Does food ingestion during hemodialysis lead to change in hepatic oxygenation?

Imai, Sojiro; K, Ito; Ookawara, Susumu; Kiryu, Satoshi; Iguchi, Miho; Sanayama, Hidenori; Kakei, Masafumi; Tabei, Kaoru; Morishita, Yoshiyuki

doi:10.1016/j.nefroe.2022.11.009

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Particularly, predicting the development of IDH using rSO 2 changes would be an interesting research topic in the future. Third, the rSO 2 values may have been influenced by various dialysis conditions, such as the dialysis setting and various physiological factors [9][10][11][13][14][15]. Fourth, the sample size in this study was small, and organ rSO 2 was measured only once per patient.…”

Section: Discussionmentioning

confidence: 98%

“…We have previously focused on the hepatic and cerebral rSO 2 in patients undergoing HD and reported the clinical importance of their changes in different clinical situations related to HD treatment [8][9][10][11]. Interestingly, hepatic and cerebral rSO 2 appear to change asynchronously under various HD conditions (e.g., blood transfusion during HD, treatment of congestive heart failure with HD, and feeding during HD) [13][14][15]. For example, during HD with ultrafiltration for congestive heart failure, the hepatic rSO 2 appears to recover faster than its cerebral counterpart [13].…”

Section: Introductionmentioning

confidence: 99%

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Differences between Hepatic and Cerebral Regional Tissue Oxygen Saturation at the Onset of Intradialytic Hypotension

Kaneko

Ookawara

et al. 2023

JCM

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Background: Intradialytic hypotension (IDH) is a critical pathological condition associated with all-cause mortality in patients undergoing hemodialysis (HD). However, few studies have investigated IDH-related changes in hepatic and cerebral regional tissue oxygen saturation (rSO2). This study investigated IDH-induced changes in hepatic and cerebral rSO2. Methods: Hepatic and cerebral rSO2 during HD were measured using an INVOS 5100C oxygen saturation monitor, and their percentage (%) changes during the development of IDH were analyzed. Ninety-one patients undergoing HD were investigated, including twenty with IDH. Results: In patients with IDH, % changes in hepatic and cerebral rSO2 decreased at the onset of IDH. Additionally, the % change in hepatic rSO2 was significantly larger than that in cerebral rSO2 (p < 0.001). In patients without IDH, no significant differences were found between the % changes in hepatic and cerebral rSO2 at the time of the lowest systolic blood pressure during HD. Multivariable linear regression analysis showed that the difference between the % changes in cerebral and hepatic rSO2 was significantly associated with the development of IDH (p < 0.001) and the ultrafiltration rate (p = 0.010). Conclusions: Hepatic and cerebral rSO2 significantly decreased during the development of IDH, and hepatic rSO2 was more significantly decreased than cerebral rSO2 at the onset of IDH.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Differences between Hepatic and Cerebral Regional Tissue Oxygen Saturation at the Onset of Intradialytic Hypotension

Kaneko

Ookawara

et al. 2023

JCM

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“…Fourth, hepatic rSO 2 has shown a change in the critical balance between arterial oxygen delivery and tissue oxygen consumption; 5,6 therefore, the decrease in arterial hepatic oxygenation during HD may theoretically be associated with increased oxygen consumption by hepatic tissues. Fifth, intradialytic feeding induces the reduction of relative changes in blood volume in systemic circulation, 27 which frequently leads to the onset of IDH, and the deterioration of hepatic oxygenation 28 during HD.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting intradialytic hepatic oxygenation: Associations between ultrafiltration rate and changes in systemic blood pressure

Ookawara

Ueda

et al. 2023

Int J Artif Organs

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Introduction: Hepato-splanchnic circulation influences the oxygenation of abdominal organs and is important in preventing a reduction in intradialytic blood volume. However, the association between changes in intradialytic hepato-splanchnic circulation and clinical factors remain unknown. Methods: We enrolled 91 hemodialysis (HD) patients (20 with intradialytic hypotension (IDH) and 71 without IDH). During HD, hepatic regional oxygen saturation (rSO2), a marker of hepatic oxygenation reflecting hepato-splanchnic circulation and oxygenation, was monitored. Changes in hepatic rSO2 at the lowest systolic blood pressure (BP) during HD were analyzed to identify associations with clinical factors. Results: Hepatic rSO2 levels were 55.8 ± 15.3% before HD and 53.8 ± 14.9% at the lowest systolic BP; therefore, % changes in hepatic rSO2 were −2.7 ± 11.3%. These values were significantly lower in patients with IDH than in those without IDH (−13.8 ± 9.3% vs 0.4 ± 9.8%, p < 0.001). Multivariable regression analysis showed that % changes in hepatic rSO2 were independently associated with % changes in systolic BP (standardized coefficient: 0.416) and ultrafiltration rate (−0.206). Furthermore, % changes in mean BP (0.304) were identified as affecting % changes in hepatic rSO2 instead of those in systolic BP. Conclusions: Changes in intradialytic hepatic oxygenation is associated with ultrafiltration rate and changes in systemic BP. Further studies are required to clarify the directionality of the association between changes in hepatic oxygenation and changes in systemic BP during HD.

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Does food ingestion during hemodialysis lead to change in hepatic oxygenation?

Cited by 2 publications

References 6 publications

Differences between Hepatic and Cerebral Regional Tissue Oxygen Saturation at the Onset of Intradialytic Hypotension

Differences between Hepatic and Cerebral Regional Tissue Oxygen Saturation at the Onset of Intradialytic Hypotension

Factors affecting intradialytic hepatic oxygenation: Associations between ultrafiltration rate and changes in systemic blood pressure

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