Does gender affect neonatal hyperbilirubinemia in low-birth-weight infants?

Tioseco, Jennifer A.; Aly, Hany; Milner, Josh; Patel, Kantilal M.; El-Mohandes, Ayman

doi:10.1097/01.pcc.0000154961.37833.79

Cited by 24 publications

(17 citation statements)

References 15 publications

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“…This study also proved that there was significant high TSB level among males in the prophylactic group in all days except fifth day and significant high TSB level in males in the therapeutic group in all days and this results were agree with study done by TIOSECO JA et al [ 15 ].…”

Section: Discussionsupporting

confidence: 92%

Role of Prophylactic Phototherapy in the Management of very Low Birth weight Newborns with Hyperbilirubinemia in Comparison to Therapeutic Phototherapy with their Gender

Khalil¹,

Rafeeq²,

Noaman³

2019

DJM

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Background: Bilirubin associated brain damage is great in the preterm and low birth weight newborns. Phototherapy is able to control the level of bilirubin in low birth weight newborns. Objective:To show the role of prophylactic phototherapy in the management of very low birth weight newborns weighting(1-1.5)kg with hyperbilirubinemia in comparison to therapeutic method. Patients and Methods: Across sectional study; Very low birth weight newborns weighting (1-1.5)kg were included in the study and admitted to neonatal care unit because of their very low birth weight and family consent had taken about admission and prophylactic phototherapy from some families so the total number of newborns was forty, twenty newborns were received phototherapy within nine hours of birth and lasted for seven days while twenty newborns were received phototherapy when indicated according to birth weight and continued to seventh day after birth , analysis was made for mean daily bilirubin level , duration of phototherapy , peak bilirubin level in the prophylactic and therapeutic groups and blood exchange need. Results: The highest daily mean level of total serum bilirubin(TSB) of prophylactic group was 6.5±0.4 mg/dl, which happened on the fifth day. In the therapeutic group, it was 8.7±0.5 mg/dl on the fifth day after birth. There was significant difference in the TSB values of prophylactic group which was less than that of therapeutic group from second to sixth days(p<0.0001). The median duration of phototherapy in the treatment group was shorter than that of the prophylactic group. Conclusion: Prophylactic phototherapy in very low birth weight preterm infants weighting (1-1.5) kg can significantly decrease jaundice after birth compared with the therapeutic group, also this study indicate that there is significant high TSB level among males in both groups in comparison to females.

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Section: Discussionsupporting

confidence: 92%

Role of Prophylactic Phototherapy in the Management of very Low Birth weight Newborns with Hyperbilirubinemia in Comparison to Therapeutic Phototherapy with their Gender

Khalil¹,

Rafeeq²,

Noaman³

2019

DJM

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“…We have documented a significantly higher prevalence of hyperbilirubinemia in male newborns. This observation is consistent with the results of previous research, however, the mechanism of this phenomenon is not clear (Tioseco et al, 2005). We did not reveal a statistically significant association between presence of the UGT1A1*60 polymorphism and the prevalence of hyperbilirubinemia in our group.…”

Section: Discussionsupporting

confidence: 92%

“…We have also analyzed the effect of birth weight on the prevalence of hyperbilirubinemia but did not find a significant association between these two parameters. According to some authors, low birth weight is a risk factor of jaundice (Scafford et al, 2013;Tioseco et al, 2005;Okwundu et al, 2013;Yang et al, 2013). Indeed, the immaturity of enzymatic systems in preterm newborns constitutes a potent factor modulating the severity of jaundice, and most preterm babies are delivered with low birth weight (Huang et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Association between uridin diphosphate glucuronosylotranserase 1A1 (UGT1A1) gene polymorphism and neonatal hyperbilirubinemia

et al. 2017

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“…The incidence of apnea was higher in infants with hyporeflexia and opistotunos at admission and also hypernatremia was higher among infants with hyporeflexia. 8,11 The mean total serum bilirubin level in our cases was 29.39±6.13mg/ dL. 9 Weisz B et al reported 203 exchange transfusions on 143 infants with hyperbilirubinemia during 1983-1992.…”

Section: Resultsmentioning

confidence: 58%

Adverse events associated with neonatal exchange transfusion for hyperbilirubinemia

et al. 2009

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To estimate the incidence of blood exchange and determine causes and complication of blood exchange and identify strategies for risk reduction of Kernicterus in newborn with jaundice. From March 2004 to March 2006 in neonatal Department in children hospital, medical center Tehran, Iran, 346 neonates were admitted as neonatal jaundice without sign and symptoms of infections. We identified causes and complications of exchange. Of 346 infants with jaundice who received phototherapy. 50, 14.45 percent cases underwent exchange transfusion with mean age 9.38 + 5.75 days. The mean total Serum bilirubin level was 29.39 + 6.13 mg/dl. ABO incompatibility was the most common cause for hyperbilirubinemia. The incidence of apnea was 12% there was no direct death from exchange transfusion. To make payment women aware to observe jaundice regularly after birth of their child and short breast feeding to control dehydration.

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Does gender affect neonatal hyperbilirubinemia in low-birth-weight infants?

Cited by 24 publications

References 15 publications

Role of Prophylactic Phototherapy in the Management of very Low Birth weight Newborns with Hyperbilirubinemia in Comparison to Therapeutic Phototherapy with their Gender

Role of Prophylactic Phototherapy in the Management of very Low Birth weight Newborns with Hyperbilirubinemia in Comparison to Therapeutic Phototherapy with their Gender

Association between uridin diphosphate glucuronosylotranserase 1A1 (UGT1A1) gene polymorphism and neonatal hyperbilirubinemia

Adverse events associated with neonatal exchange transfusion for hyperbilirubinemia

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