Does green tea affect postprandial glucose, insulin and satiety in healthy subjects: a randomized controlled trial

Josic, Julija; Olsson, Anna; Wickeberg, Jennie; Lindstedt, Sandra; Hlebowicz, Joanna

doi:10.1186/1475-2891-9-63

Cited by 85 publications

(57 citation statements)

References 29 publications

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“…The most recent trial was a crossover study with 14 healthy volunteers [56]. The subjects were randomized into treatment or control group.…”

Section: Green Teamentioning

confidence: 99%

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Deng¹

2012

FNA

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Hyperglycemia is a pathological condition associated with prediabetes and diabetes. The incidence of prediabetes and diabetes is increasing and imposes great burden on healthcare worldwide. Patients with prediabetes and diabetes have significantly increased risk for cardiovascular diseases and other complications. Currently, management of hyperglycemia includes pharmacological interventions, physical exercise, and change of life style and diet. Food supplements have increasingly become attractive alternatives to prevent or treat hyperglycemia, especially for subjects with mild hyperglycemia. This review summarized current patents and patent applications with relevant literature on five commonly used food supplements with claims of hypoglycemic effects, including emblica officinalis (gooseberry), fenugreek, green tea, momordica charantia (bitter melon) and cinnamon. The data from human clinical studies did not support a recommendation for all five supplements to manage hyperglycemia. Fenugreek and composite supplements containing emblica officinalis showed the most consistency in lowering fasting blood sugar (FBS) or glycated hemoglobin (HbA1c) levels in diabetic patients. The hypoglycemic effects of cinnamon and momordica charantia were demonstrated in most of the trials with some exceptions. However, green tea exhibited limited benefits in reducing FBS or HbA1c levels and should not be recommended for managing hyperglycemia. Certain limitations are noticed in a considerable number of clinical studies including small sample size, poor experimental design and considerable variations in participant population, preparation format, daily dose, and treatment duration. Future studies with more defined participants, standardized preparation and dose, and improved trial design and size are warranted.

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“…The most recent trial was a crossover study with 14 healthy volunteers [56]. The subjects were randomized into treatment or control group.…”

Section: Green Teamentioning

confidence: 99%

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Deng¹

2012

FNA

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“…A study which assessed the associations between habitual consumption of all flavonoid subclasses and weight gain among 124,086 American men and women over a period of 24 years showed higher intake of foods rich in flavonols, flavan-3-ols, anthocyanins, and flavonoid polymers may contribute to weight maintenance in adulthood after adjustment for changes in other lifestyle factors such as diet, smoking status, and physical activity [9]. Several other studies on human and rodents provide evidence that flavonoids can cause suppression of appetite [10][11][12], increase glucose uptake in muscle [13], decrease fat absorption [14], and inhibit adipogenesis [15,16].…”

Section: Introductionmentioning

confidence: 99%

Differential effects of dietary flavonoids on adipogenesis

et al. 2018

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Propose Obesity is a fast growing epidemic worldwide. During obesity, the increase in adipose tissue mass arise from two different mechanisms, namely, hyperplasia and hypertrophy. Hyperplasia which is the increase in adipocyte number is characteristic of severe obese patients. Recently, there has been much interest in targeting adipogenesis as therapeutic strategy against obesity. Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development. Methods Presently, we provide a review of key studies evaluating the effects of dietary flavonoids in different stages of adipocyte development with a particular emphasis on the investigations that explore the underlying mechanisms of action of these compounds in human or animal cell lines as well as animal models. Results Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development. Although most of the studies reveal anti-adipogenic effect of flavonoids, some flavonoids demonstrated proadipogenic effect in mesenchymal stem cells or preadipocytes. Conclusion The anti-adipogenic effect of flavonoids is mainly via their effect on regulation of several pathways such as induction of apoptosis, suppression of key adipogenic transcription factors, activation of AMPK and Wnt pathways, inhibition of clonal expansion, and cell-cycle arrest.

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“…The study design was based on previous reports [25,26]. Subjects were asked to consume the antioxidant-rich food extract with either a glucose or carbohydrate (white bread) load; their effects on postprandial glucose levels were measured.…”

Section: Methodsmentioning

confidence: 99%

“…The available carbohydrate content of the glucose was determined by AsureQuality NZ Ltd using gas chromatography as described previously [27]. Study 2 was based upon the protocol outlined by Josic et al (2010) [25] All 10 participants performed both Study 1 and Study 2. Each participant had six test sessions per study, which included a control test session and five different antioxidant food extract test sessions.…”

Section: Methodsmentioning

confidence: 99%

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Chepulis¹,

Al-Aubaidy²,

Page³

2016

FFHD

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Background: Obesity and diabetes are highly prevalent in Western countries. Both of these conditions can be associated with impaired glucose control and hyperglycemia. Studies have identified that antioxidants have the ability to regulate blood glucose levels. However, the effects of specific high-antioxidant food extracts on blood glucose levels have not been well characterized. Thus, this study aimed to measure the effects of selected antioxidant food extracts on postprandial glucose responses in healthy individuals. Methods:Ten healthy individuals were recruited into a randomized, single-blinded study. Participants consumed five different high-antioxidant food extracts (one per session, each >48 hours apart) that were matched for total antioxidant content 10 mins prior to ingestion of 50 g of available carbohydrate from either a glucose load or white bread (with ham) after an overnight fast. Blood glucose levels were measured using capillary sampling every 15 mins for two hours and the incremental area under the glucose curve (IAUC) was also measured. The IAUC values for the test foods were compared to the glucose-only and bread-only controls.Results: Amla berry-, grape seed-rooibos tea-and green tea-extracts as well as propolis tincture were all strong glycemic modulators, significantly decreasing the IAUC by 25-40% compared to the glucose-only or white bread controls (all p < 0.05). Conclusion:Antioxidants are able to modulate postprandial glucose responses in healthy subjects. These results suggest that further research is warranted to determine whether these antioxidant-rich foods are beneficial to people with prediabetes or type 2 diabetes mellitus.

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Does green tea affect postprandial glucose, insulin and satiety in healthy subjects: a randomized controlled trial

Cited by 85 publications

References 29 publications

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Differential effects of dietary flavonoids on adipogenesis

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

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