Does Helicobacter pylori infection play a role in iron deficiency anemia in hemodialysis patients?

El-Said, Heba W.; Ahb, Attallah; Ali-Eldin, Zainab A.

doi:10.5414/cn109034

Cited by 8 publications

(7 citation statements)

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“…Many studies did not find a significant relationship between anemia and iron deficiency with HP positivity and other endoscopic findings except bleeding [61]. We detected significant relationship between duedonitis and lower hemoglobin.…”

Section: Discussioncontrasting

confidence: 37%

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

et al. 2020

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Background Dyspepsia is a common disorder in kidney transplant recipients, and the risk of post-transplant complications is increased in candidates with upper gastrointestinal disease. We evaluated gastrointestinal lesions of kidney transplant candidates on dialysis. Methods In this study, endoscopic and pathological findings in hemodialysis (HD) and peritoneal dialysis (PD) patients with gastrointestinal symptoms on the waiting list were compared. Results The most common non-ulcerous lesions in the endoscopic examination were gastritis (62.3%), erosive gastritis (38.7%), duodenal erosion or duodenitis (18.9%) and esophagitis (13.2%). The ulcerous lesion was present in only 3 patients. Gastroesophageal reflux disease, ulcerated lesion and non-ulcerated lesion rates were similar in both dialysis groups. Histopathological examination revealed Helicobacter pylori (HP) positivity in 28.3% of patients. HP positivity rate was significantly higher in PD patients than in HD patients (38.7% vs. 13.6%, p = 0.046). Chronic gastritis (75.5%) was the most common pathological finding. HP positivity rate was 37.5% in patients with chronic gastritis, but HP was negative in patients without chronic gastritis. In multivariate analysis, male gender, urea and albumin levels were associated with the presence of pathological chronic gastritis. The presence of gastritis, total cholesterol and ferritin levels were found significant for HP positivity. A total cholesterol > 243 mg/dL was significantly related to an increased risk of the presence of HP positivity. Conclusions Gastrointestinal lesions and HP infection are common in dialysis patients. Dialysis modality may affect the frequency of some lesions. It may be useful to have an endoscopic examination before entering the transplant waiting list for all candidates.

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Section: Discussioncontrasting

confidence: 37%

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

et al. 2020

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“… 20 Even so, an Egyptian study conducted with 90 chronic kidney disease patients on hemodialysis also found no significant differences between H. pylori -positive and -negative groups for any of the variables analyzed including hemoglobin, serum iron, ferritin and transferrin saturation. 21 In addition, an Egyptian study conducted in 60 children found that the soluble transferrin receptor in serum was significantly higher in the H. pylori -positive group compared to the H. pylori -negative group although no significant differences were noted in hematologic variables and iron parameters between the two groups. 22 This variability in studies could be due to differences in the geographical and ethnical distribution of patients, age, inclusion criteria, sample size, sampling procedures, methods of detecting anemia, and methods of detecting H. pylori infection.…”

Section: Discussionmentioning

confidence: 98%

Helicobacter pylori associated to unexplained or refractory iron deficiency anemia: an Egyptian single-center experience

Demerdash

Ibrahim

Hassan

et al. 2018

Hematology, Transfusion and Cell Therapy

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BackgroundRefractory or unexplained iron deficiency anemia accounts for about 15% of all cases. The endoscopic gastrointestinal workup sometimes fails to establish the cause of iron deficiency anemia and a considerable proportion of patients regardless of risk category fail to respond to oral iron supplementation. The aim of the present study was to assess the etiological role of Helicobacter pylori infection in adult Egyptian patients with unexplained or refractory iron deficiency anemia.MethodsA case controlled study was composed of 104 iron deficiency anemia cases and 70 age- and gender-matched healthy controls. Patients were diagnosed with iron deficiency anemia according to hemoglobin, mean corpuscular volume, serum ferritin, and transferrin saturation. Upper and lower endoscopies were performed and active H. pylori infection was investigated by testing for the H. pylori antigen in stool specimens. Hematological response to H. pylori treatment with triple therapy together with iron therapy (n = 32) or only iron therapy (n = 32) were assessed in patients with H. pylori infection.ResultsH. pylori infection was more prevalent in patients with unexplained or refractory iron deficiency anemia (61.5%). Of the different hematological parameters investigated, there was a significant correlation only between H. pylori infection and mean corpuscular volume (p-value 0.046). Moreover, there was a significant correlation between receiving triple therapy together with iron supplementation and improvements in the hematological parameters [hemoglobin (p-value < 0.001), mean corpuscular volume (p-value < 0.001), iron (p-value < 0.001) and serum ferritin (p-value < 0.001)] compared to receiving iron supplementation alone.ConclusionsFailing to test for H. pylori infection could lead to a failure to identify a treatable cause of anemia and could lead to additional and potentially unnecessary investigations. Furthermore, treatment of H. pylori infection together with iron supplementation gives a more rapid and satisfactory response.

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“…Cardenas VM et all., (2012), выдвинул предположение, что НР оказывает подавляющий эффект на дуоденальную СО, которые непосредственно ответственны за поглощение железа [39]. Но данным El-Said H. et al, (2017), не имеется существенные различия между показателями железодефицитной анемии у HР-положительными/НР-отрицательными пациентами: гемоглобин (8,96 ± 1,8 против 9,76 ± 1,4 g/dL), сывороточное железо (86 ± 17,5 против 87 ± 18,2 pg/dL), ферритин (284,8 ± 60,5 против 301,4 ± 50,1 ng/dL) или индекс насыщение трансферрина -TSAT (26,79 ± 18,42% против 29,83 ± 18,01% μg/dL) [40].…”

Section: связь между железодефицитной анемией и хеликобактериозомunclassified

The role of <i>Helicobacter pylori</i> in the development of iron defi ciency anaemia in children

Turdieva

Makhkamova

2023

jour

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A review article is devoted to the analysis of scientific and literary data published over the past 10 years, devoted to the problem of studying the role of Helicobacter pylori in the development of iron deficiency anaemia in children and adolescents. Comparative data of domestic and foreign scientists on the mechanism of exposure of Helicobacter pylori (НР) to the pathogenesis of resistant iron deficiency anaemia in children are given.It was determined that the development of iron deficiency anaemia in children with HP infection is influenced by many mechanisms, therefore, in the treatment of children with this pathology, the appointment of anti- HP bacterial therapy with ferrotherapy, taking into account age-related characteristics and needs, is justified.

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Does Helicobacter pylori infection play a role in iron deficiency anemia in hemodialysis patients?

Abstract: H. pylori infection has a nonsignificant effect on iron deficiency anemia in hemodialysis patients. We recommend that routine screening for H. pylori is not needed among dialysis patients with iron deficiency anemia. .

Cited by 8 publications

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Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

Helicobacter pylori associated to unexplained or refractory iron deficiency anemia: an Egyptian single-center experience

The role of <i>Helicobacter pylori</i> in the development of iron defi ciency anaemia in children

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Does Helicobacter pylori infection play a role in iron deficiency anemia in hemodialysis patients?

Abstract: H. pylori infection has a nonsignificant effect on iron deficiency anemia in hemodialysis patients. We recommend that routine screening for H. pylori is not needed among dialysis patients with iron deficiency anemia. .

Cited by 8 publications

References 0 publications

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

Helicobacter pylori associated to unexplained or refractory iron deficiency anemia: an Egyptian single-center experience

The role of <i>Helicobacter pylori</i> in the development of iron defi ciency anaemia in children

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Abstract: H. pylori infection has a nonsignificant effect on iron deficiency anemia in hemodialysis patients. We recommend that routine screening for H. pylori is not needed among dialysis patients with iron deficiency anemia. .