Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy?

Vauloup‐Fellous, Christelle; Picone, Olivier; Cordier, A.; Parent-du-Châtelet, Isabelle; Sénat, Marie-Victoire; Frydman, René; Grangeot-Keros, L.

doi:10.1016/j.jcv.2009.09.003

Cited by 216 publications

(204 citation statements)

References 29 publications

(38 reference statements)

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“…Because some of the behaviors we studied (e.g., kissing, sharing food) represent cultural norms or usual mother-child intimacy among some subgroups in the United States, it will be important to understand how to frame the behavioral guidelines in a way that increases the likelihood that women will accept them and incorporate them into their daily routines. Previous research suggests that women are receptive to such guidelines even though they may represent a departure from cultural norms (Adler, 2011;Ross et al, 2008;Vauloup-Fellous et al, 2009). Because CMV reactivation may be responsible for some congenital CMV infections, not all congenital infections may be preventable by avoiding CMV exposures.…”

Section: Discussionmentioning

confidence: 99%

Awareness of and behaviors related to child-to-mother transmission of cytomegalovirus

Cannon

Westbrook

Levis

et al. 2012

Preventive Medicine

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Objective-Congenital cytomegalovirus (CMV) infection is a common cause of hearing loss and intellectual disability. We assessed CMV knowledge and the frequency of women's behaviors that may enable CMV transmission to inform strategies for communicating prevention messages to women. Results-Only 7% of men and 13% of women had heard of congenital CMV. Women with children under age 19 (n=918) practiced the following risk behaviors at least once per week while their youngest child was still in diapers: kissing on the lips (69%), sharing utensils (42%), sharing cups (37%), and sharing food (62%). Women practiced protective, hand cleansing behaviors most of the time or always after: changing a dirty diaper (95%), changing a wet diaper (85%), or wiping the child's nose (65%), but less commonly after handling the child's toys (26%). Methods-WeConclusions-Few women are aware of CMV and most regularly practice behaviors that may place them at risk when interacting with young children. Women should be informed of practices that can reduce their risk of CMV infection during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Awareness of and behaviors related to child-to-mother transmission of cytomegalovirus

Cannon

Westbrook

Levis

et al. 2012

Preventive Medicine

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“…To date, of 37 pregnant women with a child shedding CMV, we have observed only one who received hygienic precautions and seroconverted to CMV during pregnancy, compared to infection rates of 42% for 64 of 154 nonpregnant women with a child shedding CMV, including seronegative women who were trying to conceive [22]. This observation has recently been confirmed and expanded in a French study where 5312 pregnant women were offered CMV serologic screening during pregnancy [12]. Of these women, 97.4% agreed to screening and signed a consent.…”

Section: Interventionsmentioning

confidence: 59%

“…When adjusted for the number of woman-weeks observed, the rate prior to 12 weeks gestation was 0.035% per woman-week compared to a rate of 0.008% per woman-week after intervention (P = 0.005). Maternal primary infections and seroconversions were distributed evenly throughout gestation [12].…”

Section: Interventionsmentioning

confidence: 99%

“…The Italians have capitalized on national serologic screening to develop and evaluate methods to diagnose maternal and fetal CMV infections including the CMV IgG avidity assay, and to test interventions such as CMV immunoglobulin [10,11]. The French have used serologic screening to evaluate the role of maternal education about CMV and the role of hygienic intervention to prevent maternal acquisition of CMV during pregnancy [12]. This paper will highlight recent developments that make either universal or limited serologic screening for CMV during pregnancy potentially attractive.…”

Section: Introductionmentioning

confidence: 99%

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Screening for cytomegalovirus during pregnancy

Adler

Nigro

Pereira

2010

American Journal of Obstetrics and Gynecology

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The epidemiology and pathogenesis of CMV infections among pregnant women have been intensely studied over the last three decades. This paper highlights recent developments that make either universal or limited serologic screening for CMV during pregnancy potentially attractive. The developments include an understanding of the pathogenesis of CMV infections, a knowledge of high-risk women, the availability of accurate methods for the serologic diagnosis of a primary CMV infection using either single or serial blood samples, accurate methods for the diagnosis of fetal infection via amniotic fluid, sensitive fetal and placental indicators for neonatal outcomes, and the availability of potentially effective interventions.

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“…Although the above studies were not powered to answer the key questions and suffered from substantial methodological limitations 6 , they were important pilot studies and they were instrumental to the design of subsequent larger studies. More recently, a French study conducted among more than 5000 pregnant women at a single hospital in Paris showed a reduction from 0.4% to 0.2% in the seroconversion rate following CMV counseling 7 . However, the con- at delivery who were neither tested for, nor informed about CMV during pregnancy, and who had a serum sample stored at the time screening for foetal aneuploidy.…”

mentioning

confidence: 99%

An effective and feasible approach to prevention of primary cytomegalovirus infection in pregnancy

et al. 2015

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In the absence of a cytomegalovirus (CMV) vaccine, other strategies for prevention of primary infection in pregnancy should be considered. Behavioural interventions have been reported to significantly decrease seroconversion rate among seronegative pregnant women. We report here on a recently completed controlled study in which seronegative women at high risk of infection because of close contacts with children <36 months, were identified and informed about risky and protective behaviours. Informed women seroconverted at a significantly lower rate than non-informed women.When in 1974 Elek and Stern published their paper with the committing title 'Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero' 1 they could not imagine that 40 years later the CMV vaccine would still be an elusive target, and the hope that '. . . the use of such a vaccine in adolescent girls would reduce the incidence of primary cytomegalovirus infection in pregnancy and thus eliminate fetal brain damage due to this cause' would remain unmet. Although considered top priority 2 and highly desirable 3 , the availability of a CMV vaccine is not foreseen for the near future. Sadly, nowadays, seronegative pregnant women are at the same risk of acquiring a primary CMV infection as they were decades ago. Congenital CMV is perpetuated by the lack of public awareness, serologic screening, unavailability of an effective vaccine and of effective therapeutic treatments.On the other hand, our knowledge about the epidemiology of the virus and its ways of transmission, together with the availability of reliable serology assays have the potential, when properly used, to markedly reduce the incidence of primary infection in pregnant women and, ultimately, of congenital infection.In two small studies conducted in Virginia, US, in 1996 and 2004 the group of S. Adler reported that: (1) behavioural interventions such as frequent hand washing and avoiding close contacts with young children had the potential of reducing the risk of primary CMV infection; and (2) pregnant women were more motivated to follow behavioural interventions than were nonpregnant women 4,5 . In other words, four conditions had to be satisfied for hygiene recommendations to be effective, namely the woman had: (1) to be pregnant; (2) to

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Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy?

Cited by 216 publications

References 29 publications

Awareness of and behaviors related to child-to-mother transmission of cytomegalovirus

Awareness of and behaviors related to child-to-mother transmission of cytomegalovirus

Screening for cytomegalovirus during pregnancy

An effective and feasible approach to prevention of primary cytomegalovirus infection in pregnancy

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