Objective: This study was designed to determine the pattern of anaemia among HIV positive patients taking HAART. Study Design: Cross-sectional study. Place and Duration: Diagnostic and research Laboratory Liaquat university of Medical and health sciences Jamshoro, Hyderabad. January 2022-December 2022. Methods: Total 250 HIV patients (aged 18 years and above) of both genders taking HAART for at least the past six months. After taking written informed consent, data was recorded with the help of a structured questionnaire that contained questions regarding basic bio-data and medical history, along with the interpretation of general physical and systemic examination. A blood complete picture was done to evaluate baseline haematological parameters. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 22.0. Results: The mean age of the patients was 32.09 (±SD12.165). Most of the individuals, i.e., 160 (64%), were males, and the number of females was 90 (36%). The mean viral load was 2674.60. Anaemia was present in 210 (84%) patients and 40 (16%)non-anemic with standard parameters. Among anaemic patients, 130 52% had mild disease, moderate anaemia was found in 105 (42%), and only a few (n=15) 6% had severe anaemia.