Does gut brain axis has an impact on Parkinson’s disease (PD)?

Elangovan, Ajay; Dahiya, Bhawna; Kirola, Laxmi; Iyer, Mahalaxmi; Jeeth, Priyanka; Maharaj, Sakshi; Kumari, Nikki; Lakhanpal, Vikas; Michel, Tanja Maria; Rao, K.R.S. Sambasiva; Cho, Ssang-Goo; Yadav, Mukesh Kumar; Gopalakrishnan, Abilash Valsala; Kadhirvel, Saraboji; Kumar, Nachimuthu Senthil; Vellingiri, Balachandar

doi:10.1016/j.arr.2023.102171

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2024

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Cited by 3 publications

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“…In recent years, research on the gut microbiota has garnered widespread attention, encompassing various physiological processes, including immune regulation, nutritional metabolism, and the generation of bioactive molecules. The associations with a variety of diseases are gradually coming to light (3)(4)(5). Meanwhile, there exists a bidirectional signaling pathway between the gut and the brain, known as the gut-brain axis.…”

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confidence: 99%

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confidence: 99%

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The role of HLA-DR on plasmacytoid dendritic cells in mediating the effects of Butyrivibrio gut microbiota on Parkinson’s disease

Wang,

Xia,

Feng

et al. 2024

Neurol Sci

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Gut microbiota’s role in glioblastoma risk, with a focus on the mediating role of metabolites

Yan,

Li,

Luo

2024

Front. Neurol.

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This study employed Mendelian randomization (MR) analysis to systematically investigate the potential connections between gut microbiota and the risk of glioblastoma (GBM). We identified 12 microbial groups closely associated with the incidence risk of GBM. Subsequently, MR analysis was conducted on 1,091 blood metabolites and 309 metabolite ratios, revealing 19 metabolites that exert an impact on the occurrence of GBM. Hypothesizing that gut microbiota may influence the risk of glioblastoma multiforme by modulating these metabolites, we performed MR analyses, considering each microbial group as exposure and each metabolite as an outcome. Through these analyses, we constructed a regulatory network encompassing gut microbiota, metabolites, and GBM, providing a novel perspective for a deeper understanding of the role of the gut-brain axis in the pathogenesis of GBM. This research offers crucial insights into how gut microbiota may affect the risk of GBM by regulating specific metabolites. The identified regulatory network of the gut-brain axis may play a significant role in the formation and development of GBM, providing valuable information for future research and therapeutic interventions.

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Does gut brain axis has an impact on Parkinson’s disease (PD)?

Cited by 3 publications

References 194 publications

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The role of HLA-DR on plasmacytoid dendritic cells in mediating the effects of Butyrivibrio gut microbiota on Parkinson’s disease

Gut microbiota’s role in glioblastoma risk, with a focus on the mediating role of metabolites

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