Does food ingestion during hemodialysis lead to change in hepatic oxygenation?

Imai, Sojiro; K, Ito; Ookawara, Susumu; Kiryu, Satoshi; Iguchi, Miho; Sanayama, Hidenori; Kakei, Masafumi; Tabei, Kaoru; Morishita, Yoshiyuki

doi:10.1016/j.nefro.2021.04.023

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fourth, hepatic rSO 2 has shown a change in the critical balance between arterial oxygen delivery and tissue oxygen consumption; 5,6 therefore, the decrease in arterial hepatic oxygenation during HD may theoretically be associated with increased oxygen consumption by hepatic tissues. Fifth, intradialytic feeding induces the reduction of relative changes in blood volume in systemic circulation, 27 which frequently leads to the onset of IDH, and the deterioration of hepatic oxygenation 28 during HD. Patients with intradialytic feeding were excluded from this study.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting intradialytic hepatic oxygenation: Associations between ultrafiltration rate and changes in systemic blood pressure

Ookawara

Ueda

et al. 2023

Int J Artif Organs

View full text Add to dashboard Cite

Introduction: Hepato-splanchnic circulation influences the oxygenation of abdominal organs and is important in preventing a reduction in intradialytic blood volume. However, the association between changes in intradialytic hepato-splanchnic circulation and clinical factors remain unknown. Methods: We enrolled 91 hemodialysis (HD) patients (20 with intradialytic hypotension (IDH) and 71 without IDH). During HD, hepatic regional oxygen saturation (rSO2), a marker of hepatic oxygenation reflecting hepato-splanchnic circulation and oxygenation, was monitored. Changes in hepatic rSO2 at the lowest systolic blood pressure (BP) during HD were analyzed to identify associations with clinical factors. Results: Hepatic rSO2 levels were 55.8 ± 15.3% before HD and 53.8 ± 14.9% at the lowest systolic BP; therefore, % changes in hepatic rSO2 were −2.7 ± 11.3%. These values were significantly lower in patients with IDH than in those without IDH (−13.8 ± 9.3% vs 0.4 ± 9.8%, p < 0.001). Multivariable regression analysis showed that % changes in hepatic rSO2 were independently associated with % changes in systolic BP (standardized coefficient: 0.416) and ultrafiltration rate (−0.206). Furthermore, % changes in mean BP (0.304) were identified as affecting % changes in hepatic rSO2 instead of those in systolic BP. Conclusions: Changes in intradialytic hepatic oxygenation is associated with ultrafiltration rate and changes in systemic BP. Further studies are required to clarify the directionality of the association between changes in hepatic oxygenation and changes in systemic BP during HD.

show abstract

Section: Discussionmentioning

confidence: 99%