Does Hypoxia‐Inducible Factor ‐1 α (HIF‐1α) C1772T polymorphism predict short‐term prognosis in patients with oral squamous cell carcinoma (OSCC)?

Abstract

Our study showed that CT genotype for C1772T polymorphism of HIF-1α predisposes to aggressive tumor phenotype in patients with OSCC. Moreover, patients with CT genotype had poor survival rate as compared to CC genotype. A cut-off value of 460 pg/mL of HIF-1α can help to segregate patients with OSCC from healthy controls.

Correlation between hypoxia-inducible factor-1α C1772T/G1790A polymorphisms and head and neck cancer risk: a meta-analysis

“…2 Forest plot for the association of the HIF-1α C1772T polymorphism and HNC risk under a recessive genetic model Fig. 3 Forest plot for the association of the HIF-1α G1790 polymorphism and HNC risk under the allele genetic model stratified by source of control inconclusive [32,34,[36][37][38][39][40]. This might be because of the limitations of these studies, such as ethnic differences, control source differences, small sample sizes and different methodologies.…”

“…To the best of our knowledge, no studies have evaluated HIF-1αC1772T in the progression of HNC. In this meta-analysis, seven studies were ultimately enrolled for the C1772T polymorphism [32,34,[36][37][38][39][40], and six studies were included for the G1790A polymorphism [32,34,[37][38][39][40]. Overall, the results demonstrated that the HIF-1α C1772T polymorphism is an important factor in determining the increased risk of HNC (OR = 2.27, 95% CI = 1.17-4.42 for the homozygous model; OR = 11.53, 95% CI = 1.11-120.4 for the recessive model).…”

“…After excluding animal studies, reviews, repeated studies, conference studies and reading the full text, 7 original Fig. 1 The process of study selection studies [32,34,[36][37][38][39][40] were ultimately included. The article selection process is shown in Fig.…”

“…Among the 7 enrolled studies, 7 studies were ultimately correlated with the C1772T polymorphism [32,34,[36][37][38][39][40], and 6 studies were related to the G1790A polymorphism [30,32,[37][38][39][40]. Overall, the meta-analysis included five articles conducted on oral cancer (OC), one article on glottic laryngeal cancer (GLC), and one on HNC.…”

“…In recent years, several researchers have reported the potential relationship between HIF-1α polymorphisms and susceptibility to HNC, but the results have been conflicting [32,34,[36][37][38][39][40]. Thus, it is essential to conduct a comprehensive meta-analysis with high statistical power to study the role of HIF-1α C1772T and G1790A polymorphisms in the progression of HNC.…”