Does Heart Rate Play a Role in Cardiovascular Outcome in Patients with Obstructive Sleep Apnea?

Sankari, Abdulghani

doi:10.1164/rccm.202012-4536le

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…This was confirmed in our study, where patients in the OSA group had a faster RHR and a higher proportion of HNRHR. Elevated RHR is a marker of increased sympathetic activity and a major cardiovascular disease risk factor 30) . Alterations in autonomic function may be a key mediator linking OSA and cardiovascular disease.…”

Section: Limitationsmentioning

confidence: 99%

The Long-Term Prognostic Role of Nighttime Resting Heart Rate in Obstructive Sleep Apnea in Patients with Acute Coronary Syndrome

Xin,

Ai,

Gong

et al. 2024

JAT

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Aim: A close relationship exists between resting heart rate (RHR) and obstructive sleep apnea (OSA). Still, the prognostic importance of nighttime RHR in patients with acute coronary syndrome (ACS) with or without OSA remains unclear. Methods: In this prospective cohort study, OSA was defined as an apnea–hypopnea index of ≥ 15 events/h, and the high nighttime RHR (HNRHR) was defined as a heart rate of ≥ 70 bpm. The primary endpoint was a major adverse cardiovascular and cerebrovascular event (MACCE), including cardiovascular death, myocardial infarction, stroke, ischemia-driven revascularization, or hospitalization for heart failure. Results: Among the 1875 enrolled patients, the mean patient age was 56.3±10.5 years, 978 (52.2%) had OSA, and 425 (22.7%) were in HNRHR. The proportion of patients with HNRHR is higher in the OSA population than in the non-OSA population (26.5% vs. 18.5%; P ＜0.001). During 2.9 (1.5, 3.5) years of follow-up, HNRHR was associated with an increased risk of MACCE in patients with OSA (adjusted HR: 1.56, 95% CI: 1.09–2.23, P =0.014), but not in patients without OSA (adjust HR: 1.13, 95% CI: 0.69–1.84, P =0.63). Conclusions: In patients with ACS, a nighttime RHR of ≥ 70 bpm was associated with a higher risk of MACCE in those with OSA but not in those without it. This identifies a potential high-risk subgroup where heart rate may interact with the prognosis of OSA. Further research is needed to determine causative relationships and confirm whether heart rate control impacts cardiovascular outcomes in patients with ACS-OSA.

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Section: Limitationsmentioning

confidence: 99%