Does Helicobacter pylori-induced inflammation of gastric mucosa determine the severity of symptoms in functional dyspepsia?

Turkkan, Ebru; Uslan, Mustafa İhsan; Acartürk, Gürsel; Topak, Nevin; Kahraman, Ahmet; Dılek, Fatma Hüsniye; Akcan, Yusuf; Karaman, Ozcan; Çölbay, Mehmet; Yüksel, Şeref

doi:10.1007/s00535-008-2271-9

Cited by 25 publications

(24 citation statements)

References 36 publications

(31 reference statements)

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“…21 The result of Turkkan et al was supported from the result of this study. There was a significant association between There was a significant association between degree of neutrophil and MDA level.…”

supporting

confidence: 82%

Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan

Darmadi

Siregar

Dairi

2020

InaJGHE

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Background: The main pathogenesis of gastritis is inflammation which process can not be separated from the role of free radicals. Malondialdehyde (MDA) is a free radical biomarker and which increases in gastritis (p = 0.014; PR = 8.667;). There was a significant association between degree of neutrophil activity with high MDA level (p = 0.002; PR = 11.33;). There was a significant association between degree of atrophy with high level of MDA (p < 0.001; PR = 14;). There was a significant association between degree of intestinal metaplasia with high MDA level (p = 0.001; PR = 12.5;.Conclusion: There were significant associations between degree of lymphocyte infiltration, neutrophil activity, atrophy, and intestinal metaplasia with high level of MDA.

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supporting

confidence: 82%

Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan

Darmadi

Siregar

Dairi

2020

InaJGHE

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“…Turkkan et al19 reported that dyspepsia symptom scores were higher in patients with mild or moderate chronic inflammation of the corpus and antrum than in those with severe chronic inflammation, although the difference did not reach statistical significance. In studies conducted by Joshi et al20 and Pereira-Lima et al,21 no relationship was found between the severity of histological gastritis and the severity of the dyspeptic symptoms.…”

Section: Pathophysiological Link Between Helicobacter Pylori Infectiomentioning

confidence: 97%

What Is the Difference Between -Associated Dyspepsia and Functional Dyspepsia?

Suzuki

Matsuzaki²,

Hibi³

2011

J Neurogastroenterol Motil

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Advances in basic and clinical research have revealed that Helicobacter pylori (H. pylori) infection plays an important role in the development of gastroduodenal dysmotility and hypersensitivity, as also in dyspepsia symptoms. In addition, recent studies have proposed an inflammation-immunological model for the pathogenesis of functional dyspepsia. Since H. pylori is the major microbe that provokes a gastroduodenal inflammatory response, it should not be overlooked when considering the pathophysiology of dyspepsia symptoms. In fact, population-based studies have demonstrated that H. pylori is detected more frequently in dyspepsia patients. However, although many clinical studies tried to reveal the association of H. pylori infection with gastric motility dysfunction or hypersensitivity, the results have been conflicting. On the other hand, many etiological features were revealed for the development of H. pylori-associated dyspepsia, such as abnormal ghrelin or leptic secretion, altered expression of muscle-specific microRNAs, and duodenal inflammatory cell infiltration. In addition, therapeutic strategy for H. pylori-associated dyspepsia would be different from H. pylori-negative functional dyspepsia. This review focuses the issue of whether H. pylori-associated dyspepsia should be considered as a different disease entity from functional dyspepsia.

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“…2). In this context, it might be plausible that eradication therapy showed greater symptomatic benefits in Asian trials50 where more virulent strains causing severe mucosal inflammation are prevalent,28,29 although direct link between the mucosal inflammation and symptoms still remains to be controversial 51,52…”

Section: Proposal For Conceptual Consistencymentioning

confidence: 99%

Should We Still Subcategorize -Associated Dyspepsia as Functional Disease?

Sugano¹

2011

J Neurogastroenterol Motil

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Functional dyspepsia is a group of disorders featuring symptoms believed to be derived from the stomach and duodenum such as upper abdominal discomfort, pain, postprandial fullness and early satiety. A key diagnostic requisite is the absence of organic, metabolic, or systemic disorders to explain "dyspeptic symptoms." Therefore, when peptic ulcer diseases (including scars), erosive esophagitis and upper gastrointestinal malignancies are found at endoscopic examinations, the diagnosis of functional dyspepsia is excluded. One notable exception, however, is Helicobacter pylori infection. According to the Rome III definition, H. pylori infection is included in functional dyspepsia. This is an obvious deviation from the diagnostic principle of functional dyspepsia, since H. pylori infection is a definite cause of mucosal inflammation, which affects a number of important gastric physiologies such as acid secretion, gastric endocrine function and motility. The chronic persistent nature of infection also results in more dramatic mucosal changes such as atrophy or intestinal metaplasia, the presence of which in the esophagus (Barrett's esophagus) precludes the diagnosis of functional dyspepsia. Since careful endoscopic examination can diagnose reliably H. pylori infection not only in Japan but also in Western contries, it is now feasible and more logical to exclude patients with chronic gastritis caused by H. pylori infection as having dyspeptic symptoms. It is time to establish the Asian consensus to declare that H. pylori infection should be separated from functional dyspepsia.

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Does Helicobacter pylori-induced inflammation of gastric mucosa determine the severity of symptoms in functional dyspepsia?

Abstract: In conclusion, there may be an inverse relation between severity of symptoms and level of Helicobacter pylori induced gastric inflammation or oxidative stress in patients with functional dyspepsia.

Cited by 25 publications

References 36 publications

Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan

Association Between Degree of Gastritis and Malondialdehyde Level of Gastritis Patients at Adam Malik General Hospital Medan

What Is the Difference Between -Associated Dyspepsia and Functional Dyspepsia?

Should We Still Subcategorize -Associated Dyspepsia as Functional Disease?

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