortical neurons after oxygen-glucose deprivation

Liu

Zhao

et al. 2014

Metab Brain Dis

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Near infrared radiation (NIR) is known to penetrate and affect biological systems in multiple ways. Recently, a series of experimental studies suggested that low intensity NIR may protect neuronal cells against a wide range of insults that mimic diseases such as stroke, brain trauma and neuro-degeneration. However, the potential molecular mechanisms of neuroprotection with NIR remain poorly defined. In this study, we tested the hypothesis that low intensity NIR may attenuate hypoxia/ischemia-induced mitochondrial dysfunction in neurons. Primary cortical mouse neuronal cultures were subjected to 4 h oxygen-glucose deprivation followed by reoxygenation for 2 h, neurons were then treated with a 2 min exposure to 810-nm NIR. Mitochondrial function markers including MTT reduction and mitochondria membrane potential were measured at 2 h after treatment. Neurotoxicity was quantified 20 h later. Our results showed that 4 h oxygen-glucose deprivation plus 20 h reoxygenation caused 33.8±3.4 % of neuron death, while NIR exposure significantly reduced neuronal death to 23.6±2.9 %. MTT reduction rate was reduced to 75.9±2.7 % by oxygen-glucose deprivation compared to normoxic controls, but NIR exposure significantly rescued MTT reduction to 87.6±4.5 %. Furthermore, after oxygen-glucose deprivation, mitochondria membrane potential was reduced to 48.9±4.39 % of normoxic control, while NIR exposure significantly ameliorated this reduction to 89.6±13.9 % of normoxic control. Finally, NIR significantly rescued OGD-induced ATP production decline at 20 min after NIR. These findings suggest that low intensity NIR can protect neurons against oxygen-glucose deprivation by rescuing mitochondrial function and restoring neuronal energetics.

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Section: Discussionmentioning

confidence: 99%

Near infrared radiation rescues mitochondrial dysfunction in cortical neurons after oxygen-glucose deprivation

Liu

Zhao

et al. 2014

Metab Brain Dis

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“…Induction chemotherapy or concurrent chemoradiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer (Majem et al, 2006;Dietz et al, 2009;Haigentz et al, 2012). However, systemic cancer chemotherapy is frequently accompanied by strong side effects and acquired drug resistance.…”

Section: Discussionmentioning

confidence: 99%

EGFR-targeted poly(ethylene glycol)-distearoylphosphatidylethanolamine micelle loaded with paclitaxel for laryngeal cancer: preparation, characterization andin vitroevaluation

et al. 2014

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The objective of this study was to evaluate the potential of using polymeric micelles modified with a peptide (termed GE11) ligand of epidermal growth factor receptor as the targeted carriers to achieve increased accumulation in laryngeal cancer and enhanced intracellular delivery for the encapsulated anticancer drugs. Poly (ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) micelles containing paclitaxel were prepared via film-hydration method followed by investigation of in vitro release of paclitaxel in phosphate-buffered saline. The average size of GE11-PEG-DSPE/paclitaxel micelle and mPEG-DSPE/paclitaxel were 35 ± 2.8 nm [the polydispersity index (PDI) ¼ 0.207] and 28 ± 2.1 nm (PDI ¼ 0.154), respectively. Micelles with or without GE11-modified had similar physicochemical properties. Transmission electron microscopy showed that the micelles were homogeneous and spherical in shape. Encapsulation efficiency and drug loading of the micelle were 74.11 ± 3.89% and 3.58 ± 2.82%, respectively. The in vitro targeting characteristic of GE11-modified micelles was investigated by observing the level of cellular uptake of fluorescent coumarin-6-loaded micelles on EGFR overexpressed human laryngeal cancer cell line Hep-2 and EGFR low-expressed human leukemic cell line U-937. Hep-2 cell proliferation was significantly inhibited by GE11-PEG-DSPE/paclitaxel micelle compared to mPEG-DSPE/paclitaxel micelle and Taxol in vitro. Our results suggested that GE11-PEG-DSPE micelle could be a promising strategy for enhancing paclitaxel's chemotherapeutic effects on EGFR over-expressed cancer cells.

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“…A recent study on advanced laryngeal cancers has concluded that patients with complete response to induction chemotherapy (cisplatin) have a high probability of cure after hyperfractionated radiotherapy (Majem et al 2006). Gene therapy promises to improve the outcome of laryngeal cancer treatment in the near future.…”

Section: Tumour Site-related Treatmentsmentioning

confidence: 99%

A review of risk factors and genetic alterations in head and neck carcinogenesis and implications for current and future approaches to treatment

Marcu

Yeoh

2009

J Cancer Res Clin Oncol

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Head and neck cancer is the fifth most common cancer worldwide but the most common malignant disease site in central Asia. The treatment of head and neck cancer is one of the most challenging in clinical oncology because of the high content of hypoxic cells of the cancer which increases resistance to therapy and also because of the high capacity of the cancer to regrow during treatment. For unresectable tumours, radiotherapy and chemotherapy alone or more often in combination is the treatment of choice. The aim of this paper is to review current understanding of carcinogenesis of head and neck cancer in relation to predisposing risk factors in general and for specific sub-sites and how these risk factors interact with the main reported genetic alterations in the progression of the cancer. The implications of these changes in determining choice of therapy are also discussed from a brief historical perspective of the various treatment approaches of head and neck cancer.

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Does Induction Chemotherapy Still Have a Role in Larynx Preservation Strategies? The Experience of Institut Catala d'Oncologia in Stage III Larynx Carcinoma

Cited by 24 publications

References 14 publications

Near infrared radiation rescues mitochondrial dysfunction in cortical neurons after oxygen-glucose deprivation

Near infrared radiation rescues mitochondrial dysfunction in cortical neurons after oxygen-glucose deprivation

EGFR-targeted poly(ethylene glycol)-distearoylphosphatidylethanolamine micelle loaded with paclitaxel for laryngeal cancer: preparation, characterization andin vitroevaluation

A review of risk factors and genetic alterations in head and neck carcinogenesis and implications for current and future approaches to treatment

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