2015
DOI: 10.1016/j.gene.2015.08.069
|View full text |Cite
|
Sign up to set email alerts
|

Does familial breast cancer and thymoma suggest a cancer syndrome? A family perspective

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
7
0

Year Published

2016
2016
2019
2019

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(7 citation statements)
references
References 20 publications
0
7
0
Order By: Relevance
“…In this study, the occurrence of these malignancies does not correlate with biologic behavior of DNA ploidy of thymoma (14). A recent study, based on a family with five ovarian/breast cancer patients and two thymoma patients, did not support the notion, that the concurrent appearance of breast cancer and thymoma, represent a familial cancer syndrome, caused by the same genetic disorder (15).…”
Section: Thymoma and Breast Cancermentioning
confidence: 92%
“…In this study, the occurrence of these malignancies does not correlate with biologic behavior of DNA ploidy of thymoma (14). A recent study, based on a family with five ovarian/breast cancer patients and two thymoma patients, did not support the notion, that the concurrent appearance of breast cancer and thymoma, represent a familial cancer syndrome, caused by the same genetic disorder (15).…”
Section: Thymoma and Breast Cancermentioning
confidence: 92%
“…It seems that the familial occurrence is poorly recorded and thus its prevalence is underestimated [1]. The genetic factors that may contribute to this familial clustering are not well known [14,17]. We report two families whose members presented different forms of thymic pathology.…”
Section: Introductionmentioning
confidence: 90%
“…The post mortem examination revealed a thymoma. The prevalence of familial thymoma is estimated between 1 and 4 per million and its cause is also unknown [13][14][15][16][17]. Familial thymomas can be associated with other malignancies and autoimmune diseases [14,17].…”
Section: Familymentioning
confidence: 99%
See 1 more Smart Citation
“…A similar report described a family with frequent thymomas, potentially attributed to a germline translocation of the BRCA2 ‐associated DNA repair protein RAD51B . Another family was reported to have high rates of BRCA‐linked breast/ovarian cancers and thymomas, although there was insufficient evidence to suggest a familial cancer syndrome caused by a single unifying mutation . Of note, one series of 72 patients with thymoma or thymic carcinoma identified 1 patient with an ataxia‐telangiectasia mutated ( ATM ) gene mutation, which can affect DNA repair mechanisms similar to BRCA mutations .…”
Section: Functional and Clinical Significance Of The Specific Mutatiomentioning
confidence: 99%