Does gene expression analysis inform us in rheumatoid arthritis?

Abstract

Transcription profiling has become a standard technology in research. It is mainly applied in the search for biomarkers to improve diagnostic and prognostic classification, to quantify disease activity and to predict or indicate response to therapy. This review will focus on rheumatoid arthritis and discuss considerations for sample selection, prerequisites for functional interpretation of data and the current status of information deduced in the field of biomarkers for the various clinical questions. In the next few years, prediction of response to treatment is the most important aim of biomarker research. With the growing number of new biological agents, there is increasing pressure to identify molecular parameters that will not only guide the therapeutic decision but also help to define the most important targets for which new biological agents should be tested in clinical studies.

Synovial tissue research: a state-of-the-art review

“…Different subtypes of RA patient synovia have also been characterised by gene expression analysis. 112,113 Geneexpression variance among RA patients has been described impacting several pathways involved in cell proliferation, cell survival, angiogenesis and regulation of inflammation. 114 …”

Biomarkers

“…According to Häupl et al [5], predicting response to treatment will become the most important aim of biomarker research in medicine. With the growing number of new biological agents, there is increasing pressure to identify molecular parameters that not only guide the therapeutic decision but also help to define the most important targets for which new biological agents should be tested in clinical studies.…”

Biopsieindikationen

“…Die immunhistochemische Darstellung von CD3-oder CD20-positiven Lymphozyten kann die Detektion von Lymphozyten erleichtern und u. U. Hinweise auf eine atypische monoklonale Lymphozytenproliferation liefern (Differenzialdiagnose Lymphom), ist aber kein notwendiger Bestandteil [1]. Beachtet werden sollte, dass das Rauchen einen Einfluss auf das entzündliche Infiltrat in den Speicheldrüsen ausübt [9]. FerDurch Addition der entzündlichen Veränderungen für die 3 unterschiedlichen Kompartimente der Synovialitis ergibt sich ein ScoreWert zwischen 0 und 9 Die Diagnose "Low grade-Synovialitis" ist mit gering bzw.…”